Previous experience with RNA-seq data analysis, DNA encoded library design and screening, and structure-based design is also desirable. Highly motivated candidates possessing a strong academic track ...
Previous experience with RNA-seq data analysis, DNA encoded library design and screening, and structure-based design is also desirable. Highly motivated candidates possessing a strong academic track ...
Dna Encoded Libraries information
What is a DNA encoded library?
DNA Encoded Libraries (DELs) are collections of small molecules that are each attached to a unique DNA sequence acting as a molecular barcode. This technology allows researchers to rapidly screen millions to billions of compounds simultaneously to identify those that bind to a biological target, which is especially useful in early-stage drug discovery. The DNA tags make it possible to track and identify active compounds using DNA sequencing techniques, greatly increasing throughput and efficiency compared to traditional screening methods.
What skills and qualifications are needed to thrive as a DNA encoded libraries scientist?
To thrive as a DNA Encoded Libraries (DEL) Scientist, you need a solid background in chemistry, molecular biology, and drug discovery, usually with an advanced degree (PhD or MSc) in a relevant field. Familiarity with DEL technology platforms, high-throughput screening systems, and data analysis software is typically required. Strong problem-solving skills, attention to detail, and effective cross-disciplinary communication help individuals excel in this role. These competencies are crucial for efficiently designing, executing, and interpreting DEL experiments that accelerate the identification of new therapeutic compounds.
What are typical challenges faced by scientists working with DNA encoded libraries, and how can they be addressed?
Scientists working with DNA-encoded libraries often encounter challenges such as maintaining the integrity of DNA tags during chemical synthesis, ensuring efficient library encoding, and accurately decoding hits after screening. Addressing these issues requires careful optimization of reaction conditions to prevent DNA degradation, thorough validation of encoding and decoding steps, and close collaboration with bioinformatics specialists to analyze sequencing data. Working in multidisciplinary teams and staying current with advances in DEL technology can also help scientists overcome technical hurdles and contribute to successful drug discovery campaigns.
What is the difference between Dna Encoded Libraries vs Synthetic Chemistry Chemist?
| Aspect | Dna Encoded Libraries | Synthetic Chemistry Chemist |
|---|---|---|
| Required Credentials | Typically a background in molecular biology, biochemistry, or related fields; often with experience in library synthesis and screening | Usually a degree in chemistry or chemical engineering; expertise in organic synthesis and reaction mechanisms |
| Work Environment | Laboratory focused on high-throughput screening, drug discovery, and molecular biology techniques | Laboratories or industrial settings focused on chemical synthesis, process development, and compound optimization |
| Industry Usage | Primarily used in pharmaceutical and biotech industries for drug discovery | Used across pharmaceuticals, materials science, and chemical manufacturing |
In summary, Dna Encoded Libraries specialists focus on creating and screening vast collections of DNA-tagged molecules for drug discovery, requiring expertise in molecular biology. Synthetic Chemistry Chemists concentrate on designing and synthesizing chemical compounds through organic reactions, emphasizing chemical expertise. Both roles are essential in the pharmaceutical industry but differ in their techniques and focus areas.
What are popular job titles related to Dna Encoded Libraries jobs in Florida?
For Dna Encoded Libraries jobs in Florida, the most frequently searched job titles are:
What job categories do people searching Dna Encoded Libraries jobs in Florida look for?
The top searched job categories for Dna Encoded Libraries jobs in Florida are:
What cities in Florida are hiring for Dna Encoded Libraries jobs?
Cities in Florida with the most Dna Encoded Libraries job openings:
Postdoctoral Associate - Disney Lab
Palm Beach, FL • On-site
University of Florida
• Colleges, Universities, and Professional Schools • 5 - 10K employees5,001 - 10,000 employees
Full-time
Re-posted 25 days ago
University Of Florida rating
7.2
Based on 108 frontline employees who took The Breakroom Quiz
Job description
Postdoctoral Associate - Disney Lab
Apply now Job no: 539984
Work type: Post Doc Associate
Location: Palm Beach
Categories: Biology/Life Science, Grant or Research Administration, Physical/Mathematical Sciences
Department:37041030 - SR-CHEM-DISNEY LAB
Classification Title:
Postdoctoral Associate
Classification Minimum Requirements: Qualified applicants should have completed a relevant Ph.D. degree in structural biology, chemical biology, or organic/medicinal chemistry. Job Description:Effective immediately, the Disney group in the Department of Chemistry at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology (https://disney.scripps.ufl.edu) is seeking to hire a Postdoctoral Associate in RNA Chemical Biology.
Lab Overview:
The Disney group is a chemical biology laboratory focused on developing rational approaches to design highly selective therapeutics from only genome sequence. Known for its prolific output and pioneering research culture, the group has furthered advancements in annotating RNA structure from sequence alongside several novel technologies created in-house. The laboratory's targeting of RNA by small molecules, an ambitious and highly focused enterprise in pursuit of chemical probe and lead medicine development, is summarized in Nature Reviews Drug Discovery (2023) 618(7963): 169-179.
Other representative publications from the Disney group include:
Studying disease mediated by RNA repeat expansions that cause genetically defined ALS and dementia:
o Science Translation Medicine (2021) 13:eabd5991; doi: 10.1126/scitranslmed.abd5991
o Neuron (2014) 83:1043-50; doi: 10.1016/j.neuron.2014.07.041
o Cell Chemical Biology (2019) 26:179-190; doi: 10.1016/j.chembiol.2018.10.018
Targeted RNA degradation and related technologies:
o Nature Reviews Drug Discovery (2023) 618(7963): 169-179; doi: 10.1038/s41586-023-06091-8
o Journal of the American Chemical Society (2021) 143:13044-13055; doi: 10.1021/jacs.1c02248
o Science Translation Medicine (2021) 13:eabd5991; doi: 10.1126/scitranslmed.abd5991
o Proceedings of the National Academy of Sciences USA (2020) 117:2406-2411; doi: 10.1073/pnas.1914286117
o Proceedings of the National Academy of Sciences USA (2019) 116:7799-7804; doi: 10.1073/pnas.1901484116
o Journal of the American Chemical Society (2018) 140:6741-6744; doi: 10.1021/jacs.8b01233
o Nature Chemical Biology (2017) 13:188-193; doi: 10.1038/nchembio.225
Precision targeted therapeutics for difficult-to-treat cancers and other diseases:
o Journal of the American Chemical Society (2019) 141:2960-2974; doi: 10.1021/jacs.8b10558
o Cell Chemical Biology (2018) 25:1086-1094; doi: 10.1016/j.chembiol.2018.05.01
o Proceedings of the National Academy of Sciences USA (2016) 113:5898-903; doi: 10.1073/pnas.1523975113
o Proceedings of the National Academy of Sciences USA (2020) 117:1457-1467; doi: 10.1073/pnas.190505711
Our Commitment: The Disney group is highly committed to each individual's professional development during his or her time in the lab. A high impact research project and training plan to support the achievement of short-term as well as long-term career goals is customized for each student.
Expected Salary:Commensurate with experience.
Required Qualifications:Qualified applicants should have completed a relevant Ph.D. degree in structural biology, chemical biology, or organic/medicinal chemistry.
Preferred:Preference will be given to candidates with strong skills in RNA biology techniques, molecular biology, and biochemical methods. Previous experience with RNA-seq data analysis, DNA encoded library design and screening, and structure-based design is also desirable.
Highly motivated candidates possessing a strong academic track-record, a high-impact publication list, a team-player mentality, and an interest in targeting the RNA world are poised for success in the group.
The Disney group employs a broad range of experimental techniques, and thus a wide set of research skills is preferable, and a willingness to learn new methods is essential.
Special Instructions to Applicants:In order to be considered, you must upload your cover letter and resume.
The final candidate will be required to provide official transcript to the hiring department upon hire. A transcript will not be considered "official" if a designation of "Issued to Student" is visible. Degrees earned from an education institution outside of the United States are required to be evaluated by a professional credentialing service provider approved by National Association of Credential Evaluation Services (NACES), which can be found at http://www.naces.org/.
Please provide names and email addresses of three to five references as part of the UF application process. When ready, the hiring department will contact the listed references via email requesting their reference letters to be uploaded directly to the application website.
This position is open until filled. Application review will begin May 29, 2026.
This is a time-limited position.
This requisition is being used to fill multiple positions.
The University of Florida is a member of the State University System of Florida and an Equal Opportunity Employer. All qualified applicants will receive consideration for employment based on merit.
If an accommodation due to a disability is needed to apply for this position, please call 352-392-2477 or the Florida Relay System at 800-955-8771 (TDD) or visit Accessibility at UF.
Advertised: 22 May 2026 Eastern Daylight Time
Applications close:
Back to search results Apply nowRefer a friend
Whatsapp Facebook LinkedIn Email App
What University Of Florida employees say
Pay
Benefits
Hours and flexibility
Workplace
Get the full story on Breakroom
About University of Florida
Sourced by ZipRecruiter
The University of Florida is one of the top ranked public universities in the United States (ranked top 5 amongst public universities in 2023 US news and world report). It is one of only a few comprehensive universities, having medical, veterinary, dental, nursing, public health, and engineering disciplines all co-localized on the same, contiguous campus to facilitate interdisciplinary collaboration. Gainesville is located in the northern region of Florida, within 1-1.5 hours of each coast, and just 1.5-2 hours to Orlando and Tampa. It is a small to medium-sized city with a low cost of living, excellent public and private schools, and southern hospitality. While Gainesville is widely recognized as the home of the Gators, it is quickly becoming known as a center for innovation and a place with a lifestyle that's comfortable for families, yet attractive for young professionals.
Industry
Colleges, universities, and professional schools
Company size
5,001 - 10,000 Employees
Headquarters location
Gainesville, FL, US
Year founded
1853