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Director Ctms Operations Jobs (NOW HIRING)

WHOOP

Director, Clinical Operations

Boston, MA · On-site

As the Director, Clinical Operations, you will lead the clinical operations function responsible ... CTMS, eConsent, ePRO, eTMF, and remote study platforms. * Oversee study startup and regulatory ...

Otsuka

Director, Clinical Technical Operations

The Director, Clinical Technical Operations provides leadership and oversight for the technology ... CTMS, eTMF, Master Data Management tools, digital trial technologies, study start-up systems ...

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Director Ctms Operations information

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$34K

$107.7K

$179.5K

How much do director ctms operations jobs pay per year?

As of Sep 14, 2026, the average yearly pay for director ctms operations in the United States is $107,680.00, according to ZipRecruiter salary data. Most workers in this role earn between $75,500.00 and $135,500.00 per year, depending on experience, location, and employer.

What is a Director CTMS Operations?

A Director of CTMS Operations is a senior leader responsible for overseeing the management, implementation, and optimization of Clinical Trial Management Systems (CTMS) within a healthcare or pharmaceutical organization. This role involves developing strategies for CTMS deployment, ensuring data integrity and compliance with regulatory standards, and managing cross-functional teams to support clinical research operations. The Director collaborates with IT, clinical, and regulatory teams to streamline workflows and improve the efficiency of clinical trial processes. They also play a key role in training staff and ensuring that the CTMS supports organizational goals and industry best practices.

What are the key skills and qualifications needed to thrive as a Director CTMS Operations?

To thrive as a Director CTMS Operations, you need in-depth knowledge of clinical trial management systems, strong project management abilities, and typically a degree in life sciences or related fields. Expertise with CTMS platforms (such as Medidata, Oracle, or Veeva), regulatory compliance tools, and possibly certifications in clinical research are highly valuable. Leadership, strategic thinking, and excellent interpersonal skills help drive cross-functional collaboration and manage complex projects. These competencies are essential for ensuring efficient clinical trial execution, regulatory adherence, and successful team leadership in a dynamic environment.

What are some common challenges faced by a Director CTMS Operations, and how can they be addressed?

Directors of CTMS (Clinical Trial Management System) Operations often encounter challenges such as integrating new technologies with legacy systems, ensuring data integrity, and managing cross-functional teams across global locations. Addressing these challenges requires strong project management skills, clear communication, and a proactive approach to change management. Building collaborative relationships with IT, clinical, and regulatory teams is essential for successful system implementations and ongoing process improvements.

What is the difference between Director Ctms Operations vs Clinical Trial Manager?

AspectDirector Ctms OperationsClinical Trial Manager
CredentialsTypically requires advanced degrees (e.g., Master’s, PhD) and extensive experience in clinical operationsUsually requires a bachelor’s or master’s degree in life sciences or related field, with relevant clinical trial experience
Work EnvironmentOversees multiple projects and teams, strategic planning, and high-level decision-making in clinical operationsManages individual clinical trials, coordinates activities, and ensures trial compliance and progress
Industry UsageCommonly used in pharmaceutical and biotech companies for senior operational leadershipUsed across clinical research organizations and sponsors for trial management

The main difference is that the Director Ctms Operations holds a senior leadership role overseeing multiple trials and teams, focusing on strategic and operational oversight. In contrast, the Clinical Trial Manager manages specific trials, focusing on day-to-day trial execution and compliance.

What are popular job titles related to Director Ctms Operations jobs?

For Director Ctms Operations jobs, the most frequently searched job titles are:

Infographic showing various Director Ctms Operations job openings in the United States as of September 2026, with employment types broken down into 1% As Needed, 80% Full Time, 16% Part Time, 1% Temporary, 1% Contract, and 1% Nights. Highlights an 93% Physical, 2% Hybrid, and 5% Remote job distribution, with an average salary of $107,680 per year, or $51.8 per hour.

Vice President, Clinical Operations

Remote

4D Molecular Therapeutics
Biotechnology Research and Development • 1 - 10 employees
Learn more about 4D Molecular Therapeuticsexternal

Full-time

Re-posted 9 days ago

Job description

General Summary:

Vice President, Clinical Operations is responsible for strategic operational oversight and execution of one or more complex global clinical programs across the ophthalmology and/or broader portfolio. Reporting to the Chief Clinical Operations Officer, this role ensures clinical trials are planned and executed with excellence, delivering high-quality, inspection-ready data on time and within budget.

The VP provides leadership to Clinical Operations teams responsible for study execution and partners closely with cross-functional development teams, including Clinical Science, Medical, Regulatory, Data Sciences, Clinical Compliance, Quality, and Business Operations, to proactively identify and mitigate operational risks, optimize trial performance, and drive executional excellence across Phase 1-3 clinical development.

The VP fosters a culture of operational excellence by building scalable systems, standardized processes, and performance metrics that enable predictable execution, informed decision-making, and continuous improvement. This leader creates an environment where decisions are driven by objective data and operational metrics rather than individual effort.

Major Duties and Responsibilities: 

Clinical Trial Execution & Oversight

  • Provide operational leadership and oversight for one or more large global clinical development programs or multiple phase 1-2 clinical studies from study start-up through database lock.
  • Ensure clinical trials are executed according to timelines, quality standards, budget, and corporate objectives.
  • Lead Clinical Operations teams to proactively identify risks, develop mitigation plans, and resolve operational challenges.
  • Ensure consistent execution of operational strategy across studies while maintaining inspection readiness.
  • Drive study performance through key operational metrics and continuous improvement initiatives.

 Leadership & Team Management

  • Lead, mentor, and develop Clinical Operations leaders (Senior Directors, Directors, CTMs) responsible for study execution.
  • Foster a culture of accountability, collaboration, operational excellence, and continuous improvement.
  • Build organizational capability through coaching and talent development.

Cross-functional Leadership

  • Partner with Clinical Science, Regulatory, Data Sciences/Medical, Clinical Compliance, Quality, Pharmacovigilance, and Technical Operations to ensure seamless trial execution.
  • Represent Clinical Operations on cross-functional program teams.
  • Escalate critical operational issues and recommend solutions to executive leadership.

Vendor & Financial Oversight

  • Provide executive oversight of CROs and strategic vendors supporting assigned programs.
  • Partner with Clinical Compliance to establish and maintain risk-proportionate sponsor oversight of vendors and delegated trial activities, ensuring documented oversight processes, issue escalation, and continuous evaluation of performance and compliance.
  • Partner with Clinical Outsourcing and Business Operations to ensure vendor performance, governance, and accountability.
  • Oversee study budgets, forecasts, change orders, and resource planning.

Operational Excellence

  • Drive inspection readiness across assigned programs.
  • Ensure adherence to GCP, SOPs, regulatory requirements, and quality standards.
  • Develop and implement scalable operational processes and governance that improve execution efficiency, consistency, and inspection readiness.
  • Establish and monitor key performance indicators (KPIs) and operational metrics to proactively identify risks, measure performance, and drive continuous improvement.
  • Utilize data and performance analytics to support operational decision-making, resource planning, and study execution.
  • Drive a culture of operational excellence through standardization, accountability, and continuous process improvement.

Core Competencies

  • Demonstrated success leading execution of complex global Phase 1-3 clinical trials.
  • Proven ability to lead multiple Clinical Operations trial teams across concurrent programs.
  • Strong systems thinker with the ability to design scalable processes that support organizational growth.
  • Demonstrated ability to leverage metrics, dashboards, and operational analytics to drive performance and informed decision-making.
  • Experience implementing process improvements that increase efficiency, quality, and execution predictability.
  • Ability to translate operational data into actionable insights and measurable business outcomes.
  • Experience leading global CROs and strategic vendor partnerships.
  • Excellent leadership, coaching, and organizational development skills.
  • Ability to influence cross-functional teams without direct authority.
  • Executive presence with concise communication and strong decision-making skills.
  • Deep knowledge of ICH-GCP, FDA, EMA, and global clinical trial regulations.

Qualifications:

  • Bachelor's degree in a scientific, business or health-related discipline.
  • 15+ years of Clinical Operations experience in biotechnology or pharmaceutical development.
  • Significant experience leading global Phase 1-2 and/or Phase 3 clinical trials.
  • Experience participating in regulatory authority inspections supporting global clinical development programs.
  • 6+ years of people leadership, including managing senior Clinical Operations leaders.
  • Ophthalmology (retina) clinical development experience strongly preferred.
  • Demonstrated success overseeing large global programs or multiple concurrent studies with significant operational complexity.

Travel: 5%

Physical Requirements and Working Conditions:

  • Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met.
  • Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work).

Base salary compensation range: $310,000 - $365,000

Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate's geographical location, relevant work experience, skills, and years of experience. 

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