Working knowledge of modeling approaches, including PBPK, QSP, and semi-mechanistic PK/PD ... this full-time position for candidates working onsite at our headquarters in Redwood City, CA is ...
Working knowledge of modeling approaches, including PBPK, QSP, and semi-mechanistic PK/PD ... this full-time position for candidates working onsite at our headquarters in Redwood City, CA is ...
Full Time Pbpk Modeling information
What is PBPK modeling and what does a full-time PBPK modeler do?
PBPK modeling stands for Physiologically Based Pharmacokinetic modeling. A full-time PBPK modeler develops mathematical models that simulate the absorption, distribution, metabolism, and excretion of drugs in the body using physiological and biochemical parameters. This work helps predict how drugs behave in different populations, support drug development, and inform regulatory submissions. PBPK modelers often collaborate with pharmacologists, toxicologists, and regulatory scientists to optimize drug dosing and assess safety.
What are the key skills and qualifications needed to thrive as a full time PBPK modeler, and why are they important?
A Full Time PBPK Modeler needs expertise in pharmacokinetics, mathematical modeling, and a background in pharmaceutical sciences or a related field, typically with an advanced degree (MS/PhD). Proficiency in modeling software such as Simcyp, GastroPlus, or PK-Sim, along with familiarity with programming languages like R or MATLAB, is standard. Strong analytical thinking, attention to detail, and effective communication are crucial soft skills for interpreting data and collaborating with interdisciplinary teams. These skills ensure accurate modeling predictions, support drug development decisions, and facilitate regulatory submissions.
What are some common challenges faced by professionals in full time PBPK modeling roles, and how can they be addressed?
Professionals working full-time in PBPK (Physiologically-Based Pharmacokinetic) modeling often encounter challenges such as integrating complex biological data, managing large datasets, and ensuring model accuracy across diverse populations. Navigating evolving regulatory requirements and staying current with software tools can also be demanding. These challenges can be addressed by collaborating closely with interdisciplinary teams, attending relevant training or workshops, and maintaining open communication with regulatory and clinical partners to ensure models are robust and compliant.
What is the difference between Full Time Pbpk Modeling vs Pharmacometric Modeling?
| Aspect | Full Time Pbpk Modeling | Pharmacometric Modeling |
|---|---|---|
| Required Credentials | Advanced degrees in pharmacology, pharmacokinetics, or related fields; often certifications in modeling | Similar credentials; often includes pharmacometrics certifications or advanced degrees |
| Work Environment | Pharmaceutical companies, biotech firms, research institutions; focus on drug absorption, distribution, metabolism, and excretion | Same environments; emphasis on dose-response relationships and clinical trial data analysis |
| Industry Usage | Used for predicting drug behavior in populations, dose optimization, and regulatory submissions | Used for understanding clinical efficacy, safety, and dose adjustments based on patient data |
Full Time Pbpk Modeling and Pharmacometric Modeling share similar credentials and work environments, but differ in focus. Pbpk modeling emphasizes predicting drug behavior in the body using physiologically based models, while pharmacometric modeling concentrates on analyzing clinical data to inform dosing and efficacy.
What is the average salary for a full time PBPK modeling?
The average salary for a full-time PBPK (Physiologically Based Pharmacokinetic) modeler typically ranges from $80,000 to $130,000 annually, depending on experience, education, and location. Professionals with advanced skills in pharmacokinetics, modeling software, and regulatory knowledge tend to earn higher salaries in this specialized field.
What are the most commonly searched types of Pbpk Modeling jobs in California?
The most popular types of Pbpk Modeling jobs in California are:
What are popular job titles related to Full Time Pbpk Modeling jobs in California?
For Full Time Pbpk Modeling jobs in California, the most frequently searched job titles are:
What job categories do people searching Full Time Pbpk Modeling jobs in California look for?
The top searched job categories for Full Time Pbpk Modeling jobs in California are:
What cities in California are hiring for Full Time Pbpk Modeling jobs?
Cities in California with the most Full Time Pbpk Modeling job openings:
Principal Scientist, Cancer Pharmacology, Translational Research
Redwood City, CA • On-site
Revolution Medicines
Full-time
Re-posted 5 days ago
Job description
Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company's RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
The Opportunity:
As a Principal Scientist in the Cancer Pharmacology team within the Translational Research group, in the Biomedical Discovery Research Department, you will:
Required Skills, Experience and Education:
Preferred Skills:
#LI-Hybrid #LI-NE1
The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.
Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.
Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.
Base Pay Salary Range
$190,000-$238,000 USD
We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.
Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address.
If you believe you've been contacted by someone impersonating a Revolution Medicines recruiter, please report it to careers@revmed.com so we can share these impersonations with our IT team for tracking and awareness.
The Opportunity:
As a Principal Scientist in the Cancer Pharmacology team within the Translational Research group, in the Biomedical Discovery Research Department, you will:
- Provide scientific and strategic leadership for RAS(ON) inhibitor programs by translating mechanistic insights in RAS biology into impactful pharmacology strategies and translational study plans.
- Lead, mentor, and develop a high-performing group of in vivo scientists, fostering scientific excellence, innovation, and cross-functional collaboration.
- Drive the design, execution, and interpretation of in vivo efficacy and PK/PD studies conducted internally and through external partners to advance oncology discovery and development programs.
- Partner closely with the cross-functional quantitative modeling group to provide biological insight, translational context, and critical evaluation supporting PK/PD modeling efforts.
- Influence portfolio progression through generation of high-impact data packages and contributions to regulatory submissions.
- Serve as the in vivo pharmacology expert on cross-functional project teams, partnering closely with colleagues in Chemistry, Discovery Biology, DMPK, and Toxicology to build cohesive preclinical data sets.
- Communicate scientific strategy, key findings, and program recommendations to cross-functional teams and senior leadership to drive informed decision making.
Required Skills, Experience and Education:
- Ph.D. in Pharmacology or Cancer Biology, or a related scientific discipline with direct relevance to oncology drug development.
- 5+ years of relevant industry experience in oncology drug discovery and development.
- Demonstrated scientific leadership, strategic thinking, and problem-solving skills in advancing oncology drug discovery programs.
- Deep expertise in tumor biology, RAS signaling pathways, and translational oncology pharmacology.
- Extensive hands-on experience in the design, analysis, and interpretation of in vivo oncology studies and disease models.
- Strong understanding of translational PK/PD concepts and integration of efficacy, biomarker, and pharmacokinetic data to support translational hypotheses.
- Working knowledge of modeling approaches, including PBPK, QSP, and semi-mechanistic PK/PD frameworks.
- Proven track record of leading, mentoring, and developing scientific talent within collaborative, matrixed research environments.
- Excellent written and verbal communication skills with the ability to effectively communicate complex scientific concepts to both specialist and non-specialist audiences.
- Demonstrated track record of scientific innovation, productivity, and collaboration in a dynamic and fast-paced drug discovery environment.
Preferred Skills:
- Experience with RAS-targeted therapies and diverse oncology therapeutic modalities, including small molecules, antibodies, and antibody-drug conjugates (ADCs).
- Strong theoretical understanding of the concepts, assumptions, and limitations associated with PK/PD and translational mathematical modeling.
- Experience contributing to IND-enabling activities and regulatory documentation is desirable.
- Demonstrated ability to influence scientific strategy and effectively operate within highly collaborative cross-functional teams.
#LI-Hybrid #LI-NE1
The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.
Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.
Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.
Base Pay Salary Range
$190,000-$238,000 USD
We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.
Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address.
If you believe you've been contacted by someone impersonating a Revolution Medicines recruiter, please report it to careers@revmed.com so we can share these impersonations with our IT team for tracking and awareness.