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Hts Assay Development Research Scientist Jobs (NOW HIRING)

TechData Service Company LLC

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Assay Development Scientist (349)

Alameda, CA · On-site

$36 - $46/hr

Associate Research Scientist Job ID: 349 Location: Alameda, CA 94502 (In-person) Pay Rate: $36.00 ... research programs toward development candidate nomination. Top Required Skills * HTS Assay ...

Ultimate Staffing

Associate Research Scientist

Oakland, CA · On-site

$42.16/hr

Associate Research Scientist Pay Rate: $42.16/hr. Duration: 12 months Location: Alameda, California ... Thorough knowledge of assay development for HTS applications, designing workflows, managing, and ...

GrapheneDx

Research Scientist, Assay Development

Boston, MA · On-site

$85K - $120K/yr

The Research Scientist in Assay Development will design and execute experiments to functionalize sensors with nucleic acid or antibody probes for biomarker detection, contributing to the development ...

System One

Associate Research Scientist

Alameda, CA · On-site

Associate Research Scientist Location: Alameda, CA Type: Contract Compensation: 40/hr Work Model ... Experience with assay development for HTS applications and designing workflows is required

System One

Associate Research Scientist

Alameda, CA · On-site

Associate Research Scientist Location: Alameda, CA Type: Contract Compensation: 40/hr Work Model ... Experience with assay development for HTS applications and designing workflows is required

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Hts Assay Development Research Scientist information

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$50.5K

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How much do hts assay development research scientist jobs pay per year?

As of Sep 9, 2026, the average yearly pay for hts assay development research scientist in the United States is $130,117.00, according to ZipRecruiter salary data. Most workers in this role earn between $107,500.00 and $173,000.00 per year, depending on experience, location, and employer.

What is an HTS Assay Development Research Scientist?

HTS Assay Development Research Scientists are professionals who design, develop, and optimize high-throughput screening (HTS) assays for use in drug discovery and biomedical research. Their main role is to create robust and reliable assays that can rapidly test thousands to millions of compounds for biological activity. They work closely with multidisciplinary teams to ensure assays are suitable for automation, data analysis, and scalable screening processes. Their expertise helps to identify promising drug candidates and understand biological mechanisms more efficiently.

What are the key skills and qualifications needed to thrive as an HTS Assay Development Research Scientist?

To thrive as an HTS Assay Development Research Scientist, you need a strong background in biochemistry, molecular biology, or a related field, often supported by a Ph.D. or equivalent research experience. Familiarity with high-throughput screening platforms, liquid handling robotics, and data analysis software such as GraphPad Prism or Spotfire is typically required. Attention to detail, problem-solving skills, and effective teamwork are crucial soft skills in this role. These capabilities ensure robust assay design, reliable data generation, and efficient collaboration for advancing drug discovery projects.

What are some common challenges faced by HTS Assay Development Research Scientists during assay optimization, and how can they be addressed?

HTS Assay Development Research Scientists often encounter challenges such as ensuring assay robustness, minimizing variability, and optimizing signal-to-noise ratios. Troubleshooting may require iterative testing of assay conditions, reagent concentrations, and detection methods. Collaborating with cross-functional teams, such as data analysts and automation engineers, can help address technical hurdles and streamline the transition from development to high-throughput screening. Staying current with advancements in assay technologies and regularly validating controls also contributes to successful assay optimization.

What is the difference between Hts Assay Development Research Scientist vs Hts Laboratory Technician?

AspectHts Assay Development Research ScientistHts Laboratory Technician
Required CredentialsBachelor's or Master's in Life Sciences, PhD often preferredAssociate's or Bachelor's in Life Sciences or related field
Work EnvironmentResearch labs, experimental design, assay developmentLaboratory testing, sample preparation, routine assays
Employer & Industry UsageBiotech, pharmaceutical companies, research institutionsLaboratories within biotech and pharma companies, contract labs

The Hts Assay Development Research Scientist focuses on designing and optimizing assays, requiring advanced education and research skills. In contrast, the Hts Laboratory Technician performs routine lab tasks and sample processing. Both roles are essential in biotech and pharma industries but differ in responsibilities and qualifications.

What cities are hiring for Hts Assay Development Research Scientist jobs?

Cities with the most Hts Assay Development Research Scientist job openings:

What states have the most Hts Assay Development Research Scientist jobs?

States with the most job openings for Hts Assay Development Research Scientist jobs include:

What are popular job titles related to Hts Assay Development Research Scientist jobs?

For Hts Assay Development Research Scientist jobs, the most frequently searched job titles are:

Infographic showing various Hts Assay Development Research Scientist job openings in the United States as of September 2026, with employment types broken down into 1% Internship, 1% As Needed, 82% Full Time, 14% Part Time, and 2% Contract. Highlights an 87% Physical, 2% Hybrid, and 11% Remote job distribution, with an average salary of $130,117 per year, or $62.6 per hour.

Assay Development Scientist (349)

Alameda, CA • On-site

TechData Service Company LLC
Biotechnology Research and Development • 51 - 200 employees
Learn more about TechData Service Company LLCexternal

$36 - $46/hr

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Medical, Dental, Vision

Posted 6 days ago

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Job description

Job Title: Associate Research Scientist

Job ID: 349

Location: Alameda, CA 94502 (In-person)

Pay Rate: $36.00 – $46.00 / hour (W2)

Duration: 12 Months (Extension & potential conversion possible after 1 year)

Shift: 8:00 AM – 5:00 PM PST (With some flexibility)

Interview Process: 1 Round (2-hour onsite panel across ~2 interviews)


Job Summary

The Associate Research Scientist will conceptualize, develop, optimize, and execute biophysical and biochemical assays to support hit identification, validation, and mechanism of action (MoA) studies for early-stage small molecule drug discovery projects. This role involves developing automated High-Throughput Screening (HTS) biochemical assays (1536-well plate) and biophysical assays (96/384-well plate formats) to advance research programs toward development candidate nomination.

Top Required Skills

  1. HTS Assay Development & Screening: High-throughput screening in 1536- and 384-well plate formats.
  2. Biophysical Assays: Surface Plasmon Resonance (SPR) preferred.
  3. Assay Technologies: HTRF, AlphaLISA, MSD, ELISA, Fluorescence Polarization (FP), and Luminescence-based assays.
  4. Lab Automation: Experience with automated screening workflows and liquid handling/dispensing equipment.
  5. Bonus: Cellular assay experience, small molecule heterobifunctional degraders, or molecular glues.

Key Responsibilities

  • Assay Development & Execution: Independently design, optimize, and run biophysical and biochemical assays for small molecule compound profiling and HTS campaigns.
  • Workflow Optimization: Evaluate and implement new technologies, protocols, and automated tools to support projects from hit finding through lead optimization and MoA studies.
  • Cross-Functional Collaboration: Partner with internal teams, present data/project updates to department leadership, and contribute to discovery project meetings.
  • Compliance & Documentation: Maintain accurate electronic lab notebooks according to company IP policies and adhere to all laboratory health and safety standards.

Qualifications & Experience

Education & Professional Experience

  • Bachelor’s Degree in a related discipline + 5+ years of experience, OR
  • Associate’s Degree in a related discipline + 7+ years of experience, OR
  • High School Diploma / GED + 9+ years of experience.

Technical & Soft Skills

  • Small Molecule Drug Discovery: Hands-on experience developing biophysical and biochemical assays for small molecule targets.
  • SPR Expertise: Strong working knowledge of SPR techniques to discover and characterize small molecule-protein target complexes.
  • Automation Familiarity: Experience using liquid handlers, dispensers, plate readers, and automated workflows.
  • Communication & Management: Strong problem-solving, multi-tasking, and written/verbal communication skills; ability to align daily experimental work with broader discovery goals.

Additional Information

  • Supervisory Role: None
  • Work Environment: Primary duties conducted in a laboratory setting
  • Benefits: Health insurance, Dental insurance

Company Description

https://quantive.bio/