Postdoctoral Researcher in Mutagenesis, Population and Statistical Genetics A postdoctoral training opportunity is now available in the Seplyarskiy Lab in the McDermott Center for Human Growth and ...
Postdoctoral Researcher in Mutagenesis, Population and Statistical Genetics A postdoctoral training opportunity is now available in the Seplyarskiy Lab in the McDermott Center for Human Growth and ...
POSTDOCTORAL RESEARCHER - McDermott Center HG&D - Seplyarskiy Lab [Req#: 911441, Position#: 127940]
Dallas, TX · On-site
$114K/yr
Description Postdoctoral Researcher in Mutagenesis, Population and Statistical Genetics A postdoctoral training opportunity is now available in the Seplyarskiy Lab in the McDermott Center for Human ...
POSTDOCTORAL RESEARCHER - McDermott Center HG&D - Seplyarskiy Lab [Req#: 911441, Position#: 127940]
Dallas, TX · On-site
$114K/yr
Description Postdoctoral Researcher in Mutagenesis, Population and Statistical Genetics A postdoctoral training opportunity is now available in the Seplyarskiy Lab in the McDermott Center for Human ...
Proven expertise in molecular biology (cloning, construct design, mutagenesis). * Hands-on experience in protein purification of GPCRs using FPLC (affinity, SEC). * Familiarity with protein ...
Proven expertise in molecular biology (cloning, construct design, mutagenesis). * Hands-on experience in protein purification of GPCRs using FPLC (affinity, SEC). * Familiarity with protein ...
Research Technician
Tucson, AZ · On-site
$17 - $23.50/hr
Cloning DNA constructs for mutagenesis, CRISPR KI/KO, and protein expression. * Tissue culture. * PCR, qPCR, western blot, etc. * High throughput assay for cytotoxicity, redox assessment, etc.
Research Technician
Tucson, AZ · On-site
$17 - $23.50/hr
Cloning DNA constructs for mutagenesis, CRISPR KI/KO, and protein expression. * Tissue culture. * PCR, qPCR, western blot, etc. * High throughput assay for cytotoxicity, redox assessment, etc.
Molecular Biologist (R6 - R7)
San Diego, CA · On-site
$135K - $172K/yr
Design and construct comprehensive mutagenesis libraries for deep scanning mutagenesis libraries. Implement and optimize high throughput cloning and expression strategies in yeast and mammalian ...
Molecular Biologist (R6 - R7)
San Diego, CA · On-site
$135K - $172K/yr
Design and construct comprehensive mutagenesis libraries for deep scanning mutagenesis libraries. Implement and optimize high throughput cloning and expression strategies in yeast and mammalian ...
Molecular Biologist (R6 - R7)
$135K - $172K/yr
Design and construct comprehensive mutagenesis libraries for deep scanning mutagenesis libraries. Implement and optimize high throughput cloning and expression strategies in yeast and mammalian ...
Molecular Biologist (R6 - R7)
$135K - $172K/yr
Design and construct comprehensive mutagenesis libraries for deep scanning mutagenesis libraries. Implement and optimize high throughput cloning and expression strategies in yeast and mammalian ...
Postdoctoral Associate Position - Functional Genomics / Regulatory Genomics / Human Evolution & Dise
New Haven, CT · On-site
Use saturation mutagenesis paired with machine-learning models to understand the rules by which CREs regulate gene expression. * Interrogating Genetic Architectures: Explore how combinations of ...
Postdoctoral Associate Position - Functional Genomics / Regulatory Genomics / Human Evolution & Dise
New Haven, CT · On-site
Use saturation mutagenesis paired with machine-learning models to understand the rules by which CREs regulate gene expression. * Interrogating Genetic Architectures: Explore how combinations of ...
Postdoctoral Research Associate
Omaha, NE · On-site
... Mutagenesis, with particular focus on the origin on mutations that cause human diseases. Required Qualifications Ph.D. degree in genetics, biochemistry, molecular biology or related field.
Postdoctoral Research Associate
Omaha, NE · On-site
... Mutagenesis, with particular focus on the origin on mutations that cause human diseases. Required Qualifications Ph.D. degree in genetics, biochemistry, molecular biology or related field.
... Mutagenesis, with particular focus on the origin on mutations that cause human diseases. Required Qualifications Ph.D. degree in genetics, biochemistry, molecular biology or related field.
... Mutagenesis, with particular focus on the origin on mutations that cause human diseases. Required Qualifications Ph.D. degree in genetics, biochemistry, molecular biology or related field.
Scientist/Senior Scientist, Antibody Engineering
San Diego, CA · On-site
$120K - $150K/yr
Perform molecular cloning, mutagenesis, antibody gene assembly, and expression vector design. * Express and purify recombinant antibodies using bacterial and mammalian expression systems. * Perform ...
Scientist/Senior Scientist, Antibody Engineering
San Diego, CA · On-site
$120K - $150K/yr
Perform molecular cloning, mutagenesis, antibody gene assembly, and expression vector design. * Express and purify recombinant antibodies using bacterial and mammalian expression systems. * Perform ...
... Mutagenesis, with particular focus on the origin on mutations that cause human diseases. Required Qualifications Ph.D. degree in genetics, biochemistry, molecular biology or related field.
... Mutagenesis, with particular focus on the origin on mutations that cause human diseases. Required Qualifications Ph.D. degree in genetics, biochemistry, molecular biology or related field.
PCR, Gibson/Golden Gate assembly, mutagenesis, bacterial transformation, plasmid preparation, and sequence verification. Protein production: bacterial expression, affinity purification ...
PCR, Gibson/Golden Gate assembly, mutagenesis, bacterial transformation, plasmid preparation, and sequence verification. Protein production: bacterial expression, affinity purification ...
Automated Antibody Engineering Scientist
Westbrook, ME · On-site
$35.75 - $45/hr
Design and execute molecular biology workflows for antigen and antibody construct development, including primer design, PCR-based cloning, site-directed mutagenesis, and sequence verification.
Automated Antibody Engineering Scientist
Westbrook, ME · On-site
$35.75 - $45/hr
Design and execute molecular biology workflows for antigen and antibody construct development, including primer design, PCR-based cloning, site-directed mutagenesis, and sequence verification.
Research Scientist/Engr 1
Seattle, WA · On-site
$58K/yr
PCR, Gibson/Golden Gate assembly, mutagenesis, bacterial transformation, plasmid preparation, and sequence verification. • Protein production: bacterial expression, affinity purification ...
Research Scientist/Engr 1
Seattle, WA · On-site
$58K/yr
PCR, Gibson/Golden Gate assembly, mutagenesis, bacterial transformation, plasmid preparation, and sequence verification. • Protein production: bacterial expression, affinity purification ...
Proven expertise in molecular biology (cloning, construct design, mutagenesis). * Hands-on experience in protein purification of GPCRs using FPLC (affinity, SEC). * Familiarity with protein ...
Proven expertise in molecular biology (cloning, construct design, mutagenesis). * Hands-on experience in protein purification of GPCRs using FPLC (affinity, SEC). * Familiarity with protein ...
Scientist/Senior Scientist, Antibody Engineering
San Diego, CA · On-site
$120K - $150K/yr
Perform molecular cloning, mutagenesis, antibody gene assembly, and expression vector design. * Express and purify recombinant antibodies using bacterial and mammalian expression systems. * Perform ...
Quick apply
Scientist/Senior Scientist, Antibody Engineering
San Diego, CA · On-site
$120K - $150K/yr
Perform molecular cloning, mutagenesis, antibody gene assembly, and expression vector design. * Express and purify recombinant antibodies using bacterial and mammalian expression systems. * Perform ...
Automated Antibody Engineering Scientist
$35.75 - $45/hr
Design and execute molecular biology workflows for antigen and antibody construct development, including primer design, PCR-based cloning, site-directed mutagenesis, and sequence verification.
Automated Antibody Engineering Scientist
$35.75 - $45/hr
Design and execute molecular biology workflows for antigen and antibody construct development, including primer design, PCR-based cloning, site-directed mutagenesis, and sequence verification.
Experience in molecular biology, including PCR, DNA subcloning, and site directed mutagenesis a plus. Knowledge, Experience and Skills: * BS degree with 4+ years of experience or MS degree with 2+ ...
Experience in molecular biology, including PCR, DNA subcloning, and site directed mutagenesis a plus. Knowledge, Experience and Skills: * BS degree with 4+ years of experience or MS degree with 2+ ...
Scientist, GPCR Biology - San Diego, CA
San Diego, CA · On-site
$10K - $140K/yr
Strong molecular biology (cloning, transfection, construct design, mutagenesis) and mammalian cell culture skills, with a track record of building reliable cell-based assays. * Expertise with taste ...
Scientist, GPCR Biology - San Diego, CA
San Diego, CA · On-site
$10K - $140K/yr
Strong molecular biology (cloning, transfection, construct design, mutagenesis) and mammalian cell culture skills, with a track record of building reliable cell-based assays. * Expertise with taste ...
Research Technician
Tucson, AZ · On-site
$16.50 - $18.75/hr
Cloning DNA constructs for mutagenesis, CRISPR KI/KO, and protein expression. * Tissue culture. * PCR, qPCR, western blot, etc. * High throughput assay for cytotoxicity, redox assessment, etc.
Research Technician
Tucson, AZ · On-site
$16.50 - $18.75/hr
Cloning DNA constructs for mutagenesis, CRISPR KI/KO, and protein expression. * Tissue culture. * PCR, qPCR, western blot, etc. * High throughput assay for cytotoxicity, redox assessment, etc.
Mutagenesis information
What jobs in the US pay 300,000 a year?
What are the key skills and qualifications needed to thrive as a Mutagenesis Scientist, and why are they important?
What biology jobs pay over $100k?
What is the difference between Mutagenesis vs Genetic Engineer?
| Aspect | Mutagenesis | Genetic Engineer |
|---|---|---|
| Required Credentials | Laboratory skills, knowledge of molecular biology, often a bachelor's or master's degree | Advanced degrees (Master's or PhD), expertise in genetic modification techniques |
| Work Environment | Research labs, biotech companies, pharmaceutical labs | Research institutions, biotech firms, pharmaceutical companies |
| Industry Usage | Used for creating genetic variations, studying mutations | Designing and implementing genetic modifications in organisms |
| Common Search/Comparison | Mutagenesis vs Genetic Engineer |
Mutagenesis involves inducing mutations to study gene functions or create genetic diversity, often using chemical or physical agents. Genetic engineers design and implement specific genetic modifications using advanced techniques like CRISPR. While mutagenesis is more about random mutation induction, genetic engineering focuses on precise gene editing. Both roles are essential in biotechnology and share overlapping skills, but differ in complexity and purpose.
What are some typical challenges faced by scientists working in mutagenesis, and how can they be addressed?
What is the highest paying job in genetics?
What are the applications of mutagenesis?
What is mutagenesis?

POSTDOCTORAL RESEARCHER - McDermott Center HG&D - Seplyarskiy Lab
Dallas, TX • On-site
$114K/yr
Other
Medical, Retirement, PTO
Re-posted 17 days ago
UT Southwestern rating
8.0
Based on 150 frontline employees who took The Breakroom Quiz
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Job description
Postdoctoral Researcher in Mutagenesis, Population and Statistical Genetics
A postdoctoral training opportunity is now available in the Seplyarskiy Lab in the McDermott Center for Human Growth and Development at UT Southwestern Medical Center at Dallas. We are currently accepting applications for a postdoctoral fellowship in mutagenesis, statistical genomics, and computational biology.
Research directions
- Mutagenesis: evolution of mutational mechanisms across the tree of life; somatic mutagenesis and clonal dynamics; reconstruction of early developmental lineages from mosaic mutations.
- Population genetics: quantifying recurrence and number of mutational origins in large cohorts; discovery of strongly selected sites and constraint from recurrence-aware models.
- Statistical genetics: partitioning heritability and enrichment in DNA-repair and mutagenesis pathways (including cancer-relevant contexts); development of mutation rate model
Training & environment
- Close mentorship in mutagenesis, population genetics, and statistical genetics
- Active joint journal clubs with external groups (Ziyue Gao - UPenn, Evan Koch - Yale), collaborative community at UTSW's McDermott Center.
- Access to large datasets (e.g., biobanks, gnomAD-class resources) and compute.
Responsibilities
- Formulate and test new quantitative models of mutation, selection, and clonal evolution.
- Develop methods tailored to large-scale genomic datasets.
- Lead analyses, interpret results and drive manuscripts to completion.
- Collaborate on related work across the lab's projects.
Ph.D. (or equivalent, or soon to be completed) in Statistics, Biostatistics, Computer Science, Population/Statistical Genetics, Bioinformatics/Computational Biology
Proficiency in R and/or Python/ or other languages
Plus factors: experience with method development, exposure to population-genetic theory (selection, demography, coalescent/ARG), mutational-process modeling, scalable data engineering, cloud/HPC, or ancient DNA.
Interested individuals should send a CV, cover letter briefly describing previous research experience, and a summary of current research interests.
UTSouthwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. Asan equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis ofrace, color, religion, national origin, sex,sexual orientation, gender identity, gender expression,age, disability, genetic information, citizenship status, or veteran status.
This position is security-sensitive and subject to Texas Education Code 51.215, which authorizes UT Southwestern to obtain criminal history record information.
Appointment rank will be commensurate with academic accomplishment and experience. Consideration may be given to applicants seeking less than a full-time schedule.
To learn more about the benefits UT Southwestern offers, visithttps://www.utsouthwestern.edu/employees/hr-resources/
- UT Southwestern is proud to offer a competitive and comprehensive benefits package to eligible employees. Our benefits are designed to support your overall wellbeing, and include:
- PPO medical plan, available day one at no cost for full-time employee-only coverage
- 100% coverage for preventive healthcare - no copay
- Paid Time Off, available day one
- Retirement Programs through the Teacher Retirement System of Texas (TRS)
- Paid Parental Leave Benefit
- Wellness programs
- Tuition Reimbursement
- Public Service Loan Forgiveness (PSLF) Qualified Employer
- Learn more about these and other UTSW employee benefits!
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About UT Southwestern
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Industry
Hospitals
Company size
10,000+ Employees
Headquarters location
Dallas, TX, US
Year founded
1943