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Portfolio Director Clinical Jobs (NOW HIRING)

$59K - $80K/yr

Overview The Senior Director, Clinical Science is a strategic scientific leader responsible for ... Responsibilities Clinical Development and Portfolio Leadership * Provide strategic leadership for ...

As the Director, Clinical Operations, you will lead the clinical operations function responsible ... Own the clinical operations strategy across WHOOP's portfolio of regulated and unregulated health ...

$59K - $80K/yr

Our comprehensive portfolio of over 400 products is fully integrated and built to serve our ... The Director, Surgical Clinical Development will serve as a strategic and scientific leader for ...

Senior Director, Clinical Development

Malvern, PA · On-site

$78K - $107K/yr

Job Title Senior Director, Clinical Development Requisition JR000015848 Senior Director, Clinical ... Helps to identify additional opportunities within the broad R&D portfolio; propose indications and ...

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Portfolio Director Clinical information

See salary details

$51.5K

$100.1K

$167K

How much do portfolio director clinical jobs pay per year?

As of Sep 15, 2026, the average yearly pay for portfolio director clinical in the United States is $100,124.00, according to ZipRecruiter salary data. Most workers in this role earn between $80,000.00 and $109,000.00 per year, depending on experience, location, and employer.

What does a portfolio director clinical do?

A Portfolio Director Clinical is responsible for overseeing and managing a group of clinical trials or studies within a pharmaceutical, biotechnology, or healthcare organization. They ensure that all projects within their portfolio are aligned with strategic objectives, meet regulatory requirements, and adhere to timelines and budgets. This role involves collaborating with cross-functional teams, providing leadership, and making key decisions to optimize trial execution and delivery. Additionally, they may be involved in resource allocation, risk management, and communication with stakeholders.

What are the key skills and qualifications needed to thrive as a portfolio director clinical?

To thrive as a Portfolio Director Clinical, you need a robust background in clinical research, project management, and a relevant advanced degree (such as an RN, PharmD, MD, or PhD). Familiarity with clinical trial management systems (CTMS), regulatory compliance tools, and certifications like PMP or equivalent are typically advantageous. Exceptional leadership, strategic thinking, and strong communication skills help drive cross-functional teams and stakeholder engagement. These skills ensure efficient delivery of clinical programs, regulatory adherence, and successful portfolio outcomes in complex healthcare environments.

What are some common challenges faced by a portfolio director clinical, and how can applicants prepare to address them?

Portfolio Directors in Clinical roles often navigate complex project portfolios, balancing competing timelines, regulatory requirements, and stakeholder expectations across multiple studies. One common challenge is ensuring effective cross-functional collaboration among clinical operations, regulatory affairs, and data management teams. Applicants can prepare by cultivating strong leadership, project management, and communication skills, as well as gaining experience in risk assessment and mitigation strategies. Demonstrating prior success in managing multi-study portfolios and fostering team alignment will help you stand out in this role.

What is the difference between Portfolio Director Clinical vs Clinical Program Manager?

AspectPortfolio Director ClinicalClinical Program Manager
ResponsibilitiesOversees multiple clinical projects or programs, strategic planning, stakeholder managementManages individual clinical programs, ensures project delivery, team coordination
Required CredentialsTypically requires advanced degrees (e.g., MD, PhD, or equivalent), clinical experience, leadership skillsUsually requires a relevant clinical or life sciences degree, project management experience
Work EnvironmentCorporate or pharmaceutical settings, strategic planning focusResearch institutions, healthcare organizations, project execution focus

The main difference is that a Portfolio Director Clinical oversees multiple clinical projects and sets strategic direction, while a Clinical Program Manager focuses on managing specific clinical programs and ensuring their successful execution. The Portfolio Director has broader responsibilities and higher-level oversight.

What are popular job titles related to Portfolio Director Clinical jobs?

For Portfolio Director Clinical jobs, the most frequently searched job titles are:

Infographic showing various Portfolio Director Clinical job openings in the United States as of June 2026, with employment types broken down into 1% As Needed, 89% Full Time, 9% Part Time, and 1% Contract. Highlights an 95% Physical, 1% Hybrid, and 4% Remote job distribution, with an average salary of $100,124 per year, or $48.1 per hour.

Portfolio Director - Immunology (US/EU)

South San Francisco, CA

Novotech
Guided Missile and Space Vehicle Manufacturing • 11 - 50 employees

$200K - $275K/yr

Full-time

Posted 21 days ago


Key responsibilities

  • Lead and oversee the execution of multiple clinical development projects within the Portfolio, ensuring alignment with client strategic goals and regulatory requirements.

  • Manage and coach Project Directors and Project Managers, providing guidance, support, and development opportunities.

  • Monitor project performance, delivery timelines, financial health, and client satisfaction to ensure successful project outcomes.


Job description

Responsibilities:

Portfolio Growth & Management

Take a leading role in growing the Portfolio book of business through working closely with the Medical & Scientific Strategist (MSS) and Business Development Team to develop successful operational strategy and delivery plans for project Proposals; participate in Bid Defense Meetings and lead operational follow-up activities.

Work with MSS to develop and maintain "Play Books", White Papers, Marketing materials, Scientific Advisor Panels, service offerings, etc to ensure the continued growth of the Portfolio.

Lead and oversee the execution of multiple clinical development projects within the Portfolio, ensuring alignment with client strategic goals and regulatory requirements.

Develop and maintain strong relationships with clients, acting as the primary point of contact for client management in relation to project-related matters.

Monitor key performance indicators (KPIs) to measure project performance, delivery timelines, financial health, and client satisfaction.

Ensure that all projects comply with ICH-GCP guidelines and applicable regulatory requirements.

Leadership and People Management

Manage and coach Project Directors and Project Managers, providing guidance, support, and development opportunities both within the Portfolio and the wider Novotech business.

Foster a high-performing culture across the Portfolio by encouraging collaboration, accountability, and continuous improvement.

Ensure optimal resource allocation and utilization across projects in alignment with business needs.

Strategic Planning & Execution

Collaborate with the Head PM [Immunology & Infectious Disease] Therapeutic Area to contribute to the strategic plans and direction of the TA.

Participate in long-term planning for the TA, driving initiatives to optimize processes, improve efficiency, and achieve growth targets.

Work closely with cross-functional leadership to ensure Project Team and project success.

Client Engagement & Satisfaction

Serve as the primary point of contact for clients, managing relationships at the Portfolio level to ensure client satisfaction and loyalty.

Lead Portfolio-level client meetings and provide updates on project progress, risks, and mitigation strategies. 

Identify and address client considerations to maintain and develop the health of the relationship in a proactive manner.

Risk Management

Identify, assess, and mitigate risks at the portfolio level, implementing corrective and preventive actions as needed.

Ensure that all projects within the portfolio adhere to internal and external risk management policies and procedures.

Financial Oversight

Oversee the financial performance of the Portfolio, managing budgets, forecasting, and ensuring profitability.

Collaborate with Finance and senior management to ensure financial health and accurate reporting of the Portfolio's financial performance.

Ensure appropriate resource allocation to meet the financial and operational needs of the Portfolio.

Minimum Qualifications & Experience:

Bachelor's or advanced degree in Life Sciences, Clinical Research, or a related field.

10+ years of experience in clinical research, with 5+ years in project management or portfolio management roles.

Strong knowledge of clinical trials, drug development, and regulatory requirements (e.g., ICH-GCP).

Proven experience in leading large, complex projects and managing cross-functional teams in a global environment.

Highly developed strategic development skills.

Excellent business development skills.

Exceptional client management skills with a track record of successful stakeholder engagement and client satisfaction.

Excellent communication, negotiation, and problem-solving skills.

Financial acumen with experience managing project budgets and financial performance.

Ability to work in a fast-paced, dynamic environment with shifting priorities.

Competencies:

Leadership & People Management

Strategic Thinking

Risk & Issue Management

Financial Management

Client Focus

Problem Solving & Decision Making

Cross-functional Collaboration

This role is open to talents in US/EU regions. You must have full unrestricted working rights in USA/EU to be considered for this role as we unfortunately cannot provide sponsorship for this role. 

Salary Band - $200K to $275K USD - Salary offered will be based on candidates' experience level.

Find out more about working at Novotech at: www.novotech-cro.com/careers

Novotech is proud to offer a great workplace. We are committed to being an employer of choice for gender equality and providing an inclusive work environment where everyone is treated fairly and with respect. 

Our team members are passionate about what we do, but we understand work is only of the things that is important to them. We support our team members with flexible working options, paid parental leave for both parents, flexible leave entitlements, wellness programs and ongoing development programs.
 

We are looking for people who are passionate about working clinical research and biotech, including people who identify as LGBTIQ+, have a disability or have caring responsibilities.
 

We are a Circle Back Initiative Employer and commit to respond to every application. We look forward to contacting you regarding your application.