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Nextflow Jobs in Berkeley, CA (NOW HIRING)

DevOps Engineer

Pleasanton, CA · On-site

$58.50 - $80.25/hr

Knowledge of Nextflow or other workflow framework * Experience with configuration management tools, such as Ansible or Puppet or Bright * Strong understanding of user interfaces and user experience ...

Principal Software Engineer

South San Francisco, CA · Remote

$162K - $217K/yr

AWS, Kubernetes, Python, Go, Groovy, Terraform, Helm, Nextflow, WDL, Django, React. How You Work * Product-Minded: You think in terms of business and user problems, not tickets. You ask "should we ...

Principal Software Engineer

South San Francisco, CA · On-site

$162K - $217K/yr

AWS, Kubernetes, Python, Go, Groovy, Terraform, Helm, Nextflow, WDL, Django, React. How You Work * Product-Minded: You think in terms of business and user problems, not tickets. You ask "should we ...

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Infographic showing various Nextflow job openings in Berkeley, CA as of August 2026, with employment types broken down into 87% Full Time, 9% Part Time, 2% Temporary, and 2% Contract. Highlights an 76% Physical, 4% Hybrid, and 20% Remote job distribution.

Bioinformatics Engineer, Pipelines

San Francisco, CA • On-site

Full-time

Re-posted 28 days ago


Job description

Job Summary:
Mithrl is building the world’s first commercially available AI Co-Scientist, transforming messy biological data into real insights. The Lead Bioinformatics Pipeline Engineer will design and maintain production-grade bioinformatics pipelines, ensuring accurate data-backed answers for scientists.
Responsibilities:
• Design and maintain production grade bioinformatics pipelines for a wide range of data modalities, including microarray, cell painting, WGS and WES, spatial transcriptomics, flow cytometry, ATAC-seq, and methyl-seq
• Build workflows using Nextflow, nf-core modules, or similar engines with a focus on reproducibility, validation, and scalability
• Implement quality control, validation, and provenance tracking for all supported modalities
• Collaborate with the Tabular Data Team to ensure pipeline outputs map cleanly into Mithrl’s internal schemas, including variable ID coercions, metadata normalization, and feature name harmonization
• Work with the Knowledge Curation Team to align outputs with reference genomes, annotations, and biological ontologies
• Produce structured output artifacts so users can download processed data and supporting metadata directly through the platform
Qualifications:
Required:
• 6 to 8 years of experience in bioinformatics workflow engineering or computational biology
• Strong experience with Nextflow, nf-core, WDL, CWL, Snakemake, or similar workflow systems
• Proficiency in Python or R for data processing, QC, and pipeline logic
• Hands-on experience building pipelines for multiple biological data types, including genomics, single cell, imaging, flow cytometry, spatial data, or epigenomics
• Ability to design pipelines that are reproducible and containerized using Docker or Singularity
• Strong understanding of secondary and tertiary data layers and how they integrate with downstream analysis systems
• Experience integrating pipeline outputs with data stores, schemas, or ML-ready formats
Preferred:
• Experience executing pipelines in cloud environments such as AWS Batch, ECS, Tower, or Nextflow Cloud
• Experience with imaging workflows such as CellProfiler, DeepCell, or Squidpy
• Familiarity with genomic reference databases, annotation formats, and biological ontologies
• Previous work in a tech bio startup, biotech R&D group, or scientific software company
Company:
Mithrl is a software development company that builds the custom workflows for NGS data on-demand. Founded in 2023, the company is headquartered in San Francisco, USA, with a team of 51-200 employees. The company is currently Early Stage.