Director, Medicinal Chemistry
$163K - $257K/yr
At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to ... We are seeking a hands-on medicinal chemistry leader with direct experience advancing molecular ...
$163K - $257K/yr
At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to ... We are seeking a hands-on medicinal chemistry leader with direct experience advancing molecular ...
$163K - $257K/yr
At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to ... We are seeking a hands-on medicinal chemistry leader with direct experience advancing molecular ...
Louisville, CO · On-site
$163K - $257K/yr
At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to ... We are seeking a hands-on medicinal chemistry leader with direct experience advancing molecular ...
Louisville, CO · On-site
$163K - $257K/yr
At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to ... We are seeking a hands-on medicinal chemistry leader with direct experience advancing molecular ...
At Lilly, we unite caring with discovery to make life better for people around the world. We are a ... Position Summary The Director/Senior Director, Analytical Methods will serve as a domain expert and ...
At Lilly, we unite caring with discovery to make life better for people around the world. We are a ... Position Summary The Director/Senior Director, Analytical Methods will serve as a domain expert and ...
At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to ... Self-directed and able to work alone in the field effectively managing multiple priorities and ...
At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to ... Self-directed and able to work alone in the field effectively managing multiple priorities and ...
At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to ... Self-directed and able to work alone in the field effectively managing multiple priorities and ...
At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to ... Self-directed and able to work alone in the field effectively managing multiple priorities and ...
| Aspect | Lilly Direct | Lilly Customer Service Representative |
|---|---|---|
| Primary Role | Direct sales and customer engagement for Lilly products | Handling customer inquiries and support for Lilly products |
| Required Credentials | Sales certifications, knowledge of pharmaceutical products | Customer service training, communication skills |
| Work Environment | Field sales, client meetings, healthcare settings | Call centers, office-based support |
| Employer & Industry Usage | Pharmaceutical sales teams at Lilly | Customer support teams at Lilly |
While both roles involve interaction with Lilly products, Lilly Direct focuses on sales and direct customer engagement, often in the field, whereas Lilly Customer Service Representatives primarily handle inquiries and support via phone or online channels. Understanding these differences helps job seekers identify the right position based on their skills and career goals.

$163K - $257K/yr
Full-time
Medical, Dental, Vision, Life, Retirement, PTO
Posted 6 days ago
8.8
Based on 63 frontline employees who took The Breakroom Quiz
11th of 86 rated pharmaceutical
At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work-but it's work worth doing. If you're driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.
Overview
Lilly's Early Molecule Discovery team drives small-molecule hit identification and hit-to-lead progression through structure-based, mechanism-informed, and data-driven design.
We are seeking a hands-on medicinal chemistry leader with direct experience advancing molecular glue programs, from hit finding through candidateselection.
The role requires close collaboration across pharmacology, structural biology, computational chemistry, and DMPK to translate mechanistic hypotheses into optimized molecules.
Success requires both deep bench-level chemistryexpertiseandthe interpersonaland cross-functional leadership skills to guide internal and external teams.
Responsibilities
Lead hit-to-lead optimization of screening hits, improving potency, selectivity, physicochemical properties, and ADMET.
Apply structure-based and data-driven design, incorporating ternary complex structural datawhere relevant.
Design and synthesize novel molecules to test mechanistic hypotheses, includingcooperativity-driven SAR for molecular glue chemotypes.
Design and implement screening cascades tailored to molecular glue pharmacology.
Direct internal and external medicinal chemistry resources, including CRO relationships, to keep programs aligned with strategy and timelines.
Oversee high-throughput synthesis, route scouting, and scale-up to enable efficient compound delivery.
Maintain a strong safety culture and efficient lab operations.
Basic Qualifications
PhD in Organic Chemistry or related Chemistry field with 8+ years of relevant experience in small molecule drug discovery; MS with 10+ years; or BS with 12+ years.
Preferred Skills and Experience
Extensive experience in medicinal chemistry, SAR analysis, and structure- and mechanism-based molecular design.
Direct experience designing oroptimizingmolecular gluedegraders, including protein-protein interface engagement, E3 ligase biology, andneosubstrateidentification.
Demonstrated leadership as a chemistry lead on programs of any mechanism-ideally including a molecular glue program-that reached candidateselection.
Track recordof scientific contributions through publications, patents, or external presentations.
Experience managing or collaborating with external chemistry teams and CROs.
Experience with novel modalities, such as targeted protein degradation and covalent chemistry, and biophysical techniquesto mechanistically understand molecular glue SAR.
Familiarity with computational drug design tools (e.g.,LiveDesign, MOE, Maestro) and AI-enabled chemistry tools.
Self-driven, with a growth mindset and adaptability to fast-evolving science.
Strong communicationand collaboration skills in multidisciplinary, matrixed environments.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women's Initiative for Leading at Lilly (WILL).
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$163,500 - $257,400Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
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Eli Lilly, based in Indianapolis, IN, US, is one of the pioneers in the pharmaceutical industry with a rich history dating back to 1876. This global pharmaceutical company focuses on discovering, developing, manufacturing and selling pharmaceutical products in approximately 120 countries. The company's product categories include endocrinology, oncology, cardiovascular, neuroscience, and immunology. Having invested over $9 billion in research and development in the past decade, Eli Lilly is also committed to creating high-quality medicines that meet real needs. As a recipient of several awards and recognitions, Eli Lilly is known for its focus on life-saving research and drug development. Their mission is to make medicines that help people live longer, healthier, and more active lives.
Pharmaceutical product wholesalers
10,000+ Employees
Indianapolis, IN, US
1876