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Postdoctoral Position Computational Biophysics Jobs in Tennessee

St. Jude Children's Research Hospital

Postdoctoral Research Associate - Quantitative Microscopy and Live-Cell Chromatin Imaging Location Memphis, TN Category Postdoc Department Shift Weekday Day Position Type Full Time Scheduled Weekly

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Postdoctoral Position Computational Biophysics information

What is a postdoctoral position in computational biophysics?

A Postdoctoral Position in Computational Biophysics is a temporary research role for individuals who have recently obtained a PhD in a related field. In this position, researchers use computational tools and theoretical models to study biological systems at the molecular or cellular level. The work often involves simulating biomolecules, analyzing large datasets, and developing new computational methods to understand biological processes. These positions are typically held at universities or research institutes and are designed to provide further training and experience before pursuing a permanent academic or industry role.

What are the key skills and qualifications needed to thrive as a postdoctoral researcher in computational biophysics?

To thrive as a Postdoctoral Researcher in Computational Biophysics, a strong background in physics, chemistry, or biology along with a PhD and advanced computational modeling skills is essential. Expertise in programming languages (such as Python, C++, or MATLAB), molecular dynamics software (like GROMACS or AMBER), and high-performance computing platforms is typically required. Excellent problem-solving abilities, collaboration, and effective scientific communication are standout soft skills in this field. These skills enable researchers to design, execute, and communicate complex simulations that advance understanding of biological systems and drive scientific discovery.

What are some typical challenges faced by postdoctoral researchers in computational biophysics, and how can they be addressed?

Postdoctoral researchers in computational biophysics often encounter challenges such as integrating complex biological data with advanced computational models, staying current with rapidly evolving software tools, and balancing independent research with collaborative projects. These challenges can be addressed by proactively seeking interdisciplinary collaborations, attending workshops to enhance technical skills, and regularly consulting with mentors and peers. Establishing efficient workflows and participating in lab meetings also helps in managing time and staying aligned with research goals.

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For Postdoctoral Position Computational Biophysics jobs in Tennessee, the most frequently searched job titles are:

What job categories do people searching Postdoctoral Position Computational Biophysics jobs in Tennessee look for?

The top searched job categories for Postdoctoral Position Computational Biophysics jobs in Tennessee are:

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Cities in Tennessee with the most Postdoctoral Position Computational Biophysics job openings:

Postdoctoral Position Computational Biophysics jobs near you
Infographic showing various Postdoctoral Position Computational Biophysics job openings in Tennessee as of August 2026, with employment types broken down into 92% Full Time, 4% Part Time, and 4% Contract. Highlights an 91% In-person, and 9% Remote job distribution.

Postdoctoral Research Associate - Chemical Biology & Therapuetics

Memphis, TN • On-site

St. Jude Children's Research Hospital
Health Care and Social Assistance • 1 - 5K employees
Learn more about St. Jude Children's Research Hospitalexternal

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Re-posted 17 days ago

St. Jude Children's Research Hospital rating

8.8

Company rating: 8.8 out of 10

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Job description

Postdoctoral Research Associate - Chemical Biology & Therapuetics

Location: Memphis, TN

Job Description

A postdoc position is available in the lab of Taosheng Chen. The Chen Lab (https://www.stjude.org/research/labs/chen-lab-taosheng.html) is seeking a Postdoctoral Research Associate to work in a multidisciplinary team to study the regulation of PXR and CAR, or CYP3A4 and CYP3A5, by characterizing novel chemical probes (small molecule inhibitors or degraders) in biochemical/biophysical, cellular, and animal models.

Drug toxicity and resistance are leading causes of therapeutic failures. The Chen Lab studies the chemical regulation of nuclear xenobiotic receptors and the mechanism of selective modulation of highly homologous drug‑metabolizing enzymes. Our approach is hypothesis‑driven and technology‑enabled, focusing on developing chemical probes, investigating biological mechanisms, and evaluating in‑vivo efficacy. We use the promiscuous pregnane X receptor (PXR) and constitutive androstane receptor (CAR) as models to understand nuclear receptor‑regulated transcription networks, enzyme‑drug interactions, and design therapeutic approaches to overcome drug resistance and toxicity.

Postdoctoral fellows will collaborate across biologists, medicinal chemists, and structural biologists to characterize novel probes, organize and prepare manuscripts, and develop grant proposals. Fellows are trained in manuscript and grant writing and are encouraged to prepare and submit grant proposals.

St. Jude is an Equal Opportunity Employer.

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