... rational mutagenesis, etc.) * Computational expertise in NGS data analysis. * Working knowledge of structural biology, T cell and B cell biology, cancer immunology and immuno-oncology. At ...
... rational mutagenesis, etc.) * Computational expertise in NGS data analysis. * Working knowledge of structural biology, T cell and B cell biology, cancer immunology and immuno-oncology. At ...
... rational mutagenesis, etc.) * Computational expertise in NGS data analysis. * Working knowledge of structural biology, T cell and B cell biology, cancer immunology and immuno-oncology. At ...
Quick apply
... rational mutagenesis, etc.) * Computational expertise in NGS data analysis. * Working knowledge of structural biology, T cell and B cell biology, cancer immunology and immuno-oncology. At ...
Typical laboratory techniques often require expertise with gene expression analysis, targeted mutagenesis, microscopy, bacterial community analysis, and multiple `omics analysis. Demonstrable ...
Typical laboratory techniques often require expertise with gene expression analysis, targeted mutagenesis, microscopy, bacterial community analysis, and multiple `omics analysis. Demonstrable ...
Postdoctoral Scholar
Portland, OR · On-site
Typical laboratory techniques often require expertise with gene expression analysis, targeted mutagenesis, microscopy, bacterial community analysis, and multiple `omics analysis. Demonstrable ...
Postdoctoral Scholar
Portland, OR · On-site
Typical laboratory techniques often require expertise with gene expression analysis, targeted mutagenesis, microscopy, bacterial community analysis, and multiple `omics analysis. Demonstrable ...
Software Engineer II
$112K - $154K/yr
We also derive novel strains through random mutagenesis and directed evolution. Using our custom control platform, we then subject these experimental organisms to high throughput performance ...
Quick apply
Software Engineer II
$112K - $154K/yr
We also derive novel strains through random mutagenesis and directed evolution. Using our custom control platform, we then subject these experimental organisms to high throughput performance ...
Typical laboratory techniques often require expertise with gene expression analysis, targeted mutagenesis, microscopy, bacterial community analysis, and multiple `omics analysis. Demonstrable ...
Typical laboratory techniques often require expertise with gene expression analysis, targeted mutagenesis, microscopy, bacterial community analysis, and multiple `omics analysis. Demonstrable ...
Lab and Research Technician 2, Pharmacology
Charlottesville, VA · On-site
$40K - $50K/yr
Perform standard molecular biology (transformation, plasmid preparation, mutagenesis, and sub-cloning). * Learn/implement cell culture approaches for preparation of viral constructs. * Perform a ...
Lab and Research Technician 2, Pharmacology
Charlottesville, VA · On-site
$40K - $50K/yr
Perform standard molecular biology (transformation, plasmid preparation, mutagenesis, and sub-cloning). * Learn/implement cell culture approaches for preparation of viral constructs. * Perform a ...
Postdoctoral Scholar
Portland, OR · On-site
Typical laboratory techniques often require expertise with gene expression analysis, targeted mutagenesis, microscopy, bacterial community analysis, and multiple `omics analysis. Demonstrable ...
Postdoctoral Scholar
Portland, OR · On-site
Typical laboratory techniques often require expertise with gene expression analysis, targeted mutagenesis, microscopy, bacterial community analysis, and multiple `omics analysis. Demonstrable ...
Research Associate
San Francisco, CA · On-site
$95K - $120K/yr
Molecular biology (cloning, mutagenesis, plasmid prep) * Protein biochemistry (expression, purification, assays) * Cell biology (culture, transfection, imaging) * Neuroscience (in vivo experiments ...
Research Associate
San Francisco, CA · On-site
$95K - $120K/yr
Molecular biology (cloning, mutagenesis, plasmid prep) * Protein biochemistry (expression, purification, assays) * Cell biology (culture, transfection, imaging) * Neuroscience (in vivo experiments ...
Research Fellow-LS-Dr Kun Ling-BMB
Rochester, MN · On-site
Medical
Dental
Vision
Retirement
Common molecular and cellular techniques are required, including molecular cloning, mutagenesis, cell culture and transfection, and immunoblotting. Experience on recombinant protein expression and ...
Research Fellow-LS-Dr Kun Ling-BMB
Rochester, MN · On-site
Medical
Dental
Vision
Retirement
Common molecular and cellular techniques are required, including molecular cloning, mutagenesis, cell culture and transfection, and immunoblotting. Experience on recombinant protein expression and ...
Research Associate - Systems Biology & Phage Therapy (Silas Lab)
Medical
Dental
Vision
Retirement
PTO
Whole genome transposon mutagenesis Additional responsibilities include: * Maintaining rigorous sample tracking and organization across numerous parallel workflows * Leading and meticulously ...
Research Associate - Systems Biology & Phage Therapy (Silas Lab)
Medical
Dental
Vision
Retirement
PTO
Whole genome transposon mutagenesis Additional responsibilities include: * Maintaining rigorous sample tracking and organization across numerous parallel workflows * Leading and meticulously ...
Director, Protein Sciences
Cambridge, MA · On-site
Retirement
PTO
Homology modeling, structural analysis, and rational mutagenesis * Integration of emerging AI/ML-based protein design tools Engineer proteins to improve: * Stability and expression * Functional ...
Director, Protein Sciences
Cambridge, MA · On-site
Retirement
PTO
Homology modeling, structural analysis, and rational mutagenesis * Integration of emerging AI/ML-based protein design tools Engineer proteins to improve: * Stability and expression * Functional ...
Research includes but is not limited to: in vitro cell culture experiments, transport assays, Western Blotting, cloning and mutagenesis, immunohistochemical imaging and live cell imaging, LC-MS/MS ...
Research includes but is not limited to: in vitro cell culture experiments, transport assays, Western Blotting, cloning and mutagenesis, immunohistochemical imaging and live cell imaging, LC-MS/MS ...
Post Doctoral Fellow
Atlanta, GA · On-site
$47K - $64K/yr
Molecular cloning (mutagenesis, lentiviral vectors) * Cell culture (cell lines, primary cells) * Mouse experience (handling mice, tissue harvest) * Molecular biology methods (Western blot, microscopy ...
Post Doctoral Fellow
Atlanta, GA · On-site
$47K - $64K/yr
Molecular cloning (mutagenesis, lentiviral vectors) * Cell culture (cell lines, primary cells) * Mouse experience (handling mice, tissue harvest) * Molecular biology methods (Western blot, microscopy ...
Research includes but is not limited to: in vitro cell culture experiments, transport assays, Western Blotting, cloning and mutagenesis, immunohistochemical imaging and live cell imaging, LC-MS/MS ...
Research includes but is not limited to: in vitro cell culture experiments, transport assays, Western Blotting, cloning and mutagenesis, immunohistochemical imaging and live cell imaging, LC-MS/MS ...
Molecular cloning (plasmid preparation, mutagenesis, lentiviral vectors). * Sample tracking, data entry, and basic data analysis. * Laboratory operations (ordering, inventory, equipment maintenance)
Molecular cloning (plasmid preparation, mutagenesis, lentiviral vectors). * Sample tracking, data entry, and basic data analysis. * Laboratory operations (ordering, inventory, equipment maintenance)
Research Technician - Horvitz Lab
Cambridgeport, MA · On-site
$18.40 - $23/hr
Medical
Retirement
Mutagenesis screens * C. elegans strain creation (genetic crosses, CRISPR, transgenesis, PCR genotyping, etc .) * Molecular cloning * Microscopy (e.g., imaging fluorescent proteins in C. elegans
Research Technician - Horvitz Lab
Cambridgeport, MA · On-site
$18.40 - $23/hr
Medical
Retirement
Mutagenesis screens * C. elegans strain creation (genetic crosses, CRISPR, transgenesis, PCR genotyping, etc .) * Molecular cloning * Microscopy (e.g., imaging fluorescent proteins in C. elegans
Molecular cloning (plasmid preparation, mutagenesis, lentiviral vectors). * Sample tracking, data entry, and basic data analysis. * Laboratory operations (ordering, inventory, equipment maintenance)
Molecular cloning (plasmid preparation, mutagenesis, lentiviral vectors). * Sample tracking, data entry, and basic data analysis. * Laboratory operations (ordering, inventory, equipment maintenance)
Post Doctoral Associate
Pittsburgh, PA · On-site
Design and execute experiments involving cloning, site-directed mutagenesis, CRISPR/Cas9-based approaches, receptor signaling assays, binding assays, and cellular functional assays. Structural ...
Post Doctoral Associate
Pittsburgh, PA · On-site
Design and execute experiments involving cloning, site-directed mutagenesis, CRISPR/Cas9-based approaches, receptor signaling assays, binding assays, and cellular functional assays. Structural ...
Researcher 1- IDIM
$42K - $43K/yr
Medical
Dental
Life
Retirement
... mutagenesis, and to screen libraries of antibodies on cell surface. 20%- Lab Administration and Analysis Duties include maintenance of scientific equipment, making buffers and solutions, running ...
Researcher 1- IDIM
$42K - $43K/yr
Medical
Dental
Life
Retirement
... mutagenesis, and to screen libraries of antibodies on cell surface. 20%- Lab Administration and Analysis Duties include maintenance of scientific equipment, making buffers and solutions, running ...
Mutagenesis information
What are the key skills and qualifications needed to thrive as a mutagenesis scientist, and why are they important?
To thrive as a Mutagenesis Scientist, you need a strong background in molecular biology, genetics, and laboratory techniques, typically supported by an advanced degree in biological sciences. Experience with CRISPR, site-directed mutagenesis kits, PCR, and DNA sequencing platforms is essential. Attention to detail, critical thinking, and effective teamwork are valuable soft skills in this role. These skills ensure accurate genetic modifications, reliable experimental results, and successful collaboration on research projects.
What is the difference between Mutagenesis vs Genetic Engineer?
| Aspect | Mutagenesis | Genetic Engineer |
|---|---|---|
| Required Credentials | Laboratory skills, knowledge of molecular biology, often a bachelor's or master's degree | Advanced degrees (Master's or PhD), expertise in genetic modification techniques |
| Work Environment | Research labs, biotech companies, pharmaceutical labs | Research institutions, biotech firms, pharmaceutical companies |
| Industry Usage | Used for creating genetic variations, studying mutations | Designing and implementing genetic modifications in organisms |
| Common Search/Comparison | Mutagenesis vs Genetic Engineer |
Mutagenesis involves inducing mutations to study gene functions or create genetic diversity, often using chemical or physical agents. Genetic engineers design and implement specific genetic modifications using advanced techniques like CRISPR. While mutagenesis is more about random mutation induction, genetic engineering focuses on precise gene editing. Both roles are essential in biotechnology and share overlapping skills, but differ in complexity and purpose.
What are some typical challenges faced by scientists working in mutagenesis, and how can they be addressed?
Scientists specializing in mutagenesis often encounter challenges such as ensuring the specificity of induced mutations and accurately screening for desired genetic changes. Maintaining the viability of organisms while introducing mutations and avoiding off-target effects are also common concerns. These issues can be addressed by carefully selecting mutagenic agents, optimizing experimental protocols, and using advanced screening techniques such as next-generation sequencing. Collaboration with bioinformatics specialists and molecular biologists is also essential to interpret results and refine approaches.
What is mutagenesis?
Mutagenesis is a process by which the genetic information of an organism is changed in a stable manner, resulting in a mutation. This can occur naturally or be induced artificially in a laboratory, often using chemicals, radiation, or genetic engineering techniques. Scientists use mutagenesis to study gene function, create genetic diversity, or develop organisms with desirable traits. In research, mutagenesis helps identify the roles of specific genes and understand the effects of genetic changes.
More about Mutagenesis jobs
What job categories do people searching Mutagenesis jobs look for?
The top searched job categories for Mutagenesis jobs are:
Full-time
Posted 16 days ago
Job description
Position Summary:
PharmaEssentia Innovation Research Center (PIRC) is seeking a highly motivated and collaborative Scientist I, Biochemistry and Biotherapeutics to join the Biologics Platform team. The successful candidate will support discovery and early development of innovative therapeutics, including antibodies, multi-specifics, T cell engagers and cytokines. This role will focus on the discovery, characterization, and optimization of lead candidates through integrated protein engineering, biophysical and mechanism-of-action studies. The ideal candidate will bring a strong foundation in protein biochemistry with hands-on experience in phage, yeast, or mammalian display and/or AI-assisted protein design for antibody discovery and optimization. The ideal candidate is also a technical expert in evaluating biotherapeutics via SPR, BLI, ELISA, flow cytometry and immuno-assays. As a valued contributor to a growing and dynamic team, this individual will help drive our mission to develop transformative therapies for patients.
Summary of Key Responsibilities:
Essential Qualifications:
Preferred Qualifications:
At PharmaEssentia, our goal is to treat as many people with cancer as possible. That means challenging the status quo with better science that leads to better lives. By joining our team, you will not only expand your own possibilities, but you will contribute to expanding options for people with cancer.
https://us.pharmaessentia.com/careers/
PharmaEssentia Innovation Research Center (PIRC) is seeking a highly motivated and collaborative Scientist I, Biochemistry and Biotherapeutics to join the Biologics Platform team. The successful candidate will support discovery and early development of innovative therapeutics, including antibodies, multi-specifics, T cell engagers and cytokines. This role will focus on the discovery, characterization, and optimization of lead candidates through integrated protein engineering, biophysical and mechanism-of-action studies. The ideal candidate will bring a strong foundation in protein biochemistry with hands-on experience in phage, yeast, or mammalian display and/or AI-assisted protein design for antibody discovery and optimization. The ideal candidate is also a technical expert in evaluating biotherapeutics via SPR, BLI, ELISA, flow cytometry and immuno-assays. As a valued contributor to a growing and dynamic team, this individual will help drive our mission to develop transformative therapies for patients.
Summary of Key Responsibilities:
- Contribute to pipeline program and discovery project workstreams supporting target validation, candidate selection, and lead candidate optimization
- Collaborate with internal research teams, external partners, and CROs to integrate experimental data with candidate selection criteria
- Prepare high-quality internal presentations, scientific reports, external publications, or conference presentations, as appropriate
- Stay current with emerging advances in immuno-oncology and relevant therapeutic modalities and communicate key findings internally
- Provide scientific input within project teams and support the training or mentorship of junior team members
Essential Qualifications:
- PhD in Biochemistry, Biophysics, Immunology or a related scientific discipline, with 0-2 years of relevant post-PhD experience in an industry or academic research setting
- Hands-on experience with antibody discovery and optimization via combinatorial library-based technologies such as phage, yeast or mammalian display
- Experience with antibody, multi-specific, or other protein-based therapeutics, including formatting, production and high-throughput characterization via affinity (SPR, BLI, Carterra), epitope, developability and cellular functional assays (cytotoxicity, antibody internalization, MSD assay)
- Demonstrated ability to independently advance scientific projects, collaborate cross-functionally, and communicate scientific findings clearly through written reports, presentations, publications, patents, or related scientific outputs
- Proficiency with data analysis and molecular biology software, such as FlowJo, GraphPad Prism, Geneious, Snapgene, etc
- Collaborative, flexible, and team-oriented mindset, with the ability to contribute effectively within a dynamic research environment
Preferred Qualifications:
- Working knowledge of emerging and established protein engineering technologies such as AI/ML-based protein design and optimization (RFdiffusion, pMPNN, AlphaFold, Rosetta, MOE, structure-based rational mutagenesis, etc.)
- Computational expertise in NGS data analysis.
- Working knowledge of structural biology, T cell and B cell biology, cancer immunology and immuno-oncology.
At PharmaEssentia, our goal is to treat as many people with cancer as possible. That means challenging the status quo with better science that leads to better lives. By joining our team, you will not only expand your own possibilities, but you will contribute to expanding options for people with cancer.
https://us.pharmaessentia.com/careers/