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Mes Application Engineer Jobs (NOW HIRING)

PharmEng Technology Americas

MES Engineer

San Juan, PR · Remote

The MES Application Engineer is responsible for supporting activities such as requirements gathering, definition, and application/test/implementation of Manufacturing Execution System (MES) client ...

Atria Group LLC

Apriso FlexNet

Cleveland, OH

Apriso FlexNet MES Microsoft Technologies * Database Oracle or MS SQL & CC programming * MES application Upgrade * Implementation Support * Control System * MES ERP Integration * Knowledge of ...

USI INC

R26-0015 - IT MES Developer

Milpitas, CA · On-site

$80K - $125K/yr

We are seeking a motivated and detail-oriented IT MES Developer to support the development ... Training, production support, system improvements, report development, and MES application updates ...

Rhino Tool House

Application Engineer

Davenport, IA · On-site

$75K - $85K/yr

We are seeking a dynamic and technically skilled Application Engineer to support and grow our ... Manufacturing Execution Systems (MES) * Automated Guided Vehicles (AGVs) / Autonomous Mobile Robots ...

Pacer Group

TrakSYS Support Engineer

Richmond, VA · On-site

$61/hr

TrakSYS Support Engineer Job location: Richmond, VA Job Duration: 3 Months Contract to Hire Job ... Provide Level 1 / Level 2 Support for TrakSYS MES application. * Monitor system performance and ...

Right Skale, Inc.

Apriso Senior Developer

$55.75 - $73.75/hr

Apriso Senior Developer - Contract W2 - Remote (US based) Key Responsibilities: * Work with the ... ensure the MES application is running business as usual, as well as possible enhancement of ...

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Mes Application Engineer information

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$50.5K

$110.7K

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How much do mes application engineer jobs pay per year?

As of Jun 5, 2026, the average yearly pay for mes application engineer in the United States is $110,698.00, according to ZipRecruiter salary data. Most workers in this role earn between $84,000.00 and $135,000.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a MES Application Engineer, and why are they important?

To thrive as a MES Application Engineer, you need a solid background in computer science or engineering, experience with manufacturing processes, and knowledge of Manufacturing Execution Systems (MES) such as Siemens Opcenter or Rockwell FactoryTalk. Familiarity with programming languages (e.g., SQL, Java), database management, and system integration tools is often required, along with relevant certifications. Strong problem-solving abilities, effective communication, and project management skills help you collaborate with cross-functional teams and address client needs. These competencies ensure MES solutions are effectively implemented, optimized, and maintained to support efficient manufacturing operations.

What are some common challenges MES Application Engineers face when integrating MES solutions with existing manufacturing systems?

MES Application Engineers often encounter challenges when integrating Manufacturing Execution Systems (MES) with legacy equipment and diverse software platforms. Ensuring seamless data flow between the MES and systems like ERP or SCADA can require custom interfaces and thorough testing. Additionally, aligning the MES solution with unique production processes and minimizing downtime during implementation are frequent concerns. Strong collaboration with IT, production, and engineering teams is essential to address these integration hurdles effectively.

What is the difference between Mes Application Engineer vs Manufacturing Engineer?

AspectMes Application EngineerManufacturing Engineer
Required CredentialsBachelor's in Engineering, knowledge of MES systemsBachelor's in Mechanical, Industrial, or Manufacturing Engineering
Work EnvironmentSoftware-focused, working with MES platforms and production teamsFactory floor, process optimization, equipment and workflow design
Employer & Industry UsageManufacturing companies implementing MES solutionsManufacturing plants across various industries
Common Search & ComparisonYesYes

The Mes Application Engineer primarily focuses on implementing and supporting Manufacturing Execution Systems (MES) to optimize production processes. In contrast, Manufacturing Engineers concentrate on designing, improving, and maintaining manufacturing processes and equipment. While both roles work within manufacturing environments, the Mes Application Engineer is more software and system-oriented, whereas the Manufacturing Engineer emphasizes process and equipment optimization.

What is a MES Application Engineer?

A MES (Manufacturing Execution System) Application Engineer is a professional who designs, implements, and maintains MES software solutions for manufacturing operations. They bridge the gap between production floor systems and enterprise-level software, ensuring real-time monitoring, data collection, and process optimization. Their role typically involves configuring MES applications, integrating them with other systems like ERP, troubleshooting issues, and supporting ongoing improvements for manufacturing efficiency and quality. MES Application Engineers often work closely with IT, operations, and engineering teams to meet production goals and compliance requirements.
What cities are hiring for Mes Application Engineer jobs? Cities with the most Mes Application Engineer job openings:
What states have the most Mes Application Engineer jobs? States with the most job openings for Mes Application Engineer jobs include:
Infographic showing various Mes Application Engineer job openings in the United States as of May 2026, with employment types broken down into 71% Full Time, and 29% Contract. Highlights an 100% In-person job distribution, with an average salary of $110,698 per year, or $53.2 per hour.

MES Engineer

PharmEng Technology Americas

San Juan, PR • Remote

Contractor

Posted 16 days ago

Job description


PharmEng Technology is seeking an experienced MES Application Engineer for a project in Houston Texas to help drive our solution-based business model and take our designs to the next level. The MES Application Engineer is responsible for supporting activities such as requirements gathering, definition, and application/test/implementation of Manufacturing Execution System (MES) client projects; primarily, but not limited to, the pharmaceutical/biotech industries.


Job Responsibilities:

  • Responsible for execution of protocols for testing and validating electronic batch records.
  • Responsible for testing of MES systems project, which includes infrastructure setup, software installation, recipe development, and System Acceptance Testing (SAT) with users.
  • Working with MES leads, system users and process owners to develop, revise and maintain MES recipes.
  • Responsible for creating and maintaining electronic logbooks and electronic batch records.
  • Responsible for creating and maintaining electronic batch records and configuring production recipes using object libraries.
  • The potential resource should be capable of driving the testing and deployment of Opcenter software solutions, ensuring sufficient automated testing to maintain solution quality.
  • The potential resource must have experience with Electronic Batch Record System Modeling specifically in the Siemens Opcenter platform.
  • Responsible for assisting in designing and deployment of MES systems to replace paper-based or manual systems including batch records, weigh & dispense, warehouse management and material tracking in a pharmaceutical or medical device environment.
  • Actively participate in fit-gap analysis of customer requirements vs. MES system functionality.
  • Provide technical input to help troubleshoot issues during MES usage and support end-users in MES navigation, EBR execution and general system utilization to ensure users become self-sufficient.
  • Practical hands-on experience with Siemens Opcenter is required.
  • The potential resource should have experience in gathering requirements and translating them into a product vision, demonstrating expertise in development and engineering.
  • Experience in application development, testing, and support based on the Software Development Life Cycle (SDLC) methodology is necessary. Demonstrated understanding of key pharmaceutical niche processes, Pharma GxP regulations, and ISA-88/ISA-95 standards is important in this role.

Job Requirements:

  • Bachelor’s Degree in Engineering/Computer Science/Integrated Manufacturing disciplines or equivalent experience.
  • Firm understanding of cGMP validation requirements/guidelines and current industry practice.
  • More than 4 years of working experience with JAVA, Oracle, C, C++and SQL.
  • More than 4 years of working experience with SAP and ERP.
  • More than 4 years of working experience with Werum PAS-X, Syncade, and Aspen Tech.