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Computational Software Developer Jobs in Missouri

Pfizer

Senior Computational Chemist

California, MO · On-site

$106 - $177/hr

... Engineering):* Lead the design, curation, and application of high-quality chemistry and ... Deliver robust, reusable, and well-documented scientific software aligned with modern best ...

Mastercard, Inc.

Lead Software Engineer

O Fallon, MO · On-site

... computational complexity, scalability, and system constraints • Guide teams in applying ... React, Angular • API design and tooling best practices • Cloud and DevOps: Kubernetes, Docker ...

MasterCard

Lead Software Engineer

O Fallon, MO · On-site

... on computational complexity, scalability, and system constraints Guide teams in applying ... React, Angular API design and tooling best practices Cloud and DevOps: Kubernetes, Docker, Pivotal ...

Socket.dev

Senior Algorithm Engineer

California, MO · On-site

$186 - $317/hr

This role offers the opportunity to work at the intersection of machine learning, computational imaging, software engineering, and semiconductor manufacturing. The ideal candidate will have deep ...

Socket.dev

Senior Software Engineer in Test

California, MO · On-site

$129 - $194/hr

Experience testing data-intensive, scientific, or computational analysis software * Familiarity ... Bachelor's degree or higher in Computer Science, Engineering, Bioinformatics, or a related field ...

Illumina

Senior Software Engineer in Test

California, MO · On-site

$129 - $194/hr

Experience testing data-intensive, scientific, or computational analysis software * Familiarity ... Bachelor's degree or higher in Computer Science, Engineering, Bioinformatics, or a related field ...

Varsity Tutors

Linear Algebra Tutor

Kansas City, MO · Remote

$18 - $40/hr

... data science, engineering, and advanced mathematics. * Conceptual Teaching & Problem-Solving ... Adapts instruction using matrix visualization tools, computational software like MATLAB or Python ...

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Computational Software Developer information

See Missouri salary details

$45K

$104.9K

$155.7K

How much do computational software developer jobs pay per year?

As of Aug 26, 2026, the average yearly pay for computational software developer in Missouri is $104,911.00, according to ZipRecruiter salary data. Most workers in this role earn between $84,400.00 and $121,900.00 per year, depending on experience, location, and employer.

What is a computational software developer?

A Computational Software Developer is a professional who designs, develops, and maintains software systems that perform complex mathematical, scientific, or engineering computations. They often work in fields such as scientific research, engineering, finance, and data analysis, creating tools that simulate processes, analyze data, or solve computational problems. These developers typically possess strong programming skills in languages like Python, C++, or MATLAB, and have a solid understanding of algorithms, mathematics, and domain-specific knowledge relevant to their projects.

What are the key skills and qualifications needed to thrive as a computational software developer, and why are they important?

To thrive as a Computational Software Developer, you need strong programming skills (often in languages like Python, C++, or Java), a solid understanding of algorithms, and typically a degree in computer science, mathematics, or a related field. Familiarity with computational libraries (such as NumPy, SciPy, or TensorFlow), version control systems like Git, and experience with high-performance or parallel computing are commonly required. Analytical thinking, problem-solving abilities, and effective teamwork are vital soft skills for excelling in this role. These skills and qualities enable developers to create robust, efficient computational solutions and collaborate effectively within multidisciplinary teams.

What are some common challenges faced by computational software developers, and how can they be addressed?

Computational Software Developers often encounter challenges such as optimizing code for high-performance computing, ensuring numerical accuracy, and integrating complex algorithms with existing systems. These challenges can be addressed by staying up-to-date with the latest computational techniques, collaborating closely with domain experts, and utilizing profiling tools to identify performance bottlenecks. Regular code reviews and testing are also essential to maintain reliability and foster knowledge sharing within multidisciplinary teams.

What are popular job titles related to Computational Software Developer jobs in Missouri?

For Computational Software Developer jobs in Missouri, the most frequently searched job titles are:

What job categories do people searching Computational Software Developer jobs in Missouri look for?

The top searched job categories for Computational Software Developer jobs in Missouri are:

Computational Software Developer jobs near you

Software Development Engineer, Senior Software Development Engineer - Agentic Systems, AI for D[...]

Jobtailor

California, MO • On-site

$120 - $180/hr

Other

Posted 8 days ago

Job description

  • Develop and maintain backend services, APIs, and user-facing applications for an agentic drug design platform.
  • Integrate machine learning models, scientific applications, databases, and internal services into reliable end-to-end workflows.
  • Implement agentic capabilities, including tool execution, workflow orchestration, state management, evaluation, and observability.
  • Build software that enables scientists to configure, run, inspect, and reproduce computational molecule design workflows.
  • Deploy models and scientific tools into secure, scalable, cloud-based production environments.
  • Write clean, maintainable, and well-tested code, and contribute to automated testing, documentation, code reviews, and CI/CD practices.
  • Monitor deployed services, troubleshoot issues, and improve platform reliability, performance, and usability.
  • Work closely with users to understand scientific needs, gather feedback, and translate requirements into practical software solutions.
  • Contribute to technical design decisions and the ongoing evolution of the platform’s architecture.
  • Develop familiarity with relevant drug discovery concepts and apply software engineering best practices in a scientific research environment.
Requirements
  • For the Software Engineer level, you have a bachelor’s or master’s degree in Computer Science, Software Engineering, or a related technical field, or equivalent practical experience, and 3+ years of professional software engineering experience.
  • For the Senior Software Engineer level, you have a bachelor’s or master’s degree in Computer Science, Software Engineering, or a related technical field, or equivalent practical experience, and 5+ years of professional software engineering experience.
  • You are proficient in Python and have strong software engineering fundamentals, including API design, automated testing, data modeling, and system design.
  • You have experience independently delivering production software from technical design and implementation through deployment, monitoring, and ongoing support.
  • You have built backend services, platform capabilities, developer tools, or user-facing applications in a cloud environment.
  • You are comfortable working with relational databases, asynchronous workflows, containers, version control, and CI/CD practices.
  • You can translate user and scientific needs into practical technical solutions and communicate effectively with engineers, researchers, product managers, and domain experts.
  • You are interested in AI-enabled applications and in integrating models, scientific tools, and data into reliable workflows.
  • You are motivated by delivering software to users and improving real scientific workflows.
Core Competencies

Proficient in Python with strong software engineering fundamentals, including API Design, Automated Testing, and System Design. Experienced in developing and maintaining backend services and integrating machine learning models into cloud-based production environments.

Highest-signal resume keywords
  • Python Programming
  • API Design
  • Automated Testing
  • Cloud Environment Development
  • Relational Database Management
ATS Optimization KeywordsHard Skills
  • Backend Service Development
  • Machine Learning Integration
  • Data Modeling
  • System Design
  • Workflow Orchestration
  • Code Review
  • CI/CD Practices
  • Tool Execution
  • State Management
  • Observability
Soft Skills
  • Effective Communication
  • User Needs Translation
  • Collaboration with Engineers
  • Feedback Gathering
Certifications & Qualifications
  • Bachelor's Degree in Computer Science
  • Master's Degree in Software Engineering
Industry Keywords
  • Drug Design
  • Scientific Applications
  • Computational Molecule Design
  • AI-Enabled Applications
  • Scientific Research Environment
Tools & Technologies
  • Cloud-Based Production Environments
  • Version Control
  • Containers
  • Asynchronous Workflows
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