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Overnight Downstream Processing Scientist Jobs (NOW HIRING)

Repligen Corporation

Scientist II

Waltham, MA · On-site

• The Scientist II, Downstream Processing will independently design, execute, and interpret studies to test and characterize new and prototype downstream processing technologies, equipment, and ...

Repligen

Scientist II

Waltham, MA

The Scientist II, Downstream Processing will independently design, execute, and interpret studies to test and characterize new and prototype downstream processing technologies, equipment, and ...

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Overnight Downstream Processing Scientist information

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$36.5K

$79.4K

$137.5K

How much do overnight downstream processing scientist jobs pay per year?

As of Aug 14, 2026, the average yearly pay for overnight downstream processing scientist in the United States is $79,408.00, according to ZipRecruiter salary data. Most workers in this role earn between $57,500.00 and $93,000.00 per year, depending on experience, location, and employer.

What is the difference between Overnight Downstream Processing Scientist vs Downstream Processing Scientist?

AspectOvernight Downstream Processing ScientistDownstream Processing Scientist
Work SchedulePrimarily overnight shifts to support continuous productionStandard daytime shifts
ResponsibilitiesOversees overnight purification and processing steps, ensuring quality and efficiencyHandles overall downstream purification processes during regular hours
CredentialsBachelor's or Master's in Life Sciences, relevant industry certificationsBachelor's or Master's in Life Sciences, similar certifications
Work EnvironmentCleanroom, laboratory, manufacturing facilitiesLaboratory and manufacturing settings

Both roles require similar educational backgrounds and work environments, but the Overnight Downstream Processing Scientist specializes in overnight shift operations to maintain continuous production, whereas the Downstream Processing Scientist typically works during regular hours. The overnight role is crucial for 24/7 manufacturing processes in biotech and pharma industries.

What cities are hiring for Overnight Downstream Processing Scientist jobs?

Cities with the most Overnight Downstream Processing Scientist job openings:

What are the most commonly searched types of Downstream Processing Scientist jobs?

The most popular types of Downstream Processing Scientist jobs are:

What states have the most Overnight Downstream Processing Scientist jobs?

States with the most job openings for Overnight Downstream Processing Scientist jobs include:

Overnight Downstream Processing Scientist jobs near you
Infographic showing various Overnight Downstream Processing Scientist job openings in the United States as of August 2026, with employment types broken down into 80% Full Time, 15% Part Time, 1% Temporary, 3% Contract, and 1% Nights. Highlights an 93% Physical, 2% Hybrid, and 5% Remote job distribution, with an average salary of $79,408 per year, or $38.2 per hour.

Scientist II

Repligen Corporation

Waltham, MA • On-site

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 16 days ago

Repligen rating

7.6

Company rating: 7.6 out of 10

Based on 13 frontline employees who took The Breakroom Quiz

Job description

• The Scientist II, Downstream Processing will independently design, execute, and interpret studies to test and characterize new and prototype downstream processing technologies, equipment, and products for biologics and advanced therapies. This role will generate application data across areas including monoclonal antibodies, recombinant proteins, cell and gene therapies, vaccines, and related modalities, translating experimental findings into clear technical recommendations, application insights, and product performance understanding. The position requires strong scientific judgment, hands-on laboratory execution, cross-functional collaboration, and clear technical communication in support of Repligen's R&D and product development objectives.
Essential Duties and Responsibilities:
  • Design, plan, and execute laboratory studies to test, characterize, and benchmark new or prototype downstream processing technologies, equipment, consumables, and products for biologics and advanced therapies, including mAbs, recombinant proteins, AAV and Lentivirus vectors, vaccines, and related modalities.
  • Generate application data and technical insights for downstream workflows, with strong emphasis on chromatography technologies including resins, membranes, and monoliths, as well as TFF technologies including hollow fiber and cassette-based systems.
  • Operate, program, and troubleshoot lab-scale chromatography systems, including AKTA systems, and lab-scale TFF systems using hollow fibers and cassettes to evaluate product performance under relevant process conditions.
  • Analyze experimental data, interpret technology and product performance, identify trends or limitations, and translate findings into clear technical recommendations, reports, presentations, application data packages, and customer-facing materials.
  • Collaborate with product development, product management and field teams to support product readiness, technical positioning, and adoption of new downstream processing technologies.
  • Prepare, publish, and present application data and technical findings through scientific publications, conference presentations, posters, webinars, and related external scientific communications.
  • Promote safe laboratory practices, data integrity, quality-driven experimentation, and effective technical communication.

Education and/or Work Experience Requirements:
  • Ph.D. in chemical engineering, biochemical engineering, biochemistry, biotechnology, biology, or a related scientific discipline with 2+ years of relevant experience; or M.S. with typically 5+ years; or B.S. with typically 8+ years of relevant industry experience in downstream processing, or a closely related field.
  • Strong technical understanding of downstream processing technologies and unit operations, including chromatography, filtration, clarification, ultrafiltration/diafiltration, sterile filtration, and related process analytical methods for biologics and advanced therapies.
  • Hands-on experience with basic downstream analytical assays and characterization methods such as ELISA, HPLC, SEC-MALS, SDS-PAGE, protein concentration assays, impurity assays, and related product quality or process performance analytics.
  • Demonstrated ability to independently design and execute experiments, interpret complex data, troubleshoot significant technical issues, and communicate recommendations clearly in reports, presentations, protocols, and cross-functional discussions.
  • Experience generating application data or evaluating new bioprocessing technologies, equipment, or consumables in an industrial biotechnology, biopharmaceutical, or life sciences environment is preferred; mammalian cell culture experience is a plus.
  • The candidate must demonstrate critical thinking, be self-motivated, accountable, have excellent organization and communication skills, and demonstrate the ability to work independently and as a member of R&D team.
  • Experienced in fast paced environment with job completion deadlines.

Other Requirements:
  • Ability to work in a laboratory environment and follow established safety procedures, including appropriate use of personal protective equipment.
  • Ability to stand or sit for extended periods while performing laboratory work, data analysis, documentation, and computer-based tasks.
  • Ability to use standard laboratory equipment, handle small tools and instruments, and perform tasks requiring manual dexterity and attention to detail.
  • Ability to lift, move, or carry laboratory materials and equipment up to 25 pounds as needed.
  • Ability to work with chemicals, biological materials, buffers, and process samples in accordance with applicable safety and handling procedures.
  • Ability to travel occasionally to other company sites, collaborators, conferences, or customer locations as business needs require.
  • Flexibility to work extended hours as needed to meet project timelines, typically up to two days per month exceeding 10 hours per day.

Our mission is to inspire advances in bioprocessing as a trusted partner in the production of biologic drugs that improve human health worldwide. Focused on cost and process efficiencies, we deliver innovative technologies and solutions that help set new standards in bioprocessing. The estimated base salary range for this role, based in the United States of America is $113,600-$163,300. Compensation decisions are dependent on several factors including, but not limited to an individual's qualifications, location, internal equity, and alignment with market data. Additionally, employees are eligible to participate in one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits such as paid time off, health/dental/vision, retirement benefits and flexible spending accounts. All compensation and benefits information will be confirmed in writing at the time of offer.

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