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Controlled Substance Compliance information

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$43K

$106.7K

$159.5K

How much do controlled substance compliance jobs pay per year?

As of Sep 3, 2026, the average yearly pay for controlled substance compliance in the United States is $106,734.00, according to ZipRecruiter salary data. Most workers in this role earn between $88,000.00 and $124,000.00 per year, depending on experience, location, and employer.

What is controlled substance compliance?

Controlled Substance Compliance refers to the processes and regulations that organizations must follow to legally handle, store, distribute, and dispose of controlled substances. This includes adhering to federal, state, and local laws, such as those enforced by the Drug Enforcement Administration (DEA). Compliance professionals ensure that all documentation, tracking, and security measures are in place to prevent diversion or misuse of these substances. They also conduct audits, provide employee training, and respond to regulatory inspections to maintain legal and ethical standards.

What are the main challenges faced in a controlled substance compliance role, and how can they be addressed?

Professionals in Controlled Substance Compliance often face challenges such as keeping up with frequently changing regulations, ensuring accurate record-keeping, and managing audits by regulatory agencies like the DEA. To address these, it's crucial to stay updated on current laws, implement robust compliance training programs, and utilize secure tracking systems for inventory and documentation. Regular internal audits and close collaboration with departments like pharmacy, legal, and security can further strengthen compliance and reduce the risk of violations.

What are the key skills and qualifications needed to thrive in controlled substance compliance, and why are they important?

To thrive in Controlled Substance Compliance, you need a strong understanding of regulatory requirements, risk management, and pharmaceutical or healthcare compliance, often supported by a degree in pharmacy, healthcare, or a related field. Familiarity with DEA guidelines, compliance management systems, and audit software is typically required, and certifications such as Certified Compliance & Ethics Professional (CCEP) are advantageous. Attention to detail, analytical thinking, and effective communication are vital soft skills for ensuring accurate record-keeping and successful collaboration across departments. These skills and qualities are essential to prevent regulatory violations, safeguard public safety, and maintain organizational integrity.

What is the difference between Controlled Substance Compliance vs Pharmacist?

AspectControlled Substance CompliancePharmacist
Required CredentialsRegulatory training, certifications in compliance and DEA regulationsDoctor of Pharmacy (PharmD), state licensure
Work EnvironmentRegulatory agencies, pharmaceutical companies, healthcare facilitiesCommunity pharmacies, hospitals, clinics
Industry UsageEnsures legal and regulatory adherence for controlled substancesDispenses medications, patient counseling, medication management

Controlled Substance Compliance professionals focus on regulatory adherence and DEA regulations related to controlled substances, often working in compliance departments or regulatory agencies. Pharmacists, on the other hand, are licensed healthcare providers responsible for dispensing medications and patient care. While both roles involve controlled substances, compliance specialists ensure legal adherence, whereas pharmacists handle medication management and patient interactions.

More about Controlled Substance Compliance jobs

What cities are hiring for Controlled Substance Compliance jobs?

Cities with the most Controlled Substance Compliance job openings:

What states have the most Controlled Substance Compliance jobs?

States with the most job openings for Controlled Substance Compliance jobs include:

What job categories do people searching Controlled Substance Compliance jobs look for?

The top searched job categories for Controlled Substance Compliance jobs are:

Controlled Substance Compliance jobs near you
Infographic showing various Controlled Substance Compliance job openings in the United States as of August 2026, with employment types broken down into 82% Full Time, and 18% Part Time. Highlights an 94% In-person, and 6% Remote job distribution, with an average salary of $106,734 per year, or $51.3 per hour.

Sr. Analyst, Controlled Substance Data systems

McKesson

Shepherdsville, KY • Hybrid

$80K - $101K/yr

Full-time

Posted 21 days ago

McKesson rating

7.9

Company rating: 7.9 out of 10

Based on 210 frontline employees who took The Breakroom Quiz

46th of 86 rated pharmaceutical

Job description

McKesson is an impact-driven, Fortune 10 company that touches virtually every aspect of healthcare. We are known for delivering insights, products, and services that make quality care more accessible and affordable. Here, we focus on the health, happiness, and well-being of you and those we serve - we care.

What you do at McKesson matters. We foster a culture where you can grow, make an impact, and are empowered to bring new ideas. Together, we thrive as we shape the future of health for patients, our communities, and our people. If you want to be part of tomorrow's health today, we want to hear from you.

The Senior Analyst, Controlled Substance Data Systems serves as the business owner and subject matter expert for systems and data that support McKesson's controlled substance compliance program. This role ensures the integrity, effectiveness, and regulatory defensibility of critical compliance platforms used to monitor controlled substance activity, identify risk, support investigations, and meet DEA requirements.

Working closely with Compliance, IT, Legal, Quality, and Operations, this individual translates regulatory requirements into business processes, system controls, reporting, and monitoring methodologies that support a risk-based compliance program.

This is a highly visible individual contributor role requiring strong analytical skills, regulatory judgment, and the ability to influence cross-functional stakeholders in a complex, regulated environment.


Key Responsibilities

Compliance Systems Ownership

  • Serve as business owner for controlled substance compliance systems and monitoring platforms.

  • Ensure systems, workflows, controls, and reporting capabilities align with DEA requirements and internal policies.

  • Partner with IT to define requirements, support testing, validate enhancements, and implement system improvements.

Regulatory Compliance & Risk Monitoring

  • Translate regulatory requirements and enforcement expectations into monitoring logic, business rules, workflows, and reports.

  • Support suspicious order monitoring, customer due diligence, ordering threshold management, and other risk-based controls.

  • Identify compliance risks, emerging trends, and opportunities to strengthen program effectiveness.

Data Governance & Audit Readiness

  • Maintain the accuracy, integrity, traceability, and audit readiness of controlled substance data.

  • Conduct data validation, reconciliation, and quality reviews across compliance datasets.

  • Support regulatory inspections, audits, investigations, and enforcement inquiries through data analysis and documentation.

Investigations & Regulatory Events

  • Support investigations related to theft, loss, diversion, and other controlled substance compliance events.

  • Analyze data, identify trends, and contribute to root cause analysis and corrective actions.

  • Maintain documentation and audit trails supporting regulatory reporting and filings.

Cross-Functional Partnership

  • Collaborate with Compliance, Legal, Quality, Operations, and Technology teams to resolve issues and implement solutions.

  • Provide guidance and subject matter expertise on compliance systems, reporting, and data interpretation.

  • Support continuous improvement initiatives that enhance compliance effectiveness, scalability, and operational efficiency.

THIS ROLE WILL REQUIRE BEING ONSITE AT LEAST 2 DAYS A WEEK AT THE SHEPHERDSVILLE, KY OR MASON, OH FACILITY

Weare unable to provide sponsorship for this role presnetly or in the future.

Minimum Qualifications

  • Bachelor's degree in Information Systems, Data Analytics, Business, Regulatory Affairs, Healthcare Administration, or a related field.

  • 7+ years of experience supporting compliance, regulatory, quality, risk, or data-driven systems within a regulated industry.

  • Experience owning or supporting business-critical systems, applications, or compliance platforms.

  • Strong analytical, problem-solving, and documentation skills.

  • Experience supporting audits, inspections, investigations, or regulatory reviews.

  • Experience partnering with technology teams on system enhancements, implementations, testing, or validation activities.

  • Ability to operate independently and influence stakeholders across multiple functions.


Preferred Qualifications

  • Experience supporting controlled substance compliance programs.

  • Knowledge of DEA regulations, suspicious order monitoring, customer due diligence, diversion prevention, or related compliance controls.

  • Experience within pharmaceutical distribution, healthcare, life sciences, manufacturing, logistics, or other highly regulated industries.

  • Experience with compliance monitoring platforms, risk management systems, data governance, or regulatory reporting tools.

  • Advanced data analysis and reporting capabilities.


We are proud to offer a competitive compensation package at McKesson as part of our Total Rewards. This is determined by several factors, including performance, experience and skills, equity, regular job market evaluations, and geographical markets. The pay range shown below is aligned with McKesson's pay philosophy, and pay will always be compliant with any applicable regulations. In addition to base pay, other compensation, such as an annual bonus or long-term incentive opportunities may be offered. For more information regarding benefits at McKesson, pleaseclick here.

Our Base Pay Range for this position

$96,900 - $161,500

McKesson has become aware of online recruiting-related scams in which individuals who are not affiliated with or authorized by McKesson are using McKesson's (or affiliated entities, like CoverMyMeds or RxCrossroads) name in fraudulent emails, job postings or social media messages. In light of these scams, please bear the following in mind:
McKesson Talent Advisors will never solicit money or credit card information in connection with a McKesson job application.


McKesson Talent Advisors do not communicate with candidates via online chatrooms or using email accounts such as Gmail or Hotmail. Note that McKesson does rely on a virtual assistant (Gia) for certain recruiting-related communications with candidates.

McKesson job postings are posted on our career site: careers.mckesson.com.

McKesson is an Equal Opportunity Employer

McKesson provides equal employment opportunities to applicants and employees, without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, age, genetic information, or any other legally protected category. For additional information on McKesson's full Equal Employment Opportunity policies, visit our Equal Employment Opportunity page.

McKesson is committed to being an Equal Employment Opportunity Employer and offers opportunities to all job seekers including job seekers with disabilities. If you need a reasonable accommodation to assist with your job search or application for employment, please contact us by sending an email to (United States) Disability_Accommodation@McKesson.com or (Canada) Accessibility@mckesson.ca. Resumes or CVs submitted to this email box will not be accepted.

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