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Manager Statistical Programming Jobs in Littleton, MA

Rhythm Pharmaceuticals

Statistical Programmer

Boston, MA · On-site

$110K - $165K/yr

... programming representative, partnering closely with Biostatistics, Data Management, Clinical ... Provide input into protocols, statistical analysis plans, CRF design and annotation, edit checks ...

LivaNova

Statistical Programmer II

Boston, MA · On-site

$90K - $100K/yr

Collaborate with Statistics, Data Management, Clinical, and vendor teams to clarify requirements and resolve data or programming issues. * Develop, validate, and maintain SAS programs in accordance ...

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All JobsStatistical Programming JobsManager Statistical Programming JobsManager Statistical Programming Jobs in Littleton, MA

Manager Statistical Programming information

See Littleton, MA salary details

$87.4K

$152.4K

$257.7K

How much do manager statistical programming jobs pay per year?

As of Sep 2, 2026, the average yearly pay for manager statistical programming in Littleton, MA is $152,432.00, according to ZipRecruiter salary data. Most workers in this role earn between $129,400.00 and $165,600.00 per year, depending on experience, location, and employer.

What is a manager statistical programming?

A Manager Statistical Programming oversees a team of statistical programmers who support clinical trials and research by developing, validating, and maintaining statistical programs. They ensure compliance with regulatory requirements, manage project timelines, and collaborate with statisticians, data managers, and other stakeholders. This role requires strong programming skills in SAS or other statistical software, leadership abilities, and expertise in clinical data standards such as CDISC.

What are the typical daily responsibilities of a manager statistical programming?

As a Manager Statistical Programming, your daily responsibilities usually include overseeing a team of statistical programmers, coordinating the development and validation of statistical programs for clinical trial data analysis, and ensuring deliverables meet regulatory and company quality standards. You will often interact with biostatisticians, data managers, and clinical teams to align programming outputs with study goals. Additionally, you may review project timelines, allocate resources, mentor junior programmers, and contribute to process improvement initiatives. This multifaceted role requires balancing technical oversight with leadership and interdepartmental communication.

What are the key skills and qualifications needed to thrive in the manager statistical programming position, and why are they important?

To excel as a Manager Statistical Programming, you need a solid background in statistics, programming (such as SAS, R, or Python), and experience with clinical trial data management, often supported by a degree in statistics, mathematics, or a related field. Familiarity with regulatory guidelines (e.g., FDA, ICH), data standards such as CDISC, and certifications in relevant programming languages or clinical data processes are highly beneficial. Strong leadership, project management, and effective communication skills are essential for guiding teams and collaborating with cross-functional departments. These skills enable the manager to deliver high-quality statistical programming deliverables, ensure regulatory compliance, and drive team performance in a deadline-driven environment.

What cities near Littleton, MA are hiring for Manager Statistical Programming jobs?

Cities near Littleton, MA with the most Manager Statistical Programming job openings:

Manager Statistical Programming jobs near you
Infographic showing various Manager Statistical Programming job openings in Littleton, MA as of August 2026, with employment types broken down into 80% Full Time, 18% Part Time, and 2% Contract. Highlights an 87% Physical, 2% Hybrid, and 11% Remote job distribution, with an average salary of $152,432 per year, or $73.3 per hour.

Principal Programmer, Statistical Programming (Remote)

Vertex Pharmaceuticals

Boston, MA • On-site, Remote

$149K - $223K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 8 days ago

Vertex Pharmaceuticals rating

6.5

Company rating: 6.5 out of 10

Based on 5 frontline employees who took The Breakroom Quiz

78th of 86 rated pharmaceutical

Job description

Job Description
General Summary:
The Principal Statistical Programmer works with management to delegate tasks appropriately, track progress, and provide expert technical support to team members. In addition, the Principal Statistical Programmer is a designated member of clinical sub-team(s) in the role of project lead Statistical Programmer.
Key Duties and Responsibilities:
  • Works regularly with advanced features of SAS (including interfacing ability with other software applications and operating system tools)
  • Performs quality control checks of SAS code and output produced by other Statistical Programmers to ensure accuracy and consistency within group
  • Demonstrates in-depth knowledge of clinical development and medical data
  • Solves complex clinical trial reporting problems and demonstrates technical proficiency and exercises judgment in supporting daily operations and ensuring that study tasks are completed accurately and in a timely manner
  • Engages with a variety of other functions, including Statistical Programmers, Biostatisticians, Data Management, and other departments engaged in providing data and submission-related activities, often at Senior Management levels
  • Creates all files, documents, and analyses necessary to support an electronic submission in eCTD format, including ISS/ISE
  • Provides leadership to ensure compliance with Vertex SOP'S and FDA/ICH/GCP regulations
  • Provides technical and project management skills to create, review, and approve documentation required to support data analysis, reporting, and CDlSC data submission
  • Participates in project management cross-functional teams that work on standard operating procedures, guidelines, process improvements, system validation and acquisition, customization, and integration of new tools and technologies

Knowledge and Skills:
  • Proficiency in all SAS language, procedures, and functions commonly used in clinical trial reporting including the Macro language, BASE SAS, SAS/STAT and SAS/GRAPH
  • Intermediate knowledge of CDISC Standards
  • Intermediate knowledge of clinical trials
  • Regulatory submission experiences
  • Effective communication (written and verbal) skills to explain difficult information

Education and Experience:
  • Bachelors degree in a Scientific Discipline
  • Typically requires 5+ for M.S. or above and 8+ years for B.S. years of work experience in Biotech, Pharmaceuticals or Clinical Research Organization

Pay Range 136,960.00 - 205,440.00 USD annually
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
#LI-AR1
#LI-Remote
Pay Range:
$149,200 - $223,800
Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation:
Remote-Eligible
Flex Eligibility Status:
In this Remote-Eligible role, you can choose to be designated as:
1. Remote: work remotely five days per week and come into the office on occasion - you're always welcome on-site; or select
2. Hybrid: work remotely up to two days per week; or select
3. On-Site: work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.
#LI-Remote
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

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