Gene Therapy Project Manager Jobs (NOW HIRING)

Primary Location
Burnet Campus
Department
CBDI Support
Shift
Day (United States of America)
Schedule
Full time
Weekly Hours
40
FTE
1
Employee Status
Regular
*Expected Starting Pay Range
$81,723.20 - $104,208.00
*Starting pay is based on experience, skills, and equity; exceptions may apply for highly qualified candidates. Additional pay (e.g., shift, on-call, or weekend differentials) and benefits may apply. Annual pay may vary based on FTE status.
Registered Nurse Care Manager (Navigator) - Rare Hematology, Gene Therapy & Translational Research
Department/Unit: Cancer & Blood Diseases Institute
Shift/Hours: Days | 40 hours/week | Monday-Friday
Location: Cincinnati Children's Hospital
Coordinate Complex Care. Advance Innovation. Change Children's Lives.
Cincinnati Children's is seeking an experienced Registered Nurse Care Manager (Navigator) to join our highly specialized Rare Hematology, Genetic Hematology, Gene Therapy, and Translational Research programs.
This is an exceptional opportunity for a BSN-prepared nurse who enjoys complex care coordination, multidisciplinary collaboration, patient advocacy, and working at the forefront of innovative pediatric medicine.
Our program is experiencing significant growth, with new patient volumes increasing from 66 patients in FY25 to 137 patients in FY26. As the population and complexity of care continue to expand, this role is essential to ensuring patients and families receive timely, coordinated, and comprehensive care.
About the Role
The RN Care Manager (Navigator) provides specialized support for eight physicians caring for patients with rare inherited bone marrow failure syndromes, genetic hematologic disorders, and other complex conditions.
You will serve as a primary liaison among patients and families, physicians, advanced practice providers, genetic counselors, research teams, financial specialists, and other healthcare professionals. You will coordinate care across the continuum, helping patients navigate complex diagnostic evaluations, genetic testing, specialty consultations, treatment planning, gene therapy, research opportunities, and long-term follow-up.
What You'll Do

• Manage and coordinate care for a complex population of pediatric patients with rare inherited bone marrow failure syndromes, genetic hematologic disorders, and other medically complex conditions.
• Partner with eight physicians and multidisciplinary teams to coordinate comprehensive patient care.
• Serve as a consistent point of contact and advocate for patients and families throughout their healthcare journey.
• Coordinate complex diagnostic evaluations, genetic testing, laboratory studies, specialty consultations, procedures, and treatment plans.
• Coordinate the numerous clinical requirements associated with gene therapy, including specialty consultations, diagnostic testing, stem cell collection, treatment scheduling, and follow-up.
• Support patients receiving or being evaluated for emerging gene therapies, including Casgevy and Lyfgenia, with additional therapies anticipated as the program evolves.
• Coordinate insurance authorizations and financial requirements to help prevent delays in treatment.
• Monitor authorization expiration dates, treatment timelines, testing requirements, and scheduling needs and proactively address potential barriers.
• Coordinate care for patients referred from outside institutions and healthcare organizations, including regional referral partners.
• Facilitate communication between Cincinnati Children's and referring providers to ensure continuity of care.
• Coordinate complex treatment plans for patients requiring therapies such as rituximab, IVIG, and enzyme replacement therapy.
• Provide education to patients and families regarding diagnoses, genetic testing, treatment options, procedures, gene therapy, clinical research, and ongoing care.
• Collaborate with genetic counselors, research teams, financial specialists, social work, pharmacy, laboratory services, and other specialty providers.
• Support translational research, clinical trials, registries, and other innovative programs as appropriate.
• Monitor patients throughout their care journey and ensure recommended evaluations, treatments, and follow-up are completed.
• Identify barriers to care and develop solutions that promote timely access and an exceptional patient and family experience.
• Participate in multidisciplinary meetings and contribute clinical expertise to complex care planning.
• Maintain accurate and timely documentation and communication across the care team.
• Serve as a clinical resource for colleagues and contribute to process improvement initiatives that enhance patient care and program efficiency.

Why This Role Matters
The Rare Hematology, Genetic Hematology, Gene Therapy, and Translational Research programs are rapidly expanding. The increase in patients being evaluated for and receiving gene therapy has created significant additional coordination needs.
Patients pursuing gene therapy may require multiple specialty consultations, extensive laboratory testing, stem cell collection, insurance authorization, financial coordination, and highly time-sensitive scheduling. Treatment plans can require frequent adjustments based on clinical status, authorization timelines, and availability of required services.
The program is also experiencing increased referrals from outside organizations and caring for more medically complex patients requiring coordination of multiple therapies and specialties.
The RN Care Manager (Navigator) is essential to keeping these complex care plans moving forward. By coordinating services, anticipating barriers, communicating across disciplines, and advocating for patients and families, this role helps ensure timely access to care while reducing coordination burden on providers and clinic staff.
What We're Looking For
Required:

• Current Registered Nurse license in the State of Ohio.
• Bachelor of Science in Nursing (BSN).
• Minimum of five years of professional nursing experience.
• Strong clinical judgment and critical-thinking skills.
• Demonstrated experience coordinating care for complex patients.
• Excellent organizational, communication, and problem-solving skills.
• Ability to independently prioritize and manage multiple complex patient needs.
• Ability to effectively collaborate with physicians and multidisciplinary teams.
• Strong patient advocacy and family-centered care skills.

Preferred:

• Pediatric hematology/oncology experience.
• Experience with rare diseases or genetic hematology.
• Experience with bone marrow failure syndromes.
• Experience with gene therapy or cellular therapy.
• Care management, nurse navigation, or nurse coordinator experience.
• Experience coordinating clinical trials or translational research.
• Experience with insurance authorization and financial coordination.
• Experience with stem cell collection or transplantation.
• Certification in pediatric nursing, oncology, care management, or a related specialty.

Why Cincinnati Children's?
At Cincinnati Children's, you will work alongside nationally recognized experts who are advancing treatment for rare and complex pediatric conditions.
This is an opportunity to be part of innovative programs involving gene therapy, translational research, and emerging treatments that have the potential to transform the lives of children and families.
If you are a BSN-prepared nurse with at least five years of experience who enjoys complex care coordination, innovation, clinical problem-solving, multidisciplinary collaboration, and patient advocacy, we invite you to join our team.
At Cincinnati Children's, we come to work with one goal: to make children's health better.
JOB RESPONSIBILITIES

• Evaluation and Outcomes - Evaluate the timeliness and availability of treatments and services and adjusting level of service according to changing needs. Evaluate actual patient outcomes in relation to expected outcomes for the care managed population. Identifies quality improvement opportunities such as consistent issues with smooth care progression and communicates them to the department's management/leadership team, providing supporting data and reference to evidence based practice when possible. Participates in the management of metrics (outcomes, value, and experience) across the continuum of care.
• Monitoring - Monitor the patient's progress in achieving the goals, objectives, and expected outcomes of the plan at specified time frames. Utilizes Critical Pathways and /or Clinical Guidelines to monitor patient progress toward health. Follows through on the status of key diagnostic and treatment tests and procedures to insure continued progression. Interacts with involved departments and other members of the healthcare team to negotiate and expedite scheduling and completion of tests and procedures. Identifies, documents and communicates barriers to the plan of care to the healthcare team. Serves as the contact person for and works collaboratively with the multidisciplinary team to manage resource usage/utilization.
• Coordination - Facilitates communication and coordination between members of the health care team across all phases of care. Involves the patient, family and caregivers in the decision-making process in order to minimize fragmentation in services. Leads the coordination of care, setting priorities and encouraging the appropriate use and timeliness of health care services Facilitates a smooth transition of care by ensuring that key components of the plan of care and/or patient needs are communicated to subsequent care providers across the continuum. Demonstrates an understanding of legal and regulatory issues (HIPPA, EMTALA, regulatory agencies, CMS, legal P&P) impacting the care delivery and reimbursement process. Negotiates and advocates for the patient for services and resources needed. Provides patient/family education regarding post-acute services, community resources, or other needs as identified. Creates an environment to support patient safety by integrating patient safety goals into daily practice based on the patient's age and the population served.
• Implementation - Implementing the agreed upon plan of care. Provides self-management support to high risk/complex patients and families, including helping families identify and overcome barriers to care. Utilizes collaborative communication skills to establish a working partnership with the patient/family/caregiver, treatment team, and community resources/providers. Educates the patient, family and caregiver along with members of the health care delivery team about treatment options. Empowers the patient, family, and caregiver to problem-solve by exploring options of care when available and alternative plans, when necessary, to achieve desired outcomes. Encourages the appropriate use of health care services and strives to improve quality of care and maintain cost effectiveness on a case-by-case basis. Support and facilitate all care transitions from inpatient to outpatient, practice to practice and from pediatric to adult systems of care.
• Planning - Planning with the patient, family or caregiver and providers, to maximize health outcomes and ensure quality, cost effective care. Works with the patient, family and caregiver, to establish treatment goals that meet the patient's healthcare and safety needs. Integrates patient, family and caregiver decisions and choice into the planning process. Coordinates the plan of care and maintains documentation of case updates and discussion/events involving individuals responsible for patient welfare (e.g. family, providers, and care team members). Identifies the need for patient/family team meeting, participates in the meeting and documents the outcomes. Proactively identifies medical and psychosocial services needed by the patient. Reassess plan of care and adjusts plan according to patient needs.

JOB QUALIFICATIONS

• Bachelor's degree in a related field.
• ACEN/CCNE accredited BSN OR MSN OR Associate/Diploma RN AND 2+ years of experience and BSN/MSN.
• 5+ years of work experience in a related job discipline.
• Active Ohio RN License. May be required to obtain other state licensure.

About Us
At Cincinnati Children's, we come to work with one goal: to make children's health better. We believe in a holistic team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better and find energy and inspiration in our shared purpose. If you want to be the best you can be, you can do it at Cincinnati Children's.
Cincinnati Children's is:

• Recognized by U.S. News & World Report as a top 10best Children's Hospitals in the nation for more than 15 years
• Consistently among the top 3 Children's Hospitals for National Institutes of Health (NIH) Funding
• Recognized as one of America's Best Large Employers (2025), America's Best Employers for New Grads (2025)
• One of the nation's America's Most Innovative Companies as noted by Fortune
• Consistently certified as great place to work
• A Leading Disability Employer as noted by the National Organization on Disability
• Magnet® designated for the fourth consecutive time by the American Nurses Credentialing Center (ANCC)

We Embrace Innovation-Together. We believe in empowering our teams with the tools that help us work smarter and care better. That's why we support the responsible use of artificial intelligence. By encouraging innovation, we're creating space for new ideas, better outcomes, and a stronger future-for all of us.
Comprehensive job description provided upon request.
Cincinnati Children's is proud to be an Equal Opportunity Employer comm