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Computational Software Developer Jobs in Colorado

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Geophysicist 1

Englewood, CO · On-site

Our diverse service lines, including Water, Architecture, Building Engineering Services, Field ... Experience with Oasis montaj Geosoft Geophysical Data Analysis software and Matlab Computational ...

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Computational Software Developer information

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$50.5K

$117.6K

$174.6K

How much do computational software developer jobs pay per year?

As of Jun 21, 2026, the average yearly pay for computational software developer in Colorado is $117,607.00, according to ZipRecruiter salary data. Most workers in this role earn between $94,600.00 and $136,700.00 per year, depending on experience, location, and employer.

What is a Computational Software Developer?

A Computational Software Developer is a professional who designs, develops, and maintains software systems that perform complex mathematical, scientific, or engineering computations. They often work in fields such as scientific research, engineering, finance, and data analysis, creating tools that simulate processes, analyze data, or solve computational problems. These developers typically possess strong programming skills in languages like Python, C++, or MATLAB, and have a solid understanding of algorithms, mathematics, and domain-specific knowledge relevant to their projects.

What are the key skills and qualifications needed to thrive as a Computational Software Developer, and why are they important?

To thrive as a Computational Software Developer, you need strong programming skills (often in languages like Python, C++, or Java), a solid understanding of algorithms, and typically a degree in computer science, mathematics, or a related field. Familiarity with computational libraries (such as NumPy, SciPy, or TensorFlow), version control systems like Git, and experience with high-performance or parallel computing are commonly required. Analytical thinking, problem-solving abilities, and effective teamwork are vital soft skills for excelling in this role. These skills and qualities enable developers to create robust, efficient computational solutions and collaborate effectively within multidisciplinary teams.

What are some common challenges faced by Computational Software Developers, and how can they be addressed?

Computational Software Developers often encounter challenges such as optimizing code for high-performance computing, ensuring numerical accuracy, and integrating complex algorithms with existing systems. These challenges can be addressed by staying up-to-date with the latest computational techniques, collaborating closely with domain experts, and utilizing profiling tools to identify performance bottlenecks. Regular code reviews and testing are also essential to maintain reliability and foster knowledge sharing within multidisciplinary teams.
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Computational Software Developer jobs near you
Infographic showing various Computational Software Developer job openings in Colorado as of June 2026, with employment types broken down into 71% Full Time, 14% Temporary, and 15% Contract. Highlights an 100% In-person job distribution, with an average salary of $117,607 per year, or $56.5 per hour.
Principal Scientist, Computational Chemistry

Principal Scientist, Computational Chemistry

Cogent Biosciences

Boulder, CO • On-site

Other

Medical, Dental, Vision, Retirement, PTO

Posted 4 days ago

Job description

Who We Are:

Cogent Biosciences is a publicly traded biotechnology company focused on developing novel precision therapies to treat a broad range of patients with unmet medical needs. Cogent's lead program, bezuclastinib, is designed to selectively and potently inhibit exon 17 mutations found within the KIT receptor tyrosine kinase, including KIT D816V. KIT D816V is responsible for driving a rare and serious condition called Systemic Mastocytosis, and exon 17 mutations are also found in patients with gastrointestinal stromal tumors (GIST), a type of cancer with strong dependence on oncogenic KIT signaling. Bezuclastinib has exhibited promising initial data across all three trials: APEX in AdvSM, SUMMIT in NonAdvSM, and PEAK in GIST, including an encouraging safety profile across 600+ patients in single-agent and combination dosing. 

The Role: 

We are seeking an Experienced Computational Chemist who thrives at the intersection of molecular modeling, datadriven decision making, and innovative drug design. In this role, you will directly influence discovery programs by generating actionable structurebased insights, developing predictive models, and partnering with multidisciplinary teams to guide molecular design from hits to optimized leads. This is a full-time, on-site position based at our R&D facility in Boulder, Colorado.

Responsibilities:

  • Apply structurebased and ligandbased drug design methods-including docking, protein modeling, and a range of computational techniques-to support projects from hit discovery through lead optimization.
  • Collaborate with project team members, engaging them in iterative structurebased drug design cycles to generate hypotheses, evaluate targets, triage hits, and guide SAR exploration.
  • Present modeling insights clearly and effectively to crossfunctional project teams, ensuring data is interpreted in the right context.
  • Develop, refine, and maintain robust computational workflows on HPC Linux environments, enabling scalable execution of largescale simulations.
  • Train and mentor colleagues on computational chemistry tools, cheminformatics standards, data formats, and key workflow practices.

Qualifications:

  • Ph.D. in Computational Chemistry or a related field, with 3+ years of relevant industrial experience.
  • Expertise in structurebased design, docking, virtual screening, pharmacophore modeling, and other computational approaches for lead optimization.
  • Expertise in MOE modeling software, with working knowledge of other commercial and opensource computational chemistry platforms preferred.
  • Strong handson experience with cheminformatics platforms and tools, including Spotfire.
  • Strong programming skills with experience in building custom scripts or automated pipelines, is a plus.
  • Proficiency in Linux/UNIX, shell scripting, and HPC frameworks (e.g., SLURM, LSF, PBS/Torque).
  • Experience optimizing large computational workloads on cluster or cloud infrastructure.
  • Familiarity with molecular representations and cheminformatics standards (SMILES, SDF, descriptors, fragmentbased encodings).
  • A solid publication record and excellent scientific communication skills.
  • Proven effectiveness working within crossfunctional, datadriven scientific teams.

Salary Range:

$165k - 190k USD 

Target Bonus: 15%
Exact compensation will vary based on skills, experience, and location.
Our Locations

Waltham, MA: Our headquarters is located in the Greater Boston life sciences community, with an open, collaborative office environment designed to support teamwork and connection. Employees benefit from convenient on-site amenities, including free on-site parking and gym facilities in the building. 

Boulder, CO: Our Boulder location is home to Cogent's discovery research organization and a key scientific hub with strong leadership based on site. Situated in the greater Denver-Boulder biopharmaceutical corridor, this office plays a central role in advancing our discovery efforts and pipeline. 

Our Offer To You 

At Cogent Biosciences, we offer a competitive salary, bonus, and ongoing stock awards, alongside a benefits package that sets us apart. We cover 100% of medical, dental, and vision premiums for you and your family, and help reduce out-of-pocket costs by funding up to 75% of in-network deductibles. Our benefits also include a 401(k) match with immediate vesting, generous paid time off, 12 weeks of fully paid parental leave, paid family and medical leave for all employees regardless of location, and company-paid short-term disability coverage for up to 20 weeks. Additional perks like wellness programs, tuition reimbursement, and inclusive family-forming support help you thrive at work and beyond. 

We are proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce. We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability, or any other status protected under federal, state, or local law. All employment is decided on the basis of qualifications, merit, and business need. 

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