Description
A postdoctoral training position is available in the laboratory of Dr. Benjamin Sabari, in the Cecil H. and Ida Green Center for Reproductive Biology Sciences at UT Southwestern Medical Center to understand how biomolecular condensates organize gene regulation. Our laboratory has the overarching goal to understand how the machinery required for gene activation is organized within the nucleus in healthy and diseased cell states. The process of gene activation requires hundreds of unique proteins and RNAs that must engage with specific DNA elements to position RNA Polymerase at a gene for transcription. We study the role of dynamic compartments called biomolecular condensates in organizing the transcriptional machinery. We investigate how nuclear condensates form at specific genomic loci, how they function to compartmentalize biochemistry, and how they are dynamically regulated. The lab focuses on the roles of protein disorder, regulatory DNA element clustering, and active processes in the formation and function of nuclear condensates. We investigate these processes in various biological contexts including adipogenesis, stem cell differentiation, and cancer.
Qualifications
Candidates must hold a recent Ph.D. and/or M.D. degree. Experience in any of the following areas: live cell microscopy, in vitro biochemistry, proteomics and epigenomics.
Application Instructions
Interested individuals must upload a CV