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The Mayo Clinic Department of Neuroscience is recruiting an exceptional scientist (PhD, MD/PhD, MD or equivalent) who is a leading expert in neurodegenerative and related diseases to establish a robust research program at Mayo Clinic. The candidate is expected to have an outstanding track record in innovative scientific discovery with strong translational component in areas including biomarker discoveries, novel therapeutic approaches such as RNA and cellular therapies, utilizing human data, biospecimens and model systems to accelerate discoveries toward disease-modifying therapies and cures. This individual will integrate efforts across sites and disciplines such as Neuroscience, Neurology, Artificial Intelligence and Pathology and Laboratory Medicine to leverage large-scale human datasets and biospecimens. By combining expertise in human disease biology, model systems, brain health, and aging, this scientist will uncover key disease mechanisms and drive predictive and therapeutic advances in neurodegenerative and related disorders. The ideal candidate will have a track record of basic and translational science discoveries, experience engaging with business development, and will be poised to take advantage of large-scale, multi-PI research opportunities from the National Institutes of Health (NIH), ARPA and other funding agencies. The candidate will be eligible for all faculty privileges and be involved in the education of trainees. 

 Qualifications 

The candidate will have strong expertise and experience in basic and translational research in neurodegeneration and related disorders, brain health and disease, from mechanisms to cures.  The ideal candidate is expected to have a history of extramural funding, high impact publications, as well as a proven record of collaborative team science endeavors. This scientist will have a track record of basic and translational science research approaches including but not limited to model systems such as animal or human stem cell-based models, cell biology, and/or genetic engineering to uncover biological basis of disease and treatment thereof. The candidate will be expected to develop and apply these tools for generating diagnostic, prognostic, preventative or therapeutic applications in collaboration with other investigators and taking advantage of the innovative, translational environment at Mayo Clinic. The required qualifications include the following: 

• Ph.D., M.D., M.D./Ph.D. or equivalent degree in a relevant discipline 

• Academic rank of Associate Professor or Professor, or equivalent rank 

• Proven track record of robust, sustained and current grant funding from the National Institutes of Health (NIH) and other federal agencies and national/international renown  

• An exceptional and innovative investigator (physician-scientist or scientist) with demonstrated scientific excellence and previous leadership/administrative/management experience in academic medicine or biopharma 

The position will be located at the Mayo Clinic Florida site in Jacksonville. 

The Department of Neuroscience 

The Department of Neuroscience is internationally recognized for academic excellence with a specific focus on understanding the etiology and developing diagnostic and treatment methods for complex neurologic diseases, including neurodegenerative dementias, movement, neurovascular, neuroimmune disorders and aging. The Department spans all Mayo Clinic sites and includes 28 primary and 12 joint faculty members, 58 allied health staff, 57 postdoctoral associates, and 53 doctoral students. Scientists within the neuroscience department have strong expertise in neurogenomics, neuropathology, disease modeling, molecular and cell biology, immunity, and experimental therapeutics. The Department faculty play key roles in the Alzheimer's Disease Research Center and other large-scale NIH-funded consortia. In 2025, the total cost of grant funding to the Department of Neuroscience was $284M, the majority of which was from federal grants. Our faculty holds leadership roles on major NIH and foundation programs including but not limited to AMP-AD, CLEAR-AD, Dementia with Lewy Bodies Consortium, Tau Center without walls. 

Highlights of Mayo Clinic Research Enterprise: