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Ex Vivo Jobs (NOW HIRING)

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In Vivo Research Associate

Hummelstown, PA · On-site

Conduct downstream analyses of ex vivo samples to support study objectives. * Assist in the preparation and maintenance of study documentation to ensure compliance with protocols and regulatory ...

Vrtx

Pharmacology Research Scientist

San Diego, CA · On-site

$110K - $166K/yr

Design and execute experiments utilizing ex vivo organ perfusion and nervous system models to evaluate drug efficacy, distribution, safety, and mechanism of action. * Conduct in vitro and in vivo ...

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Ex Vivo information

What are the key skills and qualifications needed to thrive as an Ex Vivo Scientist, and why are they important?

To thrive as an Ex Vivo Scientist, you need a strong background in biology or biomedical sciences, experience with tissue handling, and a relevant degree such as a BSc, MSc, or PhD. Familiarity with laboratory equipment, flow cytometry, cell culture systems, and data analysis software is typically required. Attention to detail, problem-solving, and effective teamwork are essential soft skills for this role. These competencies ensure accurate experimental results, efficient workflow, and meaningful contributions to research and development projects.

What are some common challenges faced by professionals working in ex vivo research roles, and how can they be addressed?

Professionals in ex vivo research often encounter challenges such as maintaining tissue viability outside the organism, ensuring precise experimental conditions, and managing strict timelines for data collection. Collaboration with cross-functional teams, such as pathologists and laboratory technicians, is crucial for troubleshooting technical issues and optimizing protocols. Staying up to date with best practices and technological advancements can also help address these challenges and improve experimental outcomes.

What does an Ex Vivo specialist do?

An Ex Vivo specialist works with biological samples, such as tissues or organs, outside of a living organism to study their functions, responses to treatments, or test new medical techniques. These professionals often support research in areas like drug development, transplantation, or disease modeling. Their responsibilities may include preparing samples, conducting experiments, analyzing data, and maintaining laboratory equipment. Ex Vivo specialists play a key role in advancing scientific knowledge and developing new therapies.
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Ex Vivo jobs near you

Scientist ll - SR Senior Scientist Ex Vivo & 3D Model Assays

WuXi Biologics

Natick, MA

$73K - $117K/yr

Full-time

Posted 17 days ago

Job description

Title: Scientist ll - Senior Scientist Ex Vivo & 3D Model Assays
Location: Natick, MA
Job Summary
We are seeking a highly motivated Scientist with hands-on expertise in ex vivo immune assays, 3D spheroid, and organoid-based platforms to support our preclinical drug discovery efforts. The successful candidate will have a PhD with 2-3 yrs or Master's degree with 5-6 years of relevant industry experience and will play a key role in evaluating the biological activity and mechanism of novel therapeutic candidates across oncology, autoimmune, and inflammatory disease areas.
This role is ideal for a scientist passionate about translating complex biology into meaningful data using patient-relevant assay systems
Job Responsibilities:
  • Design, execute, and analyze ex vivo assays using human PBMCs, tumor digests, or tissue-derived immune cells.
  • Develop and implement 3D spheroid and organoid-based co-culture systems, including tumor-immune or stroma-immune models.
  • Perform high-content immunophenotyping and functional readouts using multi-color flow cytometry, cytokine profiling (MSD, ELISA, Luminex), and live-cell imaging.
  • Support pharmacodynamic, MOA, and efficacy studies for biologics, TCEs, and other immunomodulatory agents.
  • Work with human biospecimens (e.g., tumor tissue, blood, ascites) and maintain compliance with biosafety and sample handling protocols.
  • Maintain detailed records, present findings at team meetings, and contribute to internal documentation and publications.

Qualifications:
  • PhD in Immunology, Cell Biology, Pharmacology, or a related field with 2-3 years of hands-on industry experience, or a Master's degree with 4-5 years of relevant experience in a biotechnology or pharmaceutical setting.
  • Proven expertise in ex vivo immune cell assays, primary cell culture, and immune cell functional analysis.
  • Experience with 3D cell culture systems such as tumor spheroids, organoids, or co-culture models.
  • Strong skills in flow cytometry (data acquisition and analysis), cytokine assays, and viability/proliferation platforms.
  • Familiarity with handling human tissue samples and BSL-2 laboratory practices.
  • Excellent organizational skills, attention to detail, and the ability to independently troubleshoot and optimize assays.
  • Strong team player with effective communication and presentation skills.

Preferred Qualifications:
  • Experience applying 3D culture platforms to immune-oncology, autoimmune disease, or ither disease area.
  • Proficiency in flow cytometry software (e.g., FlowJo), imaging platforms (e.g., Incucyte), and analysis tools (e.g., GraphPad Prism).
  • Knowledge of T cell biology, myeloid interactions, or tumor microenvironment.
  • Familiarity with antibody-based therapeutic formats, including T cell engagers, ADCs or bispecifics.

The anticipated pay range for this position is $73,000 - $117,000
An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability

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