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What are the key skills and qualifications needed to thrive as a Cryo-EM Postdoctoral Researcher, and why are they important?

To thrive as a Cryo-EM Postdoctoral Researcher, you need advanced knowledge in structural biology, electron microscopy techniques, and a PhD in a relevant field such as biochemistry or biophysics. Expertise in using cryo-electron microscopes, image processing software (e.g., RELION, CryoSPARC), and data analysis pipelines is typically required. Strong problem-solving abilities, attention to detail, and effective communication skills distinguish top candidates in this role. These qualifications are crucial for conducting high-quality research, collaborating across multidisciplinary teams, and advancing structural biology discoveries.

What are some common challenges faced by postdoctoral researchers working with Cryo-EM, and how can they be addressed?

Postdoctoral researchers in Cryo-Electron Microscopy (Cryo-EM) often face challenges such as optimizing sample preparation, handling large datasets, and troubleshooting instrument issues. Mastering the intricacies of sample vitrification and grid preparation is crucial, as poor samples can hinder data collection. Additionally, managing and processing extensive datasets requires familiarity with specialized software and computational resources. Collaborating closely with experienced lab members, attending relevant workshops, and staying updated with the latest protocols can help overcome these challenges and accelerate research progress.

What is a Cryo-EM postdoctoral position?

A Cryo-EM postdoctoral position is a research-focused role for individuals who have recently earned a Ph.D. and want to gain advanced experience using cryo-electron microscopy (Cryo-EM). These postdocs work in academic or research institutions to study the structure of biological molecules at near-atomic resolution. Responsibilities typically include sample preparation, data collection, image processing, and structural analysis. The goal is to contribute to scientific discoveries in fields such as structural biology, biochemistry, and drug development.
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Post Doctoral Scholar

Post Doctoral Scholar

The Ohio State University

Columbus, OH • On-site

Full-time

Posted 19 days ago

Job description

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Job Title:
Post Doctoral Scholar
Department:
Veterinary Medicine | Veterinary Biosciences
The Xu Lab at the Center for Retrovirus Research in The Ohio State University is seeking a highly driven Postdoctoral Scholar (recent PhD) with demonstrated expertise in cryo-electron microscopy and/or X-ray crystallography and a strong publication record. Our research focuses on uncovering the molecular mechanisms governing glycoprotein conformational dynamics and antibody-antigen interactions in cancer and viral diseases, with the goal of advancing therapeutic and vaccine design. The successful candidate will lead structure-based studies of glycoproteins, antibodies, and their complexes, taking projects from protein production through high-resolution structure determination and mechanistic interpretation. This role requires a hands-on, detail-oriented scientist who can execute efficiently, troubleshoot independently, and consistently deliver high-quality, publication-ready results. The postdoc will work in a fast-paced, collaborative environment, contribute to high-impact manuscripts and grant efforts, and have the opportunity to develop independent research directions. We are looking for individuals with a strong work ethic, intellectual curiosity, and a proven track record of productivity who are eager to tackle challenging and impactful problems in structural biology and translational science.
Additional Information:
MINIMUM QUALIFICATIONS AND EDUCATION:
Recent Ph.D. graduate in Structural Biology field. Demonstrated expertise in cryo-electron microscopy (cryo-EM) and/or X-ray crystallography, supported by a strong publication record in peer-reviewed journals. Proven hands-on experience in recombinant protein expression and purification, and structural analysis of macromolecular complexes. Ability to work independently with a high level of rigor and responsibility, while contributing effectively in a collaborative, multidisciplinary team environment. Excellent written and oral communication skills, with a strong record of scientific productivity.
DESIRED QUALIFICATIONS AND EDUCATION:
Skillful with cryo-EM data processing and structural refinement software (e.g., cryoSPARC, RELION, Phenix, Coot). Expertise in computational modeling and structure-based protein engineering. Strong interest in AI-based protein design approaches. Prior research experience in glycoproteins and antibody-antigen interactions. Experience with membrane protein expression and purification, including reconstitution in nanodiscs (preferred but not required).
WORKING CONDITIONS:
This position will be based in a research laboratory environment with standard laboratory conditions. Must be able to work at a computer for extended periods for data analysis, molecular modeling, and manuscript preparation. May require occasional work with biological samples, including recombinant proteins and antibodies. Use of specialized equipment such as FPLC, BLI and cryo-EM sample preparation instruments. Adherence to safety protocols for handling biological and chemical reagents. Occasional evening or weekend work may be required based on experimental timelines.
Location:
Goss Laboratory (0180)
Position Type:
Term (Fixed Term)
Scheduled Hours:
40
Shift:
First Shift
Final candidates are subject to successful completion of a background check. A drug screen or physical may be required during the post offer process.
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