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Downstream Process Development Jobs in Gaithersburg, MD

... development lifecycle, automate deployment and security processes, administer critical ... downstream systems. The ideal candidate will have broad technical expertise spanning DevSecOps ...

... development lifecycle, automate deployment and security processes, administer critical ... downstream systems. The ideal candidate will have broad technical expertise spanning DevSecOps ...

... processes, relational or cloud databases, and downstream preservation synchronization ... Advanced Python proficiency, including development, troubleshooting, and maintenance of production ...

Database Engineer

Mclean, VA · On-site

$142K/yr

... downstream processing * Partner with data architecture and domain SMEs to define and maintain data ... Strong experience with API integrations and ETL/ELT development in complex environments.

... downstream processing * Partner with data architecture and domain SMEs to define and maintain data ... Strong experience with API integrations and ETL/ELT development in complex environments.

Data Processing Developer

Columbia, MD · On-site

$150K - $200K/yr

Architect new data processing and presentation systems for downstream users. * Create custom ... Intezra Inc. is a small business prime contractor for all realms of cyber and AI/ML development ...

Showing results 41-60

Downstream Process Development information

See Gaithersburg, MD salary details

$20

$36

$53

How much do downstream process development jobs pay per hour?

As of Sep 12, 2026, the average hourly pay for downstream process development in Gaithersburg, MD is $36.39, according to ZipRecruiter salary data. Most workers in this role earn between $29.86 and $44.66 per hour, depending on experience, location, and employer.

What is downstream process development?

A Downstream Process Development job involves optimizing and scaling purification processes for biologics, such as proteins, antibodies, or gene therapies. Scientists and engineers in this role develop efficient methods for isolation, purification, and formulation of therapeutic products while ensuring quality and regulatory compliance. Key activities include chromatography, filtration, and process analytics to improve yield, purity, and consistency. This role is critical in biotech and pharmaceutical industries to ensure safe and effective drug production for clinical and commercial use.

What does someone in downstream process development do?

Professionals in Downstream Process Development are typically responsible for designing, optimizing, and scaling up purification processes for biopharmaceutical products. Their day-to-day work may involve conducting laboratory experiments, analyzing data, troubleshooting technical issues, and documenting process changes in accordance with regulatory standards. They also frequently collaborate with upstream processing, analytical, and quality teams to ensure seamless transfer and integration of processes. The role often includes participating in project meetings, contributing to process validation efforts, and supporting technology transfer to manufacturing teams, making it both technically challenging and collaborative.

What are the key skills and qualifications needed for downstream process development?

To excel in Downstream Process Development, you generally need a strong background in biochemistry, chemical engineering, or a related life sciences field, often with experience in bioprocessing or purification technologies. Familiarity with chromatography systems, filtration equipment, process analytical technology (PAT), and relevant software such as DeltaV or Unicorn is frequently required, along with knowledge of GMP and regulatory standards. Excellent problem-solving, project management, and cross-functional communication skills help professionals succeed in dynamic team environments. These competencies are crucial for developing efficient, scalable purification processes that ensure high product quality and support organizational goals.

What cities near Gaithersburg, MD are hiring for Downstream Process Development jobs?

Cities near Gaithersburg, MD with the most Downstream Process Development job openings:

Infographic showing various Downstream Process Development job openings in Gaithersburg, MD as of September 2026, with employment types broken down into 92% Full Time, and 8% Contract. Highlights an 81% In-person, 8% Hybrid, and 11% Remote job distribution, with an average salary of $75,697 per year, or $36.4 per hour.

DevSecOps / Sys Admin

Columbia, MD • On-site

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Re-posted 15 days ago


Key responsibilities

  • Design, implement, secure, and maintain development and operational environments across cloud-based, on-premises, and air-gapped systems.

  • Integrate security controls, practices, and testing throughout the software development lifecycle, including automating deployment and security processes.

  • Support system configurations, manage infrastructure, troubleshoot complex issues, and support secure data movement and processing.


Job description

DevSecOps / Systems AdministratorPosition SummaryTOP SECRET/SCI Clearance Required, with a CI POLY
SALARY RANGE:  $210 - 228K
LOCATION:  Columbia, MD

We are seeking an experienced DevSecOps / Systems Administrator to design, implement, secure, and maintain development and operational environments across cloud-based, on-premises, and air-gapped systems. This position will integrate security throughout the software development lifecycle, automate deployment and security processes, administer critical infrastructure, and support the secure movement and processing of data from front-end applications through back-end and downstream systems.

The ideal candidate will have broad technical expertise spanning DevSecOps, systems administration, cybersecurity, cloud infrastructure, server deployment, dataflow architecture, encryption, and compliance. This individual must be comfortable working across multidisciplinary teams and translating technical, security, operational, and customer requirements into reliable and secure solutions.

Key ResponsibilitiesDevSecOps and Security Integration
  • Integrate security controls, practices, and testing throughout the software development lifecycle.

  • Design, implement, and maintain secure CI/CD pipelines.

  • Automate application security testing, vulnerability scanning, compliance checks, and deployment processes.

  • Incorporate security tools into development, build, testing, and release workflows.

  • Conduct security assessments of new and existing systems, applications, and infrastructure.

  • Identify, prioritize, document, and support the remediation of security vulnerabilities.

  • Implement security frameworks, standards, policies, and industry best practices.

  • Monitor systems and infrastructure for security incidents, vulnerabilities, configuration issues, and emerging threats.

  • Develop technical solutions to satisfy system security and data-protection requirements.

  • Establish and publish DevSecOps procedures, technical standards, and security best practices.

Systems and Infrastructure Administration
  • Build, configure, secure, administer, and maintain physical and virtual servers.

  • Support cloud, on-premises, hybrid, and air-gapped computing environments.

  • Manage system configurations, operating systems, user access, permissions, patching, backups, and system availability.

  • Implement and maintain encryption for data at rest and in transit.

  • Monitor the health, performance, reliability, and security of networks, servers, applications, and supporting infrastructure.

  • Troubleshoot complex system, network, application, integration, and deployment issues.

  • Develop infrastructure-as-code solutions to create consistent, repeatable, and secure environments.

  • Support system hardening, configuration management, change management, and lifecycle maintenance.

  • Assist with the integration and administration of Cross Domain Solutions and other controlled data-transfer technologies, as applicable.

Dataflow and Systems Integration
  • Design, implement, and support dataflow architectures that move information securely from front-end systems to back-end services and downstream processing environments.

  • Analyze interfaces, data dependencies, processing requirements, and security boundaries across interconnected systems.

  • Support secure data exchanges among applications, networks, cloud environments, and external systems.

  • Work with software, hardware, and systems engineering teams to integrate system components and resolve technical dependencies.

  • Ensure data-handling solutions comply with applicable security, encryption, access-control, and operational requirements.

Compliance and Authorization Support
  • Support Authorization to Operate activities, including the preparation and maintenance of required security documentation.

  • Assist with security control implementation, assessment, evidence collection, remediation tracking, and audit preparation.

  • Develop and maintain system policies, procedures, diagrams, configuration records, and other technical documentation.

  • Work with cybersecurity, engineering, customer, and program stakeholders to address compliance requirements and authorization findings.

  • Ensure system configurations and operational practices remain consistent with applicable security frameworks and organizational policies.

Collaboration and Operational Support
  • Collaborate closely with software engineers, hardware engineers, systems engineers, cybersecurity personnel, customers, and support operations teams.

  • Provide technical guidance during system design, development, integration, testing, deployment, and operational implementation.

  • Promote shared responsibility for security across development, engineering, and operations teams.

  • Communicate technical risks, system requirements, vulnerabilities, and recommended solutions clearly to both technical and nontechnical stakeholders.

  • Support production deployments, system upgrades, incident response, troubleshooting, and operational transition activities.

  • Evaluate new technologies and recommend improvements to security, automation, scalability, reliability, and system performance.

Required Qualifications
  • Bachelor’s degree in computer science, engineering, information technology, cybersecurity, or a related field, or an equivalent combination of education and relevant experience.

  • At least five years of relevant experience in DevSecOps, systems administration, cloud engineering, cybersecurity engineering, infrastructure engineering, or a related technical field.

  • Strong understanding of DevOps and DevSecOps principles, secure software development practices, and the software development lifecycle.

  • Experience designing, implementing, or maintaining CI/CD pipelines.

  • Hands-on experience with infrastructure automation, configuration management, and version-control technologies.

  • Experience with tools such as:

    • Ansible

    • Jenkins

    • Terraform

    • Git and GitHub

    • GitHub Actions

    • Artifactory

    • Jira

    • Black Duck

    • Comparable DevSecOps, security, and automation platforms

  • Experience building, configuring, securing, and maintaining servers and supporting infrastructure.

  • Experience working in cloud-based, on-premises, hybrid, or air-gapped environments.

  • Knowledge of vulnerability management, secure configuration, access control, encryption, system hardening, and security monitoring.

  • Familiarity with information security frameworks, security controls, and compliance standards.

  • Experience developing technical documentation, operating procedures, security policies, or authorization materials.

  • Strong troubleshooting, analytical, organizational, and communication skills.

  • Demonstrated ability to work effectively across multiple technical disciplines and stakeholder groups.

Preferred Qualifications
  • Eight or more years of experience in DevSecOps, systems administration, cybersecurity, cloud infrastructure, or related roles.

  • Experience supporting highly regulated, government, defense, or other security-sensitive environments.

  • Experience with Authorization to Operate processes and security-control documentation.

  • Experience with Cross Domain Solutions or secure data-transfer systems.

  • Experience designing or supporting dataflow architectures from front-end applications through back-end and downstream processing systems.

  • Experience supporting disconnected, restricted, or air-gapped systems.

  • Knowledge of containerization, orchestration, artifact management, automated code scanning, and software supply-chain security.

  • Experience integrating static application security testing, dynamic application security testing, software-composition analysis, and infrastructure scanning into CI/CD pipelines.

  • Relevant technical or cybersecurity certifications.
    About Oak Leaf Solutions
    Founded in 2008, Oak Leaf Solutions is a mission-driven small business delivering advanced systems engineering, cybersecurity, and technical operations to U.S. Government customers. We specialize in high-impact work that supports national security, while cultivating a culture that values innovation, integrity, and employee well-being. At Oak Leaf, you’ll find a place where your skills make a difference—and where your compensation reflects your value. We offer highly competitive salaries, exceptional benefits, and meaningful opportunities for professional growth. Veterans, reservists, and cleared professionals are strongly encouraged to apply. Learn more at www.oakleafsolutions.net.
    What We Offer
    Our benefits are designed to take care of you—at work, at home, and everywhere in between:

  • Premium Medical Coverage
  • Tricare Supplement Plan – 100% employer-paid for employees, 80% for dependents
  • Dental & Vision Insurance – 100% employer-paid
  • Disability Insurance – 100% employer-paid
  • Life Insurance – $100,000 policy, 100% employer-paid
  • 401(k) with Company Contribution – Pre-tax or Roth, with up to $5,000/year in contributions
  • Generous Paid Leave – 15 PTO days + 11 federal holidays + up to 12 weeks parental leave
  • Professional Development – Up to $5,250/year for certifications, training, and education
  • Wellness Perks – Gym membership reimbursement (up to $50/month) + CareFirst Blue365 discounts
  • Support for Military Families – Pay differential for active duty reserve service
  • …and more.

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