Instrument Software Engineer Jobs (NOW HIRING)

What if the work you did every day could impact the lives of people you know? Or all of humanity?
At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.
Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.
Join Illumina's Instrument Software Technical Product Management team and play a pivotal role in shaping the future of our next-generation instruments. You will drive the design and development of the software that powers Illumina's instrument platforms - enabling breakthroughs in genomics, healthcare, and beyond.
As a Senior Software Technical Product Manager, you will own the software product lifecycle for Illumina's instruments. Partnering with customers, field teams, and internal stakeholders, you will translate user workflows and operational needs into clear system requirements that guide development. You will serve as the subject-matter expert and technical voice of the customer for instrument software, collaborating closely with system architects, embedded software/firmware engineers, and test teams to deliver world-class instrument platforms that advance the power of genomics.
Responsibilities

• Own instrument software across its full lifecycle - from product definition and detailed requirements through implementation, production release, and end of life - ensuring alignment with Illumina's instrument platform strategy.
• Define and drive product roadmaps for instrument software in partnership with Marketing and Product Management, tracking progress against business objectives and platform milestones.
• Serve as the subject-matter expert for your instrument software product, with deep command of its capabilities, underlying components, and how they integrate with the broader instrument system.
• Lead requirements elicitation and system decomposition for instrument platform features, translating system models and user workflows into clear, effective system-level requirements.
• Collaborate with multi-disciplinary engineering teams (software, firmware, hardware, test) to transform user needs into a strong product concept and drive software design decisions - including design improvements for on-market instrument platforms.
• Collaborate with development teams in release planning and backlog prioritization at the component level; plan scope for releases and review feature readiness against instrument platform quality standards.
• Lead use case development, requirements analysis, and review meetings that span instrument software and its interfaces with hardware, consumables, and cloud systems.
• Create wireframes, workflow diagrams, and process-flow visualizations to communicate instrument software architecture and user interactions.
• Write formal, detailed software requirement specifications and design documentation in compliance with Illumina's product development processes.
• Manage requirements priority, change control, and planning for future instrument platform versions in a scalable and sustainable manner.
• Support Voice of Customer (VOC) efforts - develop customer personas across clinical, research, and applied segments and advocate on their behalf to shape instrument experiences that maximize satisfaction.
• Gather competitive and market analysis to define the sequencing instrument landscape and surface actionable product gaps.
• Identify risks and drive mitigation recommendations within your area of responsibility and at critical interfaces between instrument software, firmware, and system-level teams.
• Provide technical expertise in identifying, evaluating, and developing procedures that are cost-effective and meet user and business needs for the instrument platform.

Skills & Experience

• Bachelor's degree or higher in Computer Science, Biomedical Engineering, Bioinformatics, or related discipline.
• 4-7 years of experience in system analysis, design, and integration as a Technical Product Manager, Software Systems Engineer, or Solution Architect - preferably in instrument or embedded systems environments.
• Experience with IoT and connected device architectures, edge computing/containerization technologies, and hardware/firmware/software integration as applied to instrument platforms.
• Familiarity with medical device product development, risk analysis (e.g., FMEA), regulatory compliance (e.g., IEC 62304, FDA guidance), and cybersecurity frameworks, with the ability to identify risks and recommend mitigations.
• Knowledge of formalized requirements engineering methods and tools, including traceability across system, software, and test levels.
• Demonstrated ability to exercise independent judgment to define project scope and objectives and to plan across multiple concurrent instrument development efforts with minimal guidance.
• Strong written and verbal communication and presentation skills for both technical and non-technical audiences, including presentations to Senior Management.
• Ability to synthesize complex technical and operational information from cross-functional stakeholders and distill it into coherent system plans and designs that produce user-centric instrument software solutions.
• Experience with enterprise process management tools (Jama, Jira, Confluence) and prototyping/visualization tools (e.g., Balsamiq, Axure, Figma) desired.

#LI-HYBRID
The estimated base salary range for the Senior Software Technical Product Manager role based in the United States of America is: $118,200 - $177,200. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. The range reflects long-term growth in the role; therefore, most candidates are hired between the minimum and middle of the range. Placement depends on experience, skills, location, and internal equity. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work, including access to genomics sequencing, family planning, health/dental/vision, retirement benefits, and paid time off.
We are a company deeply rooted in belonging, promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation, Illumina has always prioritized openness, collaboration, and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, state, and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process, please contact accommodations@illumina.com. To learn more, visit: https://www.dol.gov/ofccp/regs/compliance/posters/pdf/eeopost.pdf. The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants. This role is not eligible for visa sponsorship.