Data Foundry Jobs (NOW HIRING)

San Diego, CA; San Francisco, CA; Boston, MA; Louisville, CO; Indianapolis, IN

Lead, Data Architecture (R9), Architecture4Insight

Lilly is a global healthcare leader headquartered in Indianapolis, Indiana, focused on discovering and delivering life‑changing medicines.

The Data Foundry is a multidisciplinary team within Discovery Technology and Platforms (DTP) enabling AI‑native drug discovery through four pillars: Architecture4Insight, Methods4Insight, Automation & Scale4Insight, and Preparedness4Insight.

We are seeking Data Architects at multiple levels to design and build the data infrastructure that enables AI‑native drug discovery. The role builds schemas, ontologies, data models, knowledge graphs, and platform architectures for scientific data.

• Design and implement data models, schemas, and ontologies for chemical, biological, and automation‑generated data that serve discovery workflows across the portfolio.
• Define and maintain controlled vocabularies, metadata standards, and FAIR‑compliant data frameworks in partnership with Preparedness4Insight.
• Implement semantic data standards (RDF, OWL, SPARQL) and ontology engineering practices to create interoperable, machine‑readable scientific data.

• Design and implement data lakehouse architecture using modern platforms (Databricks, Snowflake, or equivalent), including data storage patterns, partitioning strategies, and query optimization.
• Build and optimize ETL/ELT pipelines using Spark, dbt, or similar tools to transform raw scientific data into analytical and ML‑ready formats.
• Implement real‑time and streaming data integration (Kafka, Kinesis, event‑driven patterns) connecting LIMS, instruments, and lab automation systems to the data infrastructure.

• Design and implement knowledge graphs (Neo4j, Amazon Neptune, TigerGraph) that capture molecular, target, pathway, and experimental relationships across the discovery landscape.
• Architect specialized data solutions: array databases (TileDB) for genomics/imaging, document stores (MongoDB) for experimental records, and vector databases for embedding‑based retrieval supporting ML and RAG workflows.
• Build query and traversal patterns that enable scientists and AI agents to ask relational questions across the entire data landscape.

• Partner with scientific software engineers to ensure data architectures are implementable, performant, and well‑documented.
• Collaborate with Methods4Insight to design data structures that support analytical model training, deployment, and evaluation.
• Work with Tech@Lilly to define scaling strategies, ensure enterprise compliance, and transition data architectures to production‑grade management.
• Contribute to build‑versus‑buy‑versus‑adopt decisions by evaluating commercial and open‑source data platforms against Data Foundry requirements.

• M.S. or PhD in Computer Science, Data Science, Bioinformatics, Computational Biology, Information Science, or related STEM field
• MS (with 6+ years) and PhD (with 2+ years) of data architecture, data engineering, or scientific informatics experience.
• Deep expertise in at least one of the focus areas: relational databases, data modeling and ontology engineering, data platform and lakehouse architecture (Databricks, Snowflake, Spark), or knowledge graph and specialized database systems (Neo4j, Neptune, MongoDB, TileDB).

• Working familiarity with multiple database paradigms — relational, graph, document, columnar, key‑value — and strong SQL skills.
• Understanding of scientific data types and experimental workflows in life sciences or pharma (chemical, biological, HTE data).
• Strong communication skills with ability to translate data architecture concepts for both technical and scientific audiences.
• Familiarity with cloud platforms (AWS, Azure, or GCP) and modern data integration patterns.
• Pharmaceutical or biotech research industry experience, particularly in discovery data management or research informatics.
• Experience with semantic web technologies: RDF, OWL, SPARQL, Protégé, or equivalent ontology engineering tools.
• Hands‑on experience with graph databases (Neo4j, Neptune, TigerGraph) and knowledge graph design patterns for scientific data.
• Data lakehouse architecture experience: Databricks (Delta Lake, Unity Catalog), Snowflake, or equivalent; ETL/ELT with Spark, dbt.
• Experience with streaming/real‑time data platforms (Kafka, Kinesis, Flink) and event‑driven architectures.
• Familiarity with LIMS, ELN systems (e.g., Benchling), and laboratory instrument data integration.
• Experience with vector databases (Pinecone, Weaviate, pgvector) and embedding‑based retrieval for ML/RAG applications.
• Array database experience (TileDB, Zarr) for genomics, imaging, or high‑dimensional scientific data.
• FAIR data principles implementation experience and Data Readiness Level frameworks.
• Scientific data standards and controlled vocabularies in chemistry (InChI, SMILES) or biology (Gene Ontology, UniProt).
• Experience with C, C++, or Rust for performance‑critical data processing; familiarity with HPC data I/O patterns for large‑scale scientific computations.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position ranges from $151,500 to $222,200. Full‑time equivalent employees will be eligible for a company bonus (depending, in part, on company and individual performance). Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company‑sponsored 401(k); pension; vacation benefits; medical, dental, vision, and prescription drug benefits; flexible benefits (healthcare and/or dependent day‑care flexible spending accounts); life insurance and death benefits; time‑off and leave of absence benefits; and well‑being benefits (employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce. If you require accommodation, please complete the accommodation request form for further assistance.