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Contract Method Validation Jobs in Philadelphia, PA

Ott Scientific

Senior Analytical Chemist

Warrington, PA · On-site

$87K - $106K/yr

Polysciences technical operations and scientific laboratories offer custom synthesis, contract ... Other responsibilities also include: execution of method validations or verifications, drafting of ...

Frontage Laboratories

Associate Scientist

Exton, PA · On-site

... Contract Research Organization operating over 25 state-of-the-art laboratories across the US ... The successful candidate will support bioanalytical method development, validation, and sample ...

Frontage Laboratories

Scientist Senior

Exton, PA · On-site

$88K - $120K/yr

Exton, PA Full-time Frontage Laboratories Inc. is an award winning, full-service, CRO/Contract ... Conduct analytical method development and validation for drug substance and drug product. * Draft ...

TriSearch

QC Chemist

Philadelphia, PA

... contract development and manufacturing organization (CDMO) located in the Horsham, Pennsylvania ... Execute method development, method transfer, validation, and analytical troubleshooting activities.

Frontage Laboratories

Scientist

Exton, PA · On-site

Exton, PA Frontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research ... The scientist's duties include analytical method development/method validation, protocol/report ...

Pharmaron

Software Validation Senior Associate

Exton, PA · On-site

$75K - $85K/yr

Exton, PA (Onsite) About Pharmaron Pharmaron is a global contract research and manufacturing ... Risk-based validation methodologies * GxP compliance requirements * Quality Systems and Change ...

Ott Scientific

Quality Control Lead

Warrington, PA · On-site

$87K - $106K/yr

Polysciences technical operations and scientific laboratories offer custom synthesis, contract ... Strong knowledge of analytical equipment, analytical methods, method validation and data analysis ...

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All JobsContract Method Validation JobsContract Method Validation Jobs in Philadelphia, PA

Contract Method Validation information

See Philadelphia, PA salary details

$22

$52

$78

How much do contract method validation jobs pay per hour?

As of Aug 16, 2026, the average hourly pay for contract method validation in Philadelphia, PA is $52.47, according to ZipRecruiter salary data. Most workers in this role earn between $39.76 and $63.80 per hour, depending on experience, location, and employer.

What is the difference between Contract Method Validation vs Analytical Method Validation?

AspectContract Method ValidationAnalytical Method Validation
PurposeValidates that a contracted method meets specific requirements for a particular project or clientEnsures an analytical method is accurate, reliable, and reproducible for testing purposes
ScopeTypically project-specific, focusing on methods used under contractual agreementsBroader, covering method development, validation, and routine testing
CredentialsOften requires validation expertise, GMP knowledge, and industry-specific certificationsRequires analytical chemistry knowledge, validation experience, and relevant certifications
Work EnvironmentPharmaceutical, biotech, or manufacturing settings with client-specific projectsLaboratories performing routine testing and method development in similar industries

Contract Method Validation focuses on validating methods for specific client projects, while Analytical Method Validation ensures the overall reliability of testing methods used routinely in laboratories. Both roles require similar credentials and work in related environments, but their scope and purpose differ.

What are the most commonly searched types of Method Validation jobs in Philadelphia, PA?

The most popular types of Method Validation jobs in Philadelphia, PA are:

What cities near Philadelphia, PA are hiring for Contract Method Validation jobs?

Cities near Philadelphia, PA with the most Contract Method Validation job openings:

Contract Method Validation jobs near you
Infographic showing various Contract Method Validation job openings in Philadelphia, PA as of August 2026, with employment types broken down into 89% Full Time, 3% Part Time, and 8% Contract. Highlights an 87% Physical, 4% Hybrid, and 9% Remote job distribution, with an average salary of $109,135 per year, or $52.5 per hour.

Senior Scientist - Method Development-Biomarker LC-MS/MS

Frontage Laboratories

Exton, PA • On-site

$88K - $120K/yr

Full-time

Medical, Dental, Life, Retirement

Re-posted 11 days ago

Job description

Senior Method development scientist-Biomarker LC-MS/MS

Title: Senior method development scientist- Biomarker LC-MS/MS

Location: 700 Pennsylvania Dr. Exton, PA

Reports to: SVP, Central Lab, Biomarker, and Biologics Services

Full-time/on-site


Frontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China. Our core competencies include drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials.


Position/Job Summary:

The Senior method development scientist supports method development using LC-MS/MS platform for large molecules (biomarkers, proteins, antibodies, ADCs, Oligonucleotides, etc). The senior method development scientist will be a member of the method development team, the responsibility includes serving as subject matter expert when new proposal is received, reviewing the client request and evaluating the feasibility of the project, developing the method after the contract is signed, transferring the developed method to the validation team, and troubleshooting for challenging method.


Roles & Responsibilities:

  • Develop method using LC-MS/MS platform for large molecules (Proteins, antibodies, ADC, Oligonucleotides, Liposomal drugs, biomarkers, etc) quantitation in biological matrices.
  • Facilitate the method transfer from the Method development team with the method validation team.
  • Communicate project timelines, status, and data to Principal Investigator effectively addressing any issues that may arise.
  • Ability to work on multiple projects at the same time.
  • Research literature and external sources and identify new techniques and procedures that strengthen Frontage’s capabilities.
  • Maintain the proper level of regulatory compliance. Ensure that GLP regulations and SOPs are followed in all bioanalytical service activities.
  • Help with training and/or mentoring of junior scientific staff.
  • Set-up, utilize, and maintain complex instrumentation Follow safety precautions.

Education, Experience & Skills Required:

  • Ph.D. or Master’s degree in Analytical Chemistry, Biochemistry, Biology or related scientific discipline.
  • 6-10 years of direct experience of bioanalytical method development for large molecules using LC-MS/MS in the biotech, pharma or CRO industry.
  • Demonstrated experience in mass-spectrometry method development for antibodies including LC-MS intact protein analysis, peptide mapping, conjugate analysis etc.
  • Demonstrated experience in small molecule and protein mass-spectrometry of quantitation of antibody drug-conjugates (ADC), including total Antibody, Conjugated payload, and free payload.
  • Experience with Oligonucleotides and liposomal drug quantitation using LC-MS/MS is a plus.
  • Proven ability to successfully work in a team environment. Excellent oral and written communication skills.
  • Good knowledge and application of GLP with the ability to train technical personnel.
  • Efficient time management.
  • Strong troubleshooting and analytical skills.
  • Detail oriented and meticulous.
  • Ability to work independently under time constraints.


Salary and Benefits:

Frontage Laboratories offers a competitive compensation and benefits package including health and dental insurance, a 401(k) plan, disability insurance, and life insurance.


Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, among other things, or status as a qualified individual with disability.