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Postdoctoral Associate, Pharmacology, Physiology & Biophysics, Chobanian & Avedisian School of Medic

Boston, MA • On-site

Boston University
Colleges, Universities, and Professional Schools • 10K+ employees
Learn more about Boston Universityexternal

Full-time

Re-posted 17 days ago

Boston University rating

7.9

Company rating: 7.9 out of 10

Based on 51 frontline employees who took The Breakroom Quiz

213th of 633 rated colleges and universities

Job description

The TCW laboratory (https://sites.bu.edu/tcwlab/) in the Department of Pharmacology, Physiology & Biophysics at Boston University Chobanian & Avedisian School of Medicine in Boston, Massachusetts is looking for highly motivated and skilled stem cell biologists or electrophysiologists to be the drivers of our efforts to translate the genetics of human AD toward therapeutic interventions.
The core program is to translate AD genetics and functional genomics into human brain cells both in vitro 2D and 3D models using human induced pluripotent stem cells (hiPSCs) from population and isogenic lines generated by CRISPR/Cas9 genome editing and in vivo hiPSC/rodent chimera systems in comparison with post-mortem brain. In particular, the research will focus on deciphering the molecular mechanism of major AD risk variants as well as protective variants, associated genes and identifying targeted therapeutics. Furthermore, the research focusing on human iPSC-glial transplantation in AD animal models followed by in vivo electrophysiological and behavior readouts will enable potential stem cell therapeutics. The candidate will join a multidisciplinary and highly collaborative research team that includes computational geneticists, neuroscientists and pharmacologists in the department as well as Genome Science Institute and Center for Systems Neuroscience at Boston University.

Interested candidates should submit a cover letter outlining their research interests and career goals, a current CV, and contact information for three references to Dr. Julia TCW, Assistant professor and Director [juliatcw@bu.edu] or https://sites.bu.edu/tcwlab/talent-aquisition/.

Review of applications will begin immediately and continue until the position is filled.


Required Skills
  • Experienced in handling stem cells (mouse or human iPSCs, embryonic stem cells) and brain cell differentiation (2D or 3D cell cultures), or Experienced in electrophysiology (in vivo ephys, Ca imaging, MEA, path clamping), animal behaviors
  • (Plus) CRISPRa/i screens, genome-editing
  • Clear written and oral communication and detailed documentation skills, with the ability to collaborate effectively across disciplines

We are an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to race, color, natural or protective hairstyle, religion, sex, age, national origin, physical or mental disability, sexual orientation, gender identity, genetic information, military service, pregnancy or pregnancy-related condition, or because of marital, parental, or veteran status. We are a VEVRAA Federal Contractor. 


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About Boston University

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Boston University is an international, comprehensive, private research university, committed to educating students to be reflective, resourceful individuals ready to live, adapt, and lead in an interconnected world. Boston University is committed to generating new knowledge to benefit society. We remain dedicated to our founding principles: that higher education should be accessible to all and that research, scholarship, artistic creation, and professional practice should be conducted in the service of the wider community—local and international. These principles endure in the University’s insistence on the value of diversity, in its tradition and standards of excellence, and in its dynamic engagement with the City of Boston and the world. Boston University comprises a remarkable range of undergraduate, graduate, and professional programs built on a strong foundation of the liberal arts and sciences. With the support and oversight of the Board of Trustees, the University, through our faculty, continually innovates in education and research to ensure that we meet the needs of students and an ever-changing world.

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10,000+ Employees

Headquarters location

Boston, MA, US

Year founded

1839

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