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Downstream Process Development Manager Jobs (NOW HIRING)

Kelly Services

R&D Manager

Lincoln, NE · On-site

Direct bacterial fermentation, downstream concentration and recovery processes, lyophilization process development, optimization, scale-up, and technology transfer activities. * Manage Master Seed ...

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How much do downstream process development manager jobs pay per year?

As of Sep 9, 2026, the average yearly pay for downstream process development manager in the United States is $96,440.00, according to ZipRecruiter salary data. Most workers in this role earn between $80,000.00 and $96,500.00 per year, depending on experience, location, and employer.

What is a downstream process development manager?

A Downstream Process Development Manager is a professional responsible for overseeing the development and optimization of downstream processes in biomanufacturing, particularly the purification and recovery of biological products after fermentation or cell culture. They lead teams in designing, scaling up, and validating processes such as filtration and chromatography to ensure product quality and regulatory compliance. These managers collaborate with cross-functional teams, manage timelines, and troubleshoot technical challenges to streamline production. Their role is critical in ensuring the efficiency and safety of biologic drug manufacturing.

What are the key skills and qualifications needed to thrive as a downstream process development manager, and why are they important?

To thrive as a Downstream Process Development Manager, you need a solid background in biochemistry, chemical engineering, or a related field, often with an advanced degree and industry experience in bioprocessing. Expertise in chromatography systems, filtration technologies, and statistical process control tools, along with familiarity with GMP regulations, is critical. Strong leadership, project management, and cross-functional communication skills help drive innovation and team performance. These competencies ensure efficient process development, regulatory compliance, and successful scale-up of biomanufacturing operations.

What are common challenges faced by downstream process development managers, and how can they be addressed?

Downstream Process Development Managers often encounter challenges such as optimizing purification processes for yield and purity, scaling up from lab to production, and troubleshooting process deviations. Addressing these issues requires strong collaboration with upstream teams, analytical departments, and manufacturing. Staying current with emerging technologies, maintaining robust documentation, and fostering a culture of continuous improvement are key to successfully overcoming these hurdles and ensuring efficient process transfer to manufacturing.

What cities are hiring for Downstream Process Development Manager jobs?

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What are the most commonly searched types of Downstream Process Development jobs?

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Infographic showing various Downstream Process Development Manager job openings in the United States as of June 2026, with employment types broken down into 83% Full Time, 14% Part Time, 1% Temporary, and 2% Contract. Highlights an 86% Physical, 3% Hybrid, and 11% Remote job distribution, with an average salary of $96,440 per year, or $46.4 per hour.

Process Engineer, downstream purification

Lexington, MA • On-site

Integrated Resources INC
Recruiting and Staffing Services • 51 - 200 employees
Learn more about Integrated Resources INCexternal

Contractor

Re-posted 22 hours ago

Job description

Company Description

A Few Words About Us
Integrated Resources, Inc is a premier staffing firm recognized as one of the tri-states most well-respected professional specialty firms. IRI has built its reputation on excellent service and integrity since its inception in 1996. Our mission centers on delivering only the best quality talent, the first time and every time. We provide quality resources in four specialty areas: Information Technology (IT), Clinical Research, Rehabilitation Therapy and Nursing.

Job Description

As a member of the Manufacturing Science & Technology group in Process Development department, this individual will join a group of process scientist and engineers to support downstream processes of commercial productions and late stage clinical process development and productions. The scope of work will include designing studies under instruction, executing experiments and data analysis to support GMP investigations and manufacturing change controls and to reduce reoccurring deviations. The focus of the work will be downstream unit operations such as column chromatography, harvest clarification, TFF and normal flow filtration. This individual will interact with other PD groups and other departments including manufacturing, PTS, QC, QA and Engineering etc.


BS degree in Chemical Engineering, Biochemistry/Protein Chemistry or related disciplines with 0-3 years of relevant experience in a biotechnology/pharmaceutical environment is required.

Experience with column chromatography and TFF is required. Knowledge of the quality systems and other regulatory requirements necessary to manufacture biologics in a cGMP environment is preferred.

The successful candidate must:

Have hands-on downstream process development experience

Be able to learn to work independently and on cross-functional teams

Have good written and verbal communication skills


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Additional Information

Archana Melwani

Clinical Recruiter

Integrated Resources, Inc

IT REHAB CLINICAL NURSING

Inc. 5000 - 2007-2014 (8th Year)

Certified MBE I GSA - Schedule 66 I GSA - Schedule 621I I GSA - Schedule 70

Tel: 732-549-2030 x130

Direct: 732-429-1853

Fax: 732-549-5549





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About Integrated Resources

Sourced by ZipRecruiter

Integrated Resources Inc (IRI), based in Edison, NJ, US, is an esteemed player in the staffing solutions industry with a credible presence on their official website irionline.com. Notably, IRI provides a range of professional staffing services including contract, contract-to-hire, and direct hire solutions to a wide spectrum of industries such as healthcare, life sciences, manufacturing, financial, insurance, and others. Since its inception, IRI has been committed to delivering top-talent and optimum solutions to meet its clients' diverse needs.

Industry

Recruiting and staffing services

Company size

51 - 200 Employees

Headquarters location

Edison, NJ, US

Year founded

1996

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