Merck Merck Jobs in Philadelphia, PA (NOW HIRING)

We are seeking an Engineer I to support laboratory and bioprocessing activities focused on downstream purification of large, complex molecules. This role is ideal for someone with a strong scientific foundation who is comfortable working in a laboratory environment and has an understanding of bioprocess purification, scaling principles, and wet chemistry techniques. The successful candidate will contribute to laboratory-scale process characterization, troubleshooting, data interpretation, and technical documentation while collaborating closely with cross-functional teams.

Responsibilities:

• Support laboratory activities related to downstream bioprocess purification of large, complex molecules.
• Perform wet chemistry laboratory techniques including pipetting, buffer preparation, filtration, dilution, and stoichiometric calculations.
• Apply scientific understanding of purification operations and bioprocess scaling principles to laboratory activities and process development.
• Conduct laboratory-scale process characterization studies and support experimental activities.
• Operate and work with analytical laboratory instrumentation such as plate readers, densitometers, thermocyclers, cIEF, UV/Vis spectrophotometers, and HPLC/UPLC systems.
• Troubleshoot experimental and equipment-related technical issues and assist in identifying effective solutions.
• Support method development and method transfer activities as needed.
• Maintain accurate laboratory records, including laboratory notebooks, chemical inventories, and data management documentation.
• Interpret, analyze, and present scientific and technical data to support project objectives and decision-making.
• Collaborate effectively with team members and cross-functional partners while maintaining a strong focus on laboratory safety, quality, and scientific rigor.

Education:

• Bachelor's degree in Science, Engineering, or a related scientific/technical field is strongly preferred.

Experience:

• Comfortable working in a laboratory environment.
• Understanding of downstream bioprocess purification processes.
• Scientific understanding of purification operations involving large, complex molecules.
• Technical understanding of bioprocess scaling principles.
• Demonstrated wet chemistry laboratory skills, including pipetting, buffer preparation, filtration, dilution, and stoichiometry.
• Strong technical writing skills and experience maintaining laboratory records and scientific documentation.
• Strong technical problem-solving, data interpretation, and presentation skills.
• Excellent collaboration and team-working abilities.

Preferred Experience:

• Experience working with adjuvant and/or LNP processing.
• Experience with tangential flow filtration (TFF), including microfiltration and ultrafiltration.
• Experience with analytical instrumentation, including plate readers, densitometers, thermocyclers, cIEF, UV/Vis spectrophotometers, and HPLC/UPLC systems.
• Experience supporting laboratory operations.
• Experience working in an industry environment.
• Experience conducting laboratory-scale process characterization studies.
• Experience troubleshooting experimental and equipment-related technical issues.
• Experience with method development and method transfer.
• Experience working in GMP and/or GLP environments.

Additional Information:

• This position requires hands-on laboratory work and the ability to work effectively in a collaborative, technical environment.
• Candidates should demonstrate strong scientific curiosity, attention to detail, and the ability to communicate technical information clearly.

Merck Sharp & Dohme Corp. ("Merck") is a leading research-driven pharmaceutical products and services company. Merck discovers, develops, manufactures, and markets a broad range of innovative products to improve human health, directly and through its joint ventures

Imagine getting up in the morning for a job as important as saving and improving lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery or scientific genius to work in collaboration with other like-minded colleagues to pursue and bring hope to countless people who are battling the most challenging diseases of our time. Our team is always evolving, so if you are among the intellectually curious, join us—and start making your impact today.