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It Infrastructure Operations Manager Jobs in Massachusetts

USM

IT Infrastructure Manager

Boston, MA

Operation Management Oversee all aspects of the SOC's IT Department operations responsible for IT infrastructure, Communication (LAN, WAN, email, etc.), database, backup recovery, regulatory ...

Pegasystems

Principal IT Project Manager

Waltham, MA · On-site

$113.80 - $176.50/hr

You'll work with a diverse team of stakeholders from IT Infrastructure, Operations, Security ... Provide project management oversight for complex IT Infrastructure initiatives, including ...

New

ElevateBio

Infrastructure Operations Engineer

Waltham, MA · On-site

$116K - $152K/yr

Requirements: 5+ years of hands-on experience in an IT / infrastructure operations role - Senior Systems Administrator, Network Engineer, Infrastructure Engineer, or IT Manager / Infrastructure Lead ...

ElevateBio

Infrastructure Operations Engineer

Waltham, MA

$116K - $152K/yr

Requirements: 5+ years of hands-on experience in an IT / infrastructure operations role - Senior Systems Administrator, Network Engineer, Infrastructure Engineer, or IT Manager / Infrastructure Lead ...

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It Infrastructure Operations Manager information

What are the key skills and qualifications needed to thrive as an IT Infrastructure Operations Manager?

To thrive as an IT Infrastructure Operations Manager, you need a solid background in IT systems administration, network management, and infrastructure planning, usually supported by a bachelor's degree in computer science or a related field. Familiarity with tools like VMware, Microsoft Azure, ITIL frameworks, and relevant certifications such as CompTIA Network+ or Cisco CCNA are commonly required. Strong leadership, problem-solving skills, and effective communication are essential soft skills for managing teams and collaborating with stakeholders. These skills ensure efficient and secure IT operations, minimize downtime, and support organizational goals.

What is the difference between It Infrastructure Operations Manager vs Network Administrator?

AspectIt Infrastructure Operations ManagerNetwork Administrator
Primary FocusOversees entire IT infrastructure, including servers, storage, and network systemsManages and maintains computer networks, including LAN, WAN, and network hardware
CertificationsITIL, CompTIA Network+, Cisco CCNA, VMwareCompTIA Network+, Cisco CCNA, Cisco CCNP
Work EnvironmentIT departments, data centers, enterprise environmentsCorporate offices, data centers, network operation centers
ResponsibilitiesInfrastructure planning, system deployment, performance monitoring, securityNetwork setup, troubleshooting, security, and performance optimization

The It Infrastructure Operations Manager has a broader scope, overseeing all aspects of IT infrastructure, while the Network Administrator focuses specifically on network systems. Both roles require similar certifications and work environments but differ in responsibilities and scope.

What are some common challenges faced by an IT Infrastructure Operations Manager, and how can they be addressed?

As an IT Infrastructure Operations Manager, you'll often encounter challenges such as managing complex, legacy systems alongside newer technologies, ensuring high system availability, and responding quickly to incidents. Balancing ongoing maintenance with strategic upgrades can be demanding, especially when coordinating with cross-functional teams. Proactive communication, robust documentation, and the adoption of IT service management frameworks like ITIL can help streamline operations and minimize disruptions. Staying current with industry trends and fostering a culture of continuous improvement are also key to overcoming these challenges.

What does an IT Infrastructure Operations Manager do?

An IT Infrastructure Operations Manager is responsible for overseeing the daily operations and maintenance of an organization's IT infrastructure, including servers, networks, and data centers. They ensure all systems run efficiently, securely, and reliably, while managing a team of IT professionals. Their duties often include implementing best practices, troubleshooting issues, planning for upgrades, and coordinating with other departments to meet the company's technology needs.
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What job categories do people searching It Infrastructure Operations Manager jobs in Massachusetts look for? The top searched job categories for It Infrastructure Operations Manager jobs in Massachusetts are:
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It Infrastructure Operations Manager jobs near you
Infographic showing various It Infrastructure Operations Manager job openings in Massachusetts as of August 2026, with employment types broken down into 82% Full Time, 14% Part Time, 1% Temporary, and 3% Contract. Highlights an 94% Physical, 2% Hybrid, and 4% Remote job distribution.

Manager, IT Infrastructure & Operations

Amylyx Pharmaceuticals

Cambridge, MA • On-site

$129K - $145K/yr

Full-time

Posted 14 days ago

Job description

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).
Our mission is powered by our people. Our core values - be audacious, be curious, be authentic, be engaged, and be accountable - creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine's toughest problems, we encourage you to read the opportunity below and apply.
The Opportunity
Amylyx is seeking an experienced IT professional to support our growing organization. This role requires strong technical expertise, a customer-focused mindset, and the ability to serve as the primary point of contact for IT escalations and resolutions. As a key representative of the IT team, this individual will provide responsive, high-quality support to employees across the organization.
Responsibilities
  • Provide responsive IT support to all users and resolve escalated issues.
  • Deliver first- and second-level support through in-person, phone, and remote channels; document issues, resolutions, and service requests in the Service Management system.
  • Serve as the escalation point for external support partners on technical issues.
  • Coordinate scheduled and ad hoc software, system, and infrastructure deployments during business and non-standard hours.
  • Manage and optimize core ITIL service operations, including incident, event, request, problem, and access management.
  • Partner with Amylyx departments to deliver a consistent, high-quality user experience.
  • Support desktop imaging, applications, system administration, configuration, and supplier management, including hosted solutions.
  • Train employees and contractors on IT policies, procedures, and support practices.
  • Develop and maintain clear documentation for IT operational processes.
  • Configure, validate, and implement IT systems and services.
  • Administer SharePoint Online sites, permissions, libraries, governance standards, and user support to enable secure and effective collaboration.
  • Serve as the primary onsite, in-office IT support resource for local technology needs, including conference room systems and equipment.

Required Qualifications
  • Bachelor's degree with 5+ years of experience, or 8+ years of experience in customer-facing technical support or a similar role.
  • 3+ years of experience in a pharmaceutical, biotech, or clinical research environment supporting clinical trials.
  • Demonstrated knowledge of Azure/Entra ID and Office 365.
  • Experience managing cloud infrastructure for a distributed workforce.
  • Knowledge of office and laboratory applications, hardware, and equipment.
  • Strong technical background supporting Windows, macOS, iOS, iPadOS, and cloud applications.
  • Experience supporting telephony and mobile technologies, including Android and iOS.
  • Exceptional organizational skills with the ability to manage multiple priorities and maintain strong attention to detail.
  • Collaborative team player with strong communication and problem-solving skills.
  • Highly motivated and adaptable, with strong interpersonal and leadership skills.
  • Willing and able to provide global on-call support for employees.
  • Ability to work onsite in Cambridge, MA

Work Location and Conditions
  • You will be expected to be onsite at our corporate location in Cambridge, MA three times per week.
  • When working remote, you must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.).

Compensation
The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate's experience, skills, and qualifications, as well as considerations of internal equity.
Estimated Pay Range
$129,000-$145,000 USD
To stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn.
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Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx's management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know.
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

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