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Crispr Scientist Jobs (NOW HIRING)

Crispr Therapeutics

Senior Manager, Drug Safety

Boston, MA · On-site

$140K - $155K/yr

CRISPR Therapeuticsis advancing a broad and diversified pipeline across hemoglobinopathies ... Bachelor's degree in life sciences, nursing, pharmacy, or related healthcare profession with 10+ ...

LanceSoft, Inc.

Senior Scientist

Ridgefield, CT

$91K - $124K/yr

Scientist III Location: Ridgefield, CT 06877 Duration:12 Months Note ... Must have 2 years of Crispr experience. * Molecular biology, qPCR, western blot. Proficiency in ...

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Crispr Scientist information

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$50.5K

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$174K

How much do crispr scientist jobs pay per year?

As of Jun 16, 2026, the average yearly pay for crispr scientist in the United States is $130,117.00, according to ZipRecruiter salary data. Most workers in this role earn between $107,500.00 and $173,000.00 per year, depending on experience, location, and employer.

What does a CRISPR scientist do?

A CRISPR scientist researches and develops applications using CRISPR gene-editing technology. Their work involves designing experiments to modify genetic material in cells or organisms, analyzing results, and ensuring the accuracy and safety of genetic edits. CRISPR scientists may work in academic, medical, or biotechnology settings, contributing to advancements in medicine, agriculture, and biological research. They often collaborate with other scientists to explore new therapeutic approaches or improve crop traits.

How to become a CRISPR scientist?

To become a CRISPR scientist, typically a strong educational background in molecular biology, genetics, or a related field is required, often including a Ph.D. or master's degree. Gaining experience with gene editing techniques, laboratory skills, and familiarity with CRISPR tools and protocols is essential, along with staying updated on recent research developments.

What are some common challenges faced by a CRISPR Scientist when designing gene-editing experiments?

CRISPR Scientists often encounter challenges such as minimizing off-target effects, optimizing guide RNA design, and ensuring efficient delivery of editing components to target cells. Additionally, troubleshooting unexpected cellular responses and verifying precise genome edits can be time-consuming and require meticulous planning. Collaboration with bioinformaticians and molecular biologists is usually essential to overcome these obstacles and achieve robust, reproducible results.

What careers work with CRISPR?

Careers that work with CRISPR include CRISPR scientists, molecular biologists, genetic engineers, and bioinformatics specialists. These roles involve developing gene editing techniques, conducting research, and applying CRISPR technology in areas like medicine, agriculture, and biotechnology, often requiring laboratory skills and knowledge of genetics and molecular biology.

How much does a CRISPR scientist make?

A CRISPR scientist's salary varies based on experience, education, and location, but typically ranges from $70,000 to $130,000 annually. Senior roles or those with specialized skills in gene editing and molecular biology can earn higher salaries, especially in biotech or pharmaceutical industries.

What are the key skills and qualifications needed to thrive as a CRISPR Scientist, and why are they important?

To thrive as a CRISPR Scientist, you need a strong background in molecular biology, genetics, and genome editing, typically supported by an advanced degree such as a PhD in a relevant field. Familiarity with CRISPR-Cas9 technologies, gene editing software, cell culture techniques, and laboratory information management systems (LIMS) is essential. Attention to detail, critical thinking, and effective collaboration are crucial soft skills for designing experiments and interpreting complex data. These competencies are vital for advancing precise gene-editing research and ensuring rigorous, reproducible scientific outcomes.

How much do CRISPR technicians make?

CRISPR technicians typically earn between $50,000 and $80,000 annually, depending on experience, education, and location. Entry-level roles may start lower, while experienced professionals with specialized skills in gene editing and laboratory techniques can earn higher salaries.

What is the difference between Crispr Scientist vs Gene Editing Researcher?

AspectCrispr ScientistGene Editing Researcher
CredentialsAdvanced degrees in molecular biology, genetics, or related fields; experience with CRISPR technologySimilar credentials; expertise in gene editing techniques, including CRISPR
Work EnvironmentLaboratories focused on genetic modification, biotech companies, research institutionsResearch labs, biotech firms, academic settings
Industry UsagePrimarily in biotech, pharmaceuticals, agriculture, and researchSimilar industries, often overlapping in research projects

Both roles involve genetic modification techniques, with a focus on CRISPR technology. A Crispr Scientist specializes specifically in CRISPR-based methods, while a Gene Editing Researcher may work with various gene editing tools, including but not limited to CRISPR. The roles often overlap in credentials and work environment, but the Crispr Scientist emphasizes expertise in CRISPR technology.

More about Crispr Scientist jobs
What cities are hiring for Crispr Scientist jobs? Cities with the most Crispr Scientist job openings:
What states have the most Crispr Scientist jobs? States with the most job openings for Crispr Scientist jobs include:
What job categories do people searching Crispr Scientist jobs look for? The top searched job categories for Crispr Scientist jobs are:
Crispr Scientist jobs near you
Infographic showing various Crispr Scientist job openings in the United States as of June 2026, with employment types broken down into 9% As Needed, 18% Full Time, 46% Part Time, and 27% Contract. Highlights an 64% Physical, 1% Hybrid, and 35% Remote job distribution, with an average salary of $130,117 per year, or $62.6 per hour.

Scientist II - Sr. Scientist, CRISPR Specificity & Genomic Safety

Profluent

Emeryville, CA • On-site

$40.75 - $51.25/hr

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 13 days ago

Job description

Profluent is an AI-first protein design company. Founded in 2022, we develop deep generative models to design and validate novel, functional proteins to revolutionize biomedicine. Based in Emeryville, CA, we are backed by leading investors including Altimeter Capital, Bezos Expeditions, Spark Capital, Insight Partners, Air Street Capital, AIX Ventures, and Convergent Ventures, and have raised over $150M to date.
Profluent is seeking a creative and enthusiastic Scientist II - Sr. Scientist to build and apply experimental workflows that characterize the specificity, safety, and developability of our personalized CRISPR base editing platform. This role will initially focus on establishing and scaling base-editor specificity workflows, including biochemical and cell-based approaches such as CHANGE-seq-BE and related methods for identifying DNA and RNA off-target activity. In the longer term, the candidate will spearhead off-target assessments for novel gene editing platforms such as engineered recombinases.
The candidate will work closely with protein engineering, cell biology, bioinformatics, automation, and program teams to generate decision-quality datasets that guide editor design, candidate selection, and therapeutic program development. This person will be responsible for benchmarking assays, interpreting NGS-based specificity data, identifying limitations and opportunities across methods, and building robust workflows that can be deployed across editing modalities and disease-relevant contexts.
This is an excellent opportunity to shape how AI-designed genome editing systems are evaluated and advanced, and to work cross-functionally with a diverse team of experts across machine learning, protein engineering, cell biology, genomics, and gene editing.
Responsibilities
  • Build and lead Profluent's strategy for base editor specificity assessment, with an emphasis on base-editor-relevant off-target discovery and validation workflows such as CHANGE-Seq-BE and related biochemical, cell-based, and targeted sequencing approaches
  • Develop, optimize, benchmark, and apply orthogonal methods to evaluate editing specificity, including workflows for base editors, nucleases, and broader genomic integrity assessment across relevant experimental systems
  • Design and execute studies to identify, prioritize, and validate potential off-target editing events, integrating assay development, NGS library preparation, sequencing QC, and data interpretation in partnership with computational biology and program teams
  • Generate high-quality, decision-enabling datasets that inform editor engineering, guide/editor selection, delivery conditions, candidate nomination, and program development strategy
  • Collaborate cross-functionally with protein engineering, cell biology, gene editing, bioinformatics, automation, and program teams to integrate specificity workflows into Profluent's broader R&D infrastructure
  • Establish robust experimental processes, documentation, and analysis frameworks to support reproducibility, scalability, assay qualification, and potential regulatory-facing genomic safety packages
  • Present results and clearly communicate experimental strategy, timelines, risks, milestones, and program implications to diverse scientific and company stakeholders
  • Provide mentorship and guidance to junior team members and peers, helping align goals, troubleshoot experiments, and maintain high standards for execution and interpretation
  • Stay current with emerging technologies in CRISPR specificity, base editing, off-target discovery, targeted validation, genomic integrity assessment, and therapeutic genome editing

Qualifications
  • PhD (or equivalent) in molecular biology, genomics, genome editing, biochemistry, bioengineering, genetics, chemical biology, or a related field with 2-4 years of relevant industry experience in genome editing specificity and genomic safety assessment
  • Deep expertise and hands-on experience with CRISPR-based genome editing systems, particularly base editors, and a strong understanding of modality-specific specificity risks such as DNA off-target editing, RNA off-target editing, bystander editing, indels, and unintended editing outcomes
  • Hands-on experience developing, optimizing, or applying NGS-based workflows for genome editing analysis, such as CHANGE-seq, CHANGE-seq-BE, GUIDE-seq, SITE-seq, CIRCLE-seq, Digenome-seq, DISCOVER-seq, INDUCE-seq, targeted amplicon sequencing, rhAmpSeq/AmpSeq-like workflows, hybrid capture, RNA-seq, WGS, or related approaches
  • Strong experimental background in molecular biology, mammalian cell culture, genome editing reagent delivery, NGS library preparation, assay troubleshooting, and quantitative analysis of editing outcomes
  • Experience interpreting complex sequencing datasets and collaborating with bioinformatics or computational biology teams to analyze off-target discovery, targeted validation, variant calling, RNA editing, indel profiles, or genomic integrity data
  • Ability to design rigorous experiments with appropriate controls, replicates, sensitivity considerations, and clear decision criteria
  • Experience with high-throughput or semi-automated workflows, process development, assay qualification, data tracking, and reproducible execution in a fast-paced research environment
  • High level of attention to detail and commitment to generating high-quality, decision-enabling data
  • Experience with cross-functional collaboration in a biotechnology setting, particularly with protein engineering, cell biology, computational biology, translational, or program teams
  • Excellent communication skills and ability to present complex scientific concepts, datasets, limitations, and recommendations to colleagues and stakeholders
  • Strong track record of managing complex projects, mentoring junior scientists, and driving workstreams from exploratory development through implementation

Preferences
  • Experience with therapeutic genome editing programs and genomic safety packages for candidate nomination, IND-enabling studies, or regulatory-facing documentation
  • Experience working with disease-relevant primary cells, ex vivo edited cells, iPSC-derived systems, or other therapeutically relevant model systems
  • Familiarity with ML-guided enzyme engineering campaigns and how specificity datasets can inform editor design, model evaluation, and candidate prioritization
  • Expertise in protein purification of genome editors for use in biochemical off-target assays

What We Offer
  • High-growth opportunity with meaningful impact on the future of protein design
  • Competitive compensation package with equity participation
  • 401(k) with a strong employer match
  • Comprehensive benefits including health/dental/vision insurance
  • Generous PTO policy and commitment to work-life balance
  • Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.
Work Authorization Requirement
Applicants must have ongoing work authorization in the United States that does not require employer sponsorship. Sponsorship will not be provided now or at any time in the future for this position.
Employment Eligibility Verification
Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.
Hiring Salary Range
$147,000-$177,000 USD

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