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Computational Modeling Jobs in Chicago, IL (NOW HIRING)

Computational Biologist

Chicago, IL · On-site

$130K - $163K/yr

Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and ... The Opportunity The Biohub Chicago is seeking an exceptional Computational Biologist ...

Your Role As a Computational Designer & Visualization Specialist in our Chicago office, you will ... Your work will span diagrams, parametric models, animations, and real-time content-bridging ...

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Computational Modeling information

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How much do computational modeling jobs pay per hour?

As of Jul 26, 2026, the average hourly pay for computational modeling in Chicago, IL is $56.63, according to ZipRecruiter salary data. Most workers in this role earn between $48.32 and $75.82 per hour, depending on experience, location, and employer.

What jobs in the US pay 300,000 a year?

In computational modeling, senior roles such as lead data scientist, quantitative analyst, or research scientist with extensive experience and advanced skills in programming, machine learning, and statistical analysis can reach or exceed a $300,000 annual salary. These positions often require advanced degrees, strong domain expertise, and may be found in finance, technology, or research institutions. Compensation varies based on industry, location, and level of responsibility.

What is a Computational Modeling job?

A Computational Modeling job involves developing and using mathematical models, simulations, and algorithms to analyze complex systems across various fields, such as engineering, physics, biology, and finance. Professionals in this role apply computational techniques to study real-world phenomena, predict outcomes, and optimize processes. They often work with programming languages, statistical methods, and high-performance computing to create accurate and efficient models.

Is 3D modeling a high paying job?

3D modeling can be a well-paying career, especially for experienced professionals working in industries like gaming, film, or product design. Salaries vary based on skill level, industry, location, and the complexity of projects, with advanced 3D modelers often earning higher wages and working with specialized software such as Blender or Maya.

What is the highest paying job in computational biology?

The highest paying roles in computational biology are often senior positions such as Director of Computational Biology or Principal Scientist, which can earn six-figure salaries. These roles typically require advanced degrees, extensive experience, and expertise in areas like machine learning, bioinformatics tools, and programming languages such as Python or R.

What are the key skills and qualifications needed to thrive in the Computational Modeling position, and why are they important?

To thrive in computational modeling, a strong background in mathematics, computer science, and domain-specific knowledge (such as engineering, physics, or biology) is essential, often supported by at least a bachelor's or master's degree in a related field. Familiarity with programming languages like Python, MATLAB, or R, as well as experience with simulation software and data analysis tools, is typically required. Strong problem-solving, analytical thinking, and effective communication skills set outstanding candidates apart. These abilities enable professionals to build accurate models, collaborate successfully with interdisciplinary teams, and translate complex results into actionable insights.

What does a typical day look like for someone working in computational modeling?

A typical day for a computational modeling professional often involves developing and refining mathematical or computer-based models, running simulations, and analyzing large datasets to draw meaningful conclusions. You’ll collaborate closely with domain experts, engineers, and researchers to ensure models accurately reflect real-world processes. The role may also involve presenting findings to stakeholders, troubleshooting code or software issues, and keeping up with new modeling techniques and industry advancements. This dynamic environment requires balancing independent problem-solving with teamwork and communication.

What is a computational modeler?

A computational modeler is a professional who develops and uses computer-based models to simulate complex systems or processes. They often work with programming languages, mathematical algorithms, and data analysis tools to create accurate representations for research, engineering, or scientific purposes.
What are the most commonly searched types of Computational Modeling jobs in Chicago, IL? The most popular types of Computational Modeling jobs in Chicago, IL are:
What job categories do people searching Computational Modeling jobs in Chicago, IL look for? The top searched job categories for Computational Modeling jobs in Chicago, IL are:
Infographic showing various Computational Modeling job openings in Chicago, IL as of July 2026, with employment types broken down into 74% Full Time, 25% Part Time, and 1% Contract. Highlights an 66% Physical, 2% Hybrid, and 32% Remote job distribution, with an average salary of $117,694 per year, or $56.6 per hour.
Computational Biologist

$60K - $80K/yr

Full-time

Medical, Retirement, PTO

Posted 17 days ago


University Of Chicago rating

8.1

Company rating: 8.1 out of 10

Based on 47 frontline employees who took The Breakroom Quiz

152nd of 611 rated colleges and universities


Job description

Department

BSD MED - Genetic Medicine - Im Research Staff


About the Department

The Section of Genetic Medicine shape the future of personalized medicine with successful research programs focused on the quantitative genetic and genomic science. The Section provides extremely valuable collaborations with investigators in the Department of Medicine who are seeking to develop new and more powerful ways to identify genetic risk factors for common, complex disorders with almost immediate clinical application.
The Section of Genetic Medicine conducts impactful investigations focused on quantitative genetics, systems biology and genomics, bioinformatics and computational biology as well as through extensive collaborations of the faculty throughout the Department of Medicine, Biological Sciences Division and the University of Chicago.


Job Summary

We are seeking a lifelong learner interested in developing statistical and computational tools to sift through large amounts of data to make discoveries that can improve human health. The Computational Biologist will contribute to the development and application of statistical and computational tools across NIH-funded projects, integrating large-scale GWAS with metabolomics data to uncover mechanisms underlying complex diseases and developing polygenic risk scores that transfer genetic signals across human populations and model organisms to study addiction-related traits, COPD, type 2 diabetes, and other common diseases.

Responsibilities

  • Analyze large-scale genomic datasets including RNA-seq, whole genome sequence, and single-cell data.

  • Develop and apply statistical and computational methods to extract biological insights from high-dimensional data.

  • Develop and train deep learning models to improve upon traditional statistical methods in genomics.

  • Collaborate with disease and genomics experts to address pressing biomedical research questions.

  • Write and contribute to scientific publications and present findings at lab and consortium meetings.

  • Help train and mentor students in the lab.

  • Applies research principles and relevant subject matter knowledge relevant to administer a research project. With a moderate level of direction, manages lab and/or research-related duties and tasks. Helps develop, design and conduct research projects according to plan.

  • Takes responsibility for the following laboratory duties: recognizing abnormal results and varying conditions or procedures to correct problems; setting up and performing experiments. Analyze the meaning, significance, causes, and effects of the subject.

  • Performs other related work as needed.


Minimum Qualifications

Education:

Minimum requirements include a college or university degree in related field.


Work Experience:

Minimum requirements include knowledge and skills developed through 2-5 years of work experience in a related job discipline.


Certifications:

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Preferred Qualifications

Education:

  • Master's or doctoral degree in computational biology, bioinformatics, statistics, physics, or other quantitative disciplines with an interest in applying skills to biomedical research.

Experience:

  • Experience with deep learning in genomics and large language models.

  • Experience with large datasets, distributed computing, and databases.

  • Reproducible research tools and workflows (GitHub, Snakemake, Nextflow).

  • Proficiency in R and/or Python.

Preferred Competencies

  • Strong Analytical skills.

  • Problem-solving skills.

  • Organizational skills.

  • Verbal and written communication skills.

  • Ability to work independently and as part of a team

  • Willingness to explore and adopt new ideas and technologies.

  • Analytical, statistical, quantitative, and computational/programming skills.

Application Documents

  • Resume (required)

  • Cover Letter (required)


When applying, the document(s) MUSTbe uploaded via the My Experience page, in the section titled Application Documents of the application.


Job Family

Research


Role Impact

Individual Contributor


Scheduled Weekly Hours

40


Drug Test Required

No


Health Screen Required

No


Motor Vehicle Record Inquiry Required

No


Pay Rate Type

Salary


FLSA Status

Exempt


Pay Range

$60,000.00 - $80,000.00

The included pay rate or range represents the University's good faith estimate of the possible compensation offer for this role at the time of posting.


Benefits Eligible

Yes

The University of Chicago offers a wide range of benefits programs and resources for eligible employees, including health, retirement, and paid time off. Information about the benefit offerings can be found in the Benefits Guidebook.


Posting Statement

The University of Chicago is an equal opportunity employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender, gender identity, or expression, national or ethnic origin, shared ancestry, age, status as an individual with a disability, military or veteran status, genetic information, or other protected classes under the law. For additional information please see the University's Notice of Nondiscrimination.

Job seekers in need of a reasonable accommodation to complete the application process should call 773-702-5800 or submit a request via Applicant Inquiry Form.

All offers of employment are contingent upon a background check that includes a review of conviction history. A conviction does not automatically preclude University employment. Rather, the University considers conviction information on a case-by-case basis and assesses the nature of the offense, the circumstances surrounding it, the proximity in time of the conviction, and its relevance to the position.

The University of Chicago's Annual Security & Fire Safety Report (Report) provides information about University offices and programs that provide safety support, crime and fire statistics, emergency response and communications plans, and other policies and information. The Report can be accessed online at:http://securityreport.uchicago.edu.Paper copies of the Report are available, upon request, from the University of Chicago Police Department, 850 E. 61st Street, Chicago, IL 60637.


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