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Cryo Em Postdoctoral Position Jobs in Ohio (NOW HIRING)

Ohio State University

Post Doctoral Scholar

Columbus, OH · On-site

$47K - $64K/yr

... cryo-EM. The postdoc will receive training from current lab members in culturing insect and mammalian cells as well as in protein and RNA purification methods. The position also requires ...

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Cryo Em Postdoctoral Position information

What is a Cryo-EM postdoctoral position?

A Cryo-EM postdoctoral position is a research-focused role for individuals who have recently earned a Ph.D. and want to gain advanced experience using cryo-electron microscopy (Cryo-EM). These postdocs work in academic or research institutions to study the structure of biological molecules at near-atomic resolution. Responsibilities typically include sample preparation, data collection, image processing, and structural analysis. The goal is to contribute to scientific discoveries in fields such as structural biology, biochemistry, and drug development.

What are the key skills and qualifications needed to thrive as a Cryo-EM postdoctoral researcher?

To thrive as a Cryo-EM Postdoctoral Researcher, you need advanced knowledge in structural biology, electron microscopy techniques, and a PhD in a relevant field such as biochemistry or biophysics. Expertise in using cryo-electron microscopes, image processing software (e.g., RELION, CryoSPARC), and data analysis pipelines is typically required. Strong problem-solving abilities, attention to detail, and effective communication skills distinguish top candidates in this role. These qualifications are crucial for conducting high-quality research, collaborating across multidisciplinary teams, and advancing structural biology discoveries.

What are some common challenges faced by postdoctoral researchers working with Cryo-EM, and how can they be addressed?

Postdoctoral researchers in Cryo-Electron Microscopy (Cryo-EM) often face challenges such as optimizing sample preparation, handling large datasets, and troubleshooting instrument issues. Mastering the intricacies of sample vitrification and grid preparation is crucial, as poor samples can hinder data collection. Additionally, managing and processing extensive datasets requires familiarity with specialized software and computational resources. Collaborating closely with experienced lab members, attending relevant workshops, and staying updated with the latest protocols can help overcome these challenges and accelerate research progress.

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Cryo Em Postdoctoral Position jobs near you
Infographic showing various Cryo Em Postdoctoral Position job openings in Ohio as of August 2026, with employment types broken down into 1% As Needed, 84% Full Time, 13% Part Time, and 2% Contract. Highlights an 88% Physical, 2% Hybrid, and 10% Remote job distribution.

Postdoctoral Scholar, Department of Physiology & Biophysics

Case Western Reserve University

Cleveland, OH • On-site

$55K - $62K/yr

Full-time

Medical, Life

Posted 4 days ago

Case Western Reserve University rating

8.9

Company rating: 8.9 out of 10

Based on 22 frontline employees who took The Breakroom Quiz

34th of 622 rated colleges and universities

Job description

Description
The Zhu Lab in the Department of Physiology & Biophysics at Case Western Reserve University is seeking a qualified candidate to fill a postdoctoral scholar position. This is a one-year appointment with the possibility of renewal for additonal years, contingent upon satisfactory performance and continued funding. The candidate will investigate host defense mechansms and pathogen adaptation within host cells using cutting-edge cryo-electron tomography (cryo-ET) techniques in conjunction with cryo-correlative light and electron microscopy (cryo-CLEM) and cryo-focused ion beam/scanning electron microscopy (cryo-FIB/SEM).
This position focuses on elucidating the structural mechanisms of GBP1 (Guanylate Binding Protein 1), a critical interferon-induced immune protein that recognizes and destroys diverse intracellular bacterial pathogens. This postdoctoral fellow will visualize critical biological processes underlying host cell defense against microbial threats using state-of-the-art cryo-ET, and will contribute to developing novel in situ imaging methods for studying host-pathogen interactions at molecular resolution.
Other duties and responsibilities include:
  • Design and execute in vitro reconstitution experiments to investigate GBP1 targeting of pathogen surfaces, including protein purification, mutagenesis, and biochemical characterization.
  • Perform cryo-ET sample preparation and data collection, including plunge-freezing, cryo-FIB/SEM lamella millling, and tilt series acquisiton on the Titan Krios cryo-electron microscope.
  • Conduct cryo-CLEM to identify and target biological structures of interest, correlating flourescence signals with high-resolution ultrastructural data in both ex situ and in situ contexts.
  • Analyze cryo-ET datasets, including tomogram reconstruction, subtomogram averaging, and 3D structure determination, to elucidate GBP1 structural mechanisms during pathogen recognition and organelle interactions.
  • Perform mammaliam cell culture, genetic manipulation, and bacterial infection assays to generate cellular models for structural studies.

Qualifications
Ph.D. in Structural Biology, Biochemistry, Cell Biology, Microbiology, Immunology, or a related field. Experience with cryo-electron microscopy is preferred but not required; candidates with strong backgrounds in structural biology, biochemistry, or molecular/cell biology and a demonstrated interest in learning cryo-EM techniques will also be considered.
Candidates should have at least one peer reviewed publication. Ability to work independently and collaboratively in a multidisciplinary research environment.
In compliance with the City of Cleveland's Pay transparency Ordinance (effective October 27, 2025) the annual starting base salary range for this position is $55,000-$62,652. CWRU considers actors such as (but not limited to) the specific grant funding and the terms of research gant when extending an offer. Postdocs receive individual and family healthcare benefits, life insurance and employee assistance.
Application Instructions
Apply through nterfolio only
https://apply.interfolio.com/191863

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