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Computational Software Developer Jobs in California

Cadence Design Systems, Inc.

Software Engineer

San Jose, CA · On-site

$186K - $253K/yr

... computational software company. * Analyze user needs and develop software solutions, applying ... Master's degree in Electrical Engineering, Computer Engineering, or related field * Minimum three ...

NewLimit

Computational Biologist

South San Francisco, CA · On-site

$150K - $200K/yr

Description NewLimit is seeking a Computational Biologist to join our Predict team. In this role ... Strong software engineering fundamentals and experience working with bioinformatics tools and ...

NewLimit

Computational Biologist

South San Francisco, CA · On-site

$150K - $200K/yr

Description NewLimit is seeking a Computational Biologist to join our Predict team. In this role ... Strong software engineering fundamentals and experience working with bioinformatics tools and ...

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Computational Software Developer information

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$47.4K

$110.4K

$163.8K

How much do computational software developer jobs pay per year?

As of Jul 14, 2026, the average yearly pay for computational software developer in California is $110,380.00, according to ZipRecruiter salary data. Most workers in this role earn between $88,800.00 and $128,300.00 per year, depending on experience, location, and employer.

What is a Computational Software Developer?

A Computational Software Developer is a professional who designs, develops, and maintains software systems that perform complex mathematical, scientific, or engineering computations. They often work in fields such as scientific research, engineering, finance, and data analysis, creating tools that simulate processes, analyze data, or solve computational problems. These developers typically possess strong programming skills in languages like Python, C++, or MATLAB, and have a solid understanding of algorithms, mathematics, and domain-specific knowledge relevant to their projects.

What are the key skills and qualifications needed to thrive as a Computational Software Developer, and why are they important?

To thrive as a Computational Software Developer, you need strong programming skills (often in languages like Python, C++, or Java), a solid understanding of algorithms, and typically a degree in computer science, mathematics, or a related field. Familiarity with computational libraries (such as NumPy, SciPy, or TensorFlow), version control systems like Git, and experience with high-performance or parallel computing are commonly required. Analytical thinking, problem-solving abilities, and effective teamwork are vital soft skills for excelling in this role. These skills and qualities enable developers to create robust, efficient computational solutions and collaborate effectively within multidisciplinary teams.

What are some common challenges faced by Computational Software Developers, and how can they be addressed?

Computational Software Developers often encounter challenges such as optimizing code for high-performance computing, ensuring numerical accuracy, and integrating complex algorithms with existing systems. These challenges can be addressed by staying up-to-date with the latest computational techniques, collaborating closely with domain experts, and utilizing profiling tools to identify performance bottlenecks. Regular code reviews and testing are also essential to maintain reliability and foster knowledge sharing within multidisciplinary teams.
What are popular job titles related to Computational Software Developer jobs in California? For Computational Software Developer jobs in California, the most frequently searched job titles are:
What job categories do people searching Computational Software Developer jobs in California look for? The top searched job categories for Computational Software Developer jobs in California are:
What cities in California are hiring for Computational Software Developer jobs? Cities in California with the most Computational Software Developer job openings:
Computational Software Developer jobs near you
Infographic showing various Computational Software Developer job openings in California as of July 2026, with employment types broken down into 100% Contract. Highlights an 100% In-person job distribution, with an average salary of $110,380 per year, or $53.1 per hour.
Computational Biologist

Computational Biologist

NewLimit

South San Francisco, CA • On-site

Full-time

Posted 10 days ago

Job description

Job Summary:
NewLimit is a biotechnology company working to radically extend human healthspan. They are seeking a Computational Biologist to develop and operate bioinformatics pipelines supporting large-scale single-cell perturbation screens, collaborating closely with experimentalists and computational scientists.
Responsibilities:
• Collaborate with Write, Read, and Predict teams to support the design, execution, and interpretation of experiments using single-cell and multi-omics data
• Contribute to the development and implementation of primary and secondary analysis software.
• Improve and run production pipelines for large-scale single-cell perturbation screens to ensure timely and reliable data delivery
• Contribute to the development of reproducible, well-documented computational workflows and internal best practices
• Develop microservice web applications and integrations that reduce wet lab manual effort and improve data flow between teams
Qualifications:
Required:
• Bachelor’s, Master's, or PhD in Bioinformatics, Biostatistics, Computational Biology, Computer Science, or a related technical field
• Experience analyzing and interpreting single-cell or multi-omics datasets (e.g., scRNA-seq, multiome, scATAC-seq), with hands-on exposure to perturbation screens preferred
• Familiarity with core single-cell bioinformatics workflows, including demultiplexing, alignment, and quality control
• Strong software engineering fundamentals and experience working with bioinformatics tools and pipelines
• Working knowledge of statistical and machine learning methods applied to biological data (e.g. regression analysis, supervised learning) sufficient to critically evaluate analytical choices and interpret results conceptually
Preferred:
• Proficiency with Python-based data science tools (NumPy, SciPy, Pandas)
• Experience with cloud computing environments (AWS, GCP, or Azure)
• Strong Python programming skills and comfort working in Unix-based environments
• Experience with containerized workflows (Docker, Singularity)
• Familiarity with molecular biology workflows and experimental genomics
Company:
NewLimit is a biotech company developing epigenetic therapies to extend human healthspan by reprogramming aging cells. Founded in 2022, the company is headquartered in South San Francisco, USA, with a team of 11-50 employees. The company is currently Early Stage.

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