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Dna Encoded Libraries Jobs in San Ramon, CA (NOW HIRING)

Earli, Inc.

Senior Scientist, Bio AI

Redwood City, CA · On-site

$205K - $235K/yr

... DNA in a stealth LNP. Once activated, they force the cancer cells to produce encoded proteins - T ... libraries of DNA or RNA sequences * Proficiency in routine bioinformatic analyses such as ...

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Dna Encoded Libraries information

What are the key skills and qualifications needed to thrive as a DNA Encoded Libraries (DEL) Scientist, and why are they important?

To thrive as a DNA Encoded Libraries (DEL) Scientist, you need a solid background in chemistry, molecular biology, and drug discovery, usually with an advanced degree (PhD or MSc) in a relevant field. Familiarity with DEL technology platforms, high-throughput screening systems, and data analysis software is typically required. Strong problem-solving skills, attention to detail, and effective cross-disciplinary communication help individuals excel in this role. These competencies are crucial for efficiently designing, executing, and interpreting DEL experiments that accelerate the identification of new therapeutic compounds.

What are some typical challenges faced by scientists working with DNA-encoded libraries (DELs), and how can they be addressed?

Scientists working with DNA-encoded libraries often encounter challenges such as maintaining the integrity of DNA tags during chemical synthesis, ensuring efficient library encoding, and accurately decoding hits after screening. Addressing these issues requires careful optimization of reaction conditions to prevent DNA degradation, thorough validation of encoding and decoding steps, and close collaboration with bioinformatics specialists to analyze sequencing data. Working in multidisciplinary teams and staying current with advances in DEL technology can also help scientists overcome technical hurdles and contribute to successful drug discovery campaigns.

What are DNA Encoded Libraries?

DNA Encoded Libraries (DELs) are collections of small molecules that are each attached to a unique DNA sequence acting as a molecular barcode. This technology allows researchers to rapidly screen millions to billions of compounds simultaneously to identify those that bind to a biological target, which is especially useful in early-stage drug discovery. The DNA tags make it possible to track and identify active compounds using DNA sequencing techniques, greatly increasing throughput and efficiency compared to traditional screening methods.

What is the difference between Dna Encoded Libraries vs Synthetic Chemistry Chemist?

AspectDna Encoded LibrariesSynthetic Chemistry Chemist
Required CredentialsTypically a background in molecular biology, biochemistry, or related fields; often with experience in library synthesis and screeningUsually a degree in chemistry or chemical engineering; expertise in organic synthesis and reaction mechanisms
Work EnvironmentLaboratory focused on high-throughput screening, drug discovery, and molecular biology techniquesLaboratories or industrial settings focused on chemical synthesis, process development, and compound optimization
Industry UsagePrimarily used in pharmaceutical and biotech industries for drug discoveryUsed across pharmaceuticals, materials science, and chemical manufacturing

In summary, Dna Encoded Libraries specialists focus on creating and screening vast collections of DNA-tagged molecules for drug discovery, requiring expertise in molecular biology. Synthetic Chemistry Chemists concentrate on designing and synthesizing chemical compounds through organic reactions, emphasizing chemical expertise. Both roles are essential in the pharmaceutical industry but differ in their techniques and focus areas.

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Dna Encoded Libraries jobs near you

SRA DNA Encoded Library Technology - (Brisbane, CA)

Nurix, Inc.

Brisbane, CA • On-site

$118.89K - $139.31K/yr

Other

Posted 13 days ago

Job description

Company
Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease.
Research Associate III/Scientist I, DNA Encoded Library Technology - Nurix Brisbane
Position
We are seeking a talented and motivated chemist to join our Discovery Chemistry team and contribute to the design and synthesis of DNA-encoded libraries (DELs). This hands-on position offers the opportunity to shape Nurix's DEL-based lead discovery platform, working at the interface of chemistry, biology, and automation. Key responsibilities:
  • Design and validate novel DEL library builds.
  • Develop and bring in new DNA-compatible chemical transformations that can widen the DEL chemical space.
  • Construct DEL libraries to support the in-house library production efforts.
  • Work with external partners to support our DEL synthesis and hit follow up strategies.
  • Engage in cross-functional team discussions that support DEL screening, data analysis, machine learning and hit-optimization.
  • Contribute to platform automation and technology development efforts.
  • Present results, document workflows, and contribute to scientific and strategic planning within the Discovery Chemistry organization.
Education and Experience
  • B.S. or higher in Chemistry, Biochemistry, or Medicinal Chemistry. 2-5 years of industrial experience (title determined by experience).
  • Strong background in synthetic organic chemistry.
  • Hands-on laboratory experience synthesizing DNA encoded libraries.
  • Familiar with the overall DNA-Encoded Library Technology workflow operations.
  • Experience analyzing and purifying DNA-conjugates using common analytical tools (LCMS/HPLC).
Added Qualifications
  • Experience working in the drug discovery field - drug design, synthesis, and SAR based hit-to-lead optimization.
  • Experience working with high-throughput analytical and purification systems relevant to DEL-applications.
  • Experience working with molecular biology tools (PCR, qPCR, Western Blot).
Fit with Nurix Culture and Values
  • Collaborative and team-oriented, eager to share expertise and learn from others.
  • Solution-driven with a hands-on and resourceful approach.
  • Adaptable and comfortable in a fast-paced, interdisciplinary environment.
  • Committed to scientific excellence and the shared goals of the team.

Location: Brisbane, CA
Salary Range:
RA III: $101,690 - 116,226
SRA: $118,893 - 139,310
Scientist I: $129,382 -146,679
Application Process
Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.
Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.
Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix. By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/).

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