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Manager Statistical Programming Jobs in Littleton, MA

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Manager Statistical Programming information

See Littleton, MA salary details

$87.4K

$152.4K

$257.7K

How much do manager statistical programming jobs pay per year?

As of Sep 2, 2026, the average yearly pay for manager statistical programming in Littleton, MA is $152,432.00, according to ZipRecruiter salary data. Most workers in this role earn between $129,400.00 and $165,600.00 per year, depending on experience, location, and employer.

What is a manager statistical programming?

A Manager Statistical Programming oversees a team of statistical programmers who support clinical trials and research by developing, validating, and maintaining statistical programs. They ensure compliance with regulatory requirements, manage project timelines, and collaborate with statisticians, data managers, and other stakeholders. This role requires strong programming skills in SAS or other statistical software, leadership abilities, and expertise in clinical data standards such as CDISC.

What are the typical daily responsibilities of a manager statistical programming?

As a Manager Statistical Programming, your daily responsibilities usually include overseeing a team of statistical programmers, coordinating the development and validation of statistical programs for clinical trial data analysis, and ensuring deliverables meet regulatory and company quality standards. You will often interact with biostatisticians, data managers, and clinical teams to align programming outputs with study goals. Additionally, you may review project timelines, allocate resources, mentor junior programmers, and contribute to process improvement initiatives. This multifaceted role requires balancing technical oversight with leadership and interdepartmental communication.

What are the key skills and qualifications needed to thrive in the manager statistical programming position, and why are they important?

To excel as a Manager Statistical Programming, you need a solid background in statistics, programming (such as SAS, R, or Python), and experience with clinical trial data management, often supported by a degree in statistics, mathematics, or a related field. Familiarity with regulatory guidelines (e.g., FDA, ICH), data standards such as CDISC, and certifications in relevant programming languages or clinical data processes are highly beneficial. Strong leadership, project management, and effective communication skills are essential for guiding teams and collaborating with cross-functional departments. These skills enable the manager to deliver high-quality statistical programming deliverables, ensure regulatory compliance, and drive team performance in a deadline-driven environment.

What cities near Littleton, MA are hiring for Manager Statistical Programming jobs?

Cities near Littleton, MA with the most Manager Statistical Programming job openings:

Manager Statistical Programming jobs near you
Infographic showing various Manager Statistical Programming job openings in Littleton, MA as of August 2026, with employment types broken down into 80% Full Time, 18% Part Time, and 2% Contract. Highlights an 87% Physical, 2% Hybrid, and 11% Remote job distribution, with an average salary of $152,432 per year, or $73.3 per hour.

Manager, Statistical Programming

Rhythm Pharmaceuticals

Boston, MA • On-site

Full-time

Re-posted 3 days ago

Job description

Company Overview
Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the lives of patients living with rare neuroendocrine diseases. We develop medicines for previously untreatable or undertreated diseases. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together.
Opportunity Overview
Rhythm is seeking a Manager, Statistical Programming to join our Biostatistics and Statistical Programming team. This role will provide statistical programming hands-on support across clinical studies, regulatory submissions, and cross-functional development activities. The successful candidate will be responsible for delivering high-quality, compliant analysis datasets, tables, listings, and figures; contributing to study-level and integrated submission deliverables; and partnering closely with Biostatistics, Data Management, Clinical Development, Medical Writing, Regulatory, and external vendors. Depending on level, the role may also include broader responsibility for study oversight, process improvement, standards development, vendor oversight, and mentoring programmers. The level will be determined based on the candidate’s experience, technical depth, and leadership capabilities.
Responsibilities and Duties
  • Lead or support statistical programming activities for assigned clinical studies, including development, validation, and quality control of analysis datasets, tables, listings, and figures for study reports, regulatory submissions, and internal decision-making.
  • Serve as a study lead programmer or programming representative, partnering closely with Biostatistics, Data Management, Clinical Development, Medical Writing, Regulatory, and external vendors to deliver high-quality results on time.
  • Develop, review, and maintain ADaM specifications, TLF shells, programming documentation, reusable macros, and study-level programming standards in alignment with company procedures and regulatory expectations.
  • Provide input into protocols, statistical analysis plans, CRF design and annotation, edit checks, SDTM specifications, integrated data review, and submission strategy to ensure traceability, consistency, and efficient downstream analysis.
  • Support regulatory submission readiness, including preparation and review of define.xml, reviewer guides, submission-ready datasets, and related documentation in compliance with CDISC and global regulatory requirements.
  • Identify programming risks, drive issue resolution, and recommend process improvements that enhance quality, scalability, efficiency, and inspection readiness across studies and programs.
  • Depending on level, mentor junior programmers, provide technical guidance, contribute to resource planning, oversee vendor deliverables, and help shape departmental standards, tools, and best practices.

Qualifications and Skills
  • MS or equivalent degree in Statistics, Biostatistics, Mathematics, Computer Science, or a related discipline; advanced degree preferred.
  • 5+ years relevant statistical programming experience in biotech, pharma, or CRO settings; vendor oversight experience preferred but not required.
  • Strong hands-on expertise in SAS programming, including Base SAS, SAS/STAT, SAS/GRAPH, SAS/SQL, SAS/ODS, and macro development; experience with R or other modern programming tools is a plus.
  • Deep knowledge of CDISC standards, including SDTM, ADaM, define.xml, reviewer guides, and electronic submission requirements in eCTD format.
  • Experience supporting study-level and integrated analyses, including ISS/ISE or other cross-study deliverables, with strong understanding of clinical trial reporting and regulatory submission processes.
  • Able to work independently, manage priorities, collaborate cross-functionally, and deliver high-quality work in a fast-paced environment.
  • For manager-level candidates, experience mentoring programmers, overseeing external vendors, and contributing to resource planning or process improvement is a plus.

This role is based out of our corporate office in Boston, Massachusetts. Rhythm operates in a hybrid-work model. Candidates applying must be willing and able to be in the Boston office in coordination with their department and business needs. This role may involve some travel.
The expected salary range for this position is $110,000 - $165,000. Actual pay will be determined based on experience, level, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and company performance. This role may be eligible for benefits and other compensation such as restricted stock units.
More about Rhythm
We are a dynamic and growing global team spanning more than a dozen countries. At Rhythm we are dedicated to transforming the lives of patients living with rare neuroendocrine diseases by rapidly advancing care and precision medicines that address the root cause.  Our team is passionate about expanding access to reach more patients and developing novel therapies for other rare neuroendocrine diseases, including congenital hyperinsulinism.
 
At Rhythm our core values are:
  • We are committed to advancing scientific understanding to improve patients’ lives
  • We are inspired to tackle tough challenges and have the courage to ask bold questions
  • We are eager to learn and adapt
  • We believe collaboration and ownership are foundational for our success
  • We value the unique contribution each individual brings to furthering our mission

Inherent in our core values is the commitment to act ethically and with integrity in all we do.
Rhythm is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service, or any other class protected by state or federal law. 
Headquartered in Boston, Rhythm is proud to have been named one of the Top Places to Work in Massachusetts.

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