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How much do entry level picc nurse jobs pay per year?

As of Jul 28, 2026, the average yearly pay for entry level picc nurse in the United States is $109,156.00, according to ZipRecruiter salary data. Most workers in this role earn between $80,000.00 and $92,000.00 per year, depending on experience, location, and employer.
What are the most commonly searched types of Picc Nurse jobs? The most popular types of Picc Nurse jobs are:
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Infographic showing various Entry Level Picc Nurse job openings in the United States as of July 2026, with employment types broken down into 87% Full Time, 10% Part Time, 1% Temporary, and 2% Contract. Highlights an 96% Physical, 1% Hybrid, and 3% Remote job distribution, with an average salary of $109,156 per year, or $52.5 per hour.
Registered Nurse - Oncology Cancer Treatment Unit - RN

Registered Nurse - Oncology Cancer Treatment Unit - RN

Mayo Clinic

Rochester, MN • On-site

Full-time

Medical, Dental, Vision, Retirement

Posted 27 days ago

Mayo Clinic rating

7.8

Company rating: 7.8 out of 10

Based on 692 frontline employees who took The Breakroom Quiz

105th of 890 rated healthcare providers

Job description


As a Chemotherapy Infusion RN, you'll do more than deliver treatment. You'll make a lasting impact during some of the most critical moments in a patient's life.
If you've been looking for a role where your work truly matters, this is one of those places.
Why this team feels different
You'll join a team where you are supported, valued, and truly part of something. Leaders are approachable, and teammates show up for one another, because no one does this work alone.
Here, you're encouraged to grow, speak up, and bring your full self to the team.
The work you'll do
In our 53-chair outpatient oncology treatment unit (Gonda 10E), you will:
  • Administer chemotherapy, immunotherapy, and advanced cancer therapies
  • Support patients through education, therapeutic communication, and emotional care
  • Collaborate with a multidisciplinary team on innovative treatments and research

You'll work with ports, PICC lines, and IV placement while building meaningful relationships with patients throughout their care.
It's fast-paced, complex, and deeply meaningful work.
A place to grow
This team supports you in practicing at the top of your scope while continuing to build your expertise.
You'll have opportunities to precept, develop leadership skills, and grow your confidence and autonomy in daily practice.
You may be a great fit if you:
  • Want work that feels purposeful, not routine
  • Value being part of a supportive, team-oriented environment
  • Take pride in being both highly skilled and deeply compassionate

Position Details
The primary role of the RN in this position is administration of chemotherapeutic agents and patient education in the outpatient setting.
Watch what it's like to be a Chemotherapy Infusion RN at Mayo Clinic
Orientation and Growth
We are committed to helping you feel supported, prepared, and confident as you build your oncology nursing practice.
Your orientation includes:
  • 12+ hours of structured chemotherapy education
  • 12 hours of cancer core knowledge
  • Three months of guided, hands-on learning

You'll work side-by-side with a preceptor to build IV skills, strengthen critical thinking, and grow into the role step by step.
As cancer care continues to evolve, we prepare our nurses not only for today's patients, but for the therapies shaping the future of oncology care.
It's also an exciting time to join our team, with a 15-chair expansion planned for early 2027.
The registered nurse (RN) is accountable for:
  • Coordination of nursing care, including direct patient care, patient/family education and transitions of care.
  • Supporting professional nursing practice across practice settings and across the continuum of care to meet the needs of the patient and family.
  • Functioning within the Mayo Clinic Nursing Professional Practice Model, which includes accountability for planning, implementing, evaluating and communicating all phases of nursing care for assigned patients. The ANA Nursing: Scope and Standards of Practice provide a basis for the practice of the RN.
  • Providing leadership through activities such as preceptor role, informal and formal leadership roles, and quality improvement efforts.
  • Delegating patient care according to skill level, experience, patient acuity, fiscal accountability and availability of resources.
  • Possessing excellent communication skills; is skillful in mentoring and teaching; and may participate on committees or projects.
  • A subset of employees may be required to drive their personal vehicle as a part of the responsibility of their role.

  • This role is eligible for TN sponsorship. Successful sponsorship will require state licensure and completion of the VisaScreen or equivalent certification.

Qualifications
  • Graduate of a nursing program, as recognized by the Accreditation Commission for Education in Nursing (ACEN), Commission on Collegiate Nursing Education (CCNE), National League for Nursing Commission for Nursing Education Accreditation (NLN CNEA).
  • One year of RN experience required.
  • All entry-level associate degree registered nurses with a RN start date of April 1, 2020 and after must provide documented evidence of program completion of the baccalaureate degree in nursing from an accredited nursing program within five years from the last day of the month of the RN start date.
  • All entry-level associate degree registered nurses with a RN start date prior to April 1, 2020 must provide documented evidence of program completion of the baccalaureate degree in nursing from an accredited nursing program as stipulated by the degree requirement program in place at time of hire.

Additional Qualifications:
  • Excellent communication skills (verbal and written).
  • Experience working in a team environment.
  • Computer skills required, prior experience with electronic medical record systems preferred.
  • Ability to adapt to unpredictable situations within the work setting.
  • Demonstrated leadership, effective communicator, and excellent critical thinking skills.

Internal applicants are required to attach their three most recent performance appraisals.
License and Certification (Must obtain prior to start date):
Current RN license by applicable state requirements.
BLS (Basic Life Support) must be valid for 90 days post start date; acceptable certifications include: American Heart Association (AHA)/ Heartcode® BLS, Military Training Network, Red Cross (CPR/AED for Professional Rescuers and Health Care Providers).
Additional state licensure(s) and/or specialty certification/training as required by the work
About Us
Why Mayo Clinic
Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans - to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.
Benefits Highlights
  • Medical: Multiple plan options.
  • Dental: Delta Dental or reimbursement account for flexible coverage.
  • Vision: Affordable plan with national network.
  • Pre-Tax Savings: HSA and FSAs for eligible expenses.
  • Retirement: Competitive retirement package to secure your future.

About the Team
Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is.
Equal Opportunity
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law". Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.

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About Mayo Clinic

Sourced by ZipRecruiter

Mayo Clinic is the largest integrated, not-for-profit medical group practice in the world. We're building the future, one where the best possible care is available to everyone — and more people can heal at home. Our relentless research turns into earlier diagnoses and new cures. That's how we inspire hope in those who need it most. At Mayo Clinic, experts work together to solve the most challenging unmet needs of patients. Our history of innovation dates back almost 150 years, when brothers Will and Charlie Mayo pioneered an integrated, team-based approach to medicine. Today, that trailblazing spirit drives innovations like Mayo Clinic Platform — which powers new technologies to change how care is delivered to all.

Industry

Hospitals

Company size

10,000+ Employees

Headquarters location

Rochester, MN, US

Year founded

1919

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