The highest paying RN (Registered Nurse) jobs typically include specialized roles such as Nurse Anesthetists (CRNAs), Nurse Practitioners, Nurse Managers, and Clinical Nurse Specialists. These positions often require advanced degrees, certifications, and several years of experience. Factors like location, type of healthcare facility, and shift differentials can also impact RN salaries. In general, RNs who work in metropolitan areas, critical care, or surgical settings tend to earn higher wages compared to those in other nursing roles.