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Alnylam Pharmaceuticals

... will help you to exceed. A strong understanding in US GAAP and internal/external reporting is ... Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a ...

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Vice President, Toxicology

Alnylam Pharmaceuticals

Cambridge, MA • On-site

$310K - $420K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Re-posted 3 days ago

Job description

Overview:
The successful candidate will join an experienced team of toxicologists providing discovery and development support across a strong and diverse pipeline of programs spanning multiple disease areas. In addition to leading and contributing to regulatory toxicology activities, this role will place strong emphasis on supporting research initiatives and providing scientific leadership within the broader Early Development department.
Responsibilities:
  • Lead and oversee a team of toxicologists and technical staff, fostering scientific excellence, collaboration, and professional development.
  • Provide strategic leadership for nonclinical safety assessment programs supporting discovery, development, and regulatory submissions.
  • Collaborate effectively across disciplines, including pathology, DMPK, biology, clinical, regulatory, and pharmacology, ensuring strong cross-functional integration.
  • Engage effectively with regulatory authorities, supporting product defense and contributing to successful regulatory submissions and approvals.
  • Design and implement scientifically robust and strategically aligned nonclinical development programs to support advancement of drug candidates and regulatory filings.
  • Lead and manage nonclinical studies and programs across a portfolio of projects, conducted internally and through CRO partners, either directly or through direct reports.
  • Prepare and critically review scientific and regulatory documents to ensure high quality, clarity of presentation, and sound scientific interpretation.
  • Partner with cross-functional teams to design investigative toxicology studies supporting development candidates and platform technology evaluations.
  • Present key findings and safety strategies to program teams, R&D leadership, and regulatory authorities.
  • Mentor and develop toxicologists and scientists, helping build organizational expertise in pharmaceutical toxicology and nonclinical safety.

Qualifications:
  • PhD in Toxicology, Pathology, or a related scientific discipline.
  • 15+ years of experience in the pharmaceutical or biotechnology industry, with demonstrated expertise and accomplishments in regulatory toxicology.
  • Proven leadership experience managing departments, groups, or teams within a scientific organization.
  • Demonstrated experience preparing and supporting global regulatory submissions and associated documentation.
  • Strong ability to interpret and integrate complex datasets across multiple disciplines, including pharmacology, DMPK, toxicology, and pathology, with a focus on assessing clinical relevance and impact.
  • Proven ability to apply creative and strategic approaches to resolving challenges in predictive toxicology.
  • Strong problem-solving skills, with the ability to remain highly organized and lead effectively in a fast-paced environment with evolving priorities.
  • Excellent interpersonal skills and a demonstrated ability to collaborate across diverse cross-functional teams.
  • Excellent written and verbal communication skills.
  • Strong interest in the therapeutic and scientific areas aligned with Alnylam's research focus.

#LI-KB1 #LI-Onsite
U.S. Pay Range
$310,000.00 - $420,000.00
The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).
Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.
Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers
About Alnylam
We are the leader in RNAi therapeutics - a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.
At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

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