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Shape the Future of Oral Drug Development with AI-Driven Predictive Science
Last day to apply: June 30th
Pfizer Research & Development is seeking a highly motivated Postdoctoral Scientist with deep expertise in Artificial Intelligence (AI) and Machine Learning (ML) to advance the prediction of oral drug absorption and formulation performance. In this role, you will play a critical part in developing next-generation predictive models that help transform how drug products are designed, optimized, and translated into clinical success.
You will focus on building, evaluating, and interpreting advanced machine learning models using large, diverse datasets drawn from multiple scientific and clinical sources. Your work will emphasize scalability, interpretability, and real-world applicability ensuring that model outputs are not only technically robust but also scientifically meaningful and decision relevant. A key aspect of this role is the development of explainable modeling approaches, including physics-informed and mechanism-informed learning, to bridge data-driven insights with fundamental pharmaceutical science.
Through this work, you will directly contribute to enabling earlier, faster, and more confident decision-making across Pfizer's R&D portfolio. Your models will help inform formulation strategies, predict in vivo performance, and reduce uncertainty in the development process, ultimately accelerating the delivery of high-quality medicines to patients.
This position is embedded within the Drug Product Design and Supply (DPDS) organization, part of Pfizer's broader Pharmaceutical Sciences division. The role is based in Groton, Connecticut, or Cambridge, Massachusetts, and offers a highly collaborative environment where you will partner closely with interdisciplinary experts across Digital & AI, Clinical Pharmacology, Pharmacometrics, and other quantitative R&D teams. Together, you will integrate cutting-edge AI methodologies with deep domain expertise to solve complex challenges at the intersection of data science and drug development.
Key Responsibilities

• Design, train, and evaluate machine-learning models for predicting oral drug absorption-related outcomes from high-dimensional datasets.
• Develop end-to-end ML pipelines, including data ingestion, feature engineering, model training, validation, and performance benchmarking.
• Work with large, diverse datasets, including experimental biopharmaceutics data and clinical pharmacokinetic datasets, and internally generated datasets relevant to predictive modelling.
• Apply and compare a range of ML approaches, including tree-based methods, neural networks, surrogate models, probabilistic approaches for uncertainty-aware prediction.
• Focus on model interpretability and explainability, linking learned patterns to scientifically meaningful drivers where possible.
• Quantify model robustness, generalizability, and uncertainty, particularly in data-sparse or extrapolative scenarios.
• Translate ML outputs into actionable insights for drug development teams, rather than purely academic metrics.
• Communicate results through internal technical reports, cross-functional presentations, and peer-reviewed publications.
• Contribute to the establishment of AI-enabled predictive platforms within Pfizer R&D.

REQUIRED QUALIFICATIONS (must have)

• PhD in Machine Learning, Data Science, Applied Mathematics, Computational Sciences, Engineering, Pharmaceutical Sciences, or a closely related quantitative discipline.
• Provide two letters of recommendation with your application (e.g. professors/PI).
• Willingness to commit to the fixed-term full-time postdoctoral fellowship (duration: 2-4 years).
• Less than 2 years post-doctoral experience.
• At least 1 first-author scientific research article in high-quality specialty or general readership journals.
• Strong foundation in machine learning and statistical modelling, with hands-on experience building and evaluating predictive models.
• Proficiency in Python and/or R for data analysis and ML development (e.g. scikit-learn, PyTorch, TensorFlow, or similar).
• Experience working with large, heterogeneous datasets and structured scientific data.
• Demonstrated research productivity, evidenced by peer-reviewed publications or equivalent scientific outputs.
• Ability to collaborate effectively in multidisciplinary research environments.

Preferred Qualifications (nice to have)

• Experience applying ML to scientific, pharmaceutical or biomedical, datasets.
• Familiarity with model interpretability, explainable AI, or uncertainty quantification.
• Exposure to mechanistic modelling, including physiologically based pharmacokinetic (PBPK) and physiologically based biopharmaceutics modeling (PBBM), simulation-derived data, or physics-informed / mechanism-informed learning.
• Interest in translating ML models into real-world decision-support tools, rather than purely predictive benchmarks.
• Strong scientific presentation skills.

Training & Development
This position is part of the Pfizer Research & Development Postdoctoral Training Program and offers:

• Mentorship from senior scientists in quantitative drug development.
• Exposure to real R&D decision-making at scale.
• Opportunities for publication, and cross-site collaboration.
• Structured professional development within a world-class pharmaceutical research environment.

PHYSICAL/MENTAL REQUIREMENTS
Ability to perform complex data analysis
Ability to perform mathematical calculations
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

• Will be required to occasionally travel (0-5%)
• Relocation support is available
• Last day to apply: June 30th

The annual base salary for this position ranges from $64,600.00 to $107,600.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.This role is posted in multiple locations. If you are applying for the role in an secondary job posting location where pay transparency regulations apply, your Talent Advisor will share the local pay information with you during the first interview.
Relocation assistance may be available based on business needs and/or eligibility.
Candidates must be authorized to be employed in the U.S. by any employer.
U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.
Sunshine Act
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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Research and Development