To thrive as a Detox RN, you need a solid background in nursing assessment, medication administration, withdrawal management, and patient safety, supported by state RN licensure and often experience in mental health or substance abuse settings. Familiarity with detox protocols, electronic health records (EHR), and certification in Basic Life Support (BLS) or Advanced Cardiac Life Support (ACLS) are commonly required. Strong interpersonal communication, crisis intervention, and compassionate care are key soft skills that distinguish top performers in this role. These skills are vital for safely guiding patients through withdrawal, supporting recovery, and ensuring a therapeutic environment.