Company Overview
Founded over a decade ago, CRISPR Therapeutics is a biopharmaceutical company that develops gene-based medicines for serious human diseases. It has advanced from a research-stage organization to a leader in the field, with the first CRISPR-based therapy approved for sickle cell disease and transfusionโdependent beta thalassemia. The companyโs pipeline spans hemoglobinopathies, cardiovascular, autoimmune, oncology, regenerative medicine and rare diseases. CRISPR Therapeutics is headquartered in Zug, Switzerland, with U.S. operations in Boston and San Francisco.
Position Summary
Senior Engineer II โ Nonโviral delivery technical development. Lead the design, optimization, and scaleโup of manufacturing processes for gene editing mRNA therapeutics. Bridge research innovation and clinical development, leveraging expertise in nucleic acid chemistry, enzymatic reactions and purification.
Responsibilities
- Lead the development, optimization, and scaleโup of upstream and downstream unit operations for mRNA drug substance.
- Apply Design of Experiments (DoE) and statistical analysis to evaluate process parameters, improve yields and ensure consistent product quality attributes.
- Drive tech transfer of developed processes to internal clinical manufacturing teams or external CDMOs.
- Author clear, comprehensive technical reports, SOPs, batch records, and tech transfer documentation.
- Provide onโfloor technical support and troubleshooting during scaleโup and GMP manufacturing runs.
- Partner with analytical development to correlate process changes with mRNA quality attributes.
- Mentor, coach and guide research associates and engineers, fostering a collaborative and highโperforming laboratory culture.
- Represent the technical development function in crossโfunctional project teams and present data to senior leadership.
Minimum Qualifications
- Ph.D. in Chemical Engineering, Bioengineering, Biochemistry, or a related discipline with 2โ4ยฝ+ years of industry experience; or
- NonโPh.D. and 10โ12 years of relevant experience.
- Core mRNA expertise: handsโon deep experience in in vitro transcription (IVT) kinetics and plasmid DNA linearization.
- Downstream purification: extensive experience with Tangential Flow Filtration and chromatography modes (Affinity, IEX, RPโHPLC).
- Equipment proficiency: operating automated chromatography systems such as รKTA Avant/Pure and filtration skids.
- Data analysis: proficiency with statistical software (JMP, Minitab) for DoE design and data analysis.
- Strong collaboration, ownership mindset, results orientation and an entrepreneurial spirit.
Preferred Qualifications
- Experience with mRNAโLNP formulation.
- Familiarity with GMP regulations, Quality by Design principles, and preparing regulatory filing documentation.
- Prior experience managing or directly mentoring junior researchers.
Compensation
Base pay range of $140,000 to $150,000+; bonus, equity and benefits available. Pay determined by jobโrelated factors.
Equal Employment Opportunity Statement
CRISPR Therapeutics, Inc. is committed to equal employment opportunity and nonโdiscrimination for all employees and qualified applicants without regard to race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.
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