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Computational Biophysics Jobs (NOW HIRING)

Astera

Scientist - Computational Biophysics

Emeryville, CA · On-site

$100K - $180K/yr

The diffUSE Project is an ambitious initiative designed to advance our understanding of protein dynamics by building the experimental methods, computational models, and global infrastructure needed ...

Saint Louis University

$55K - $74K/yr

Premila's research group ( at Saint Louis University invites applicants for a postdoctoral research associate position in computational biophysics. The successful candidate will lead project(s ...

Astera

General DiffUSE Job Application

Emeryville, CA · On-site

$100K - $300K/yr

We work at the interface of structural biology (crystallography, cryo-EM), modern machine learning, computational biophysics, and open scientific tooling. Our team spans computational biologists, ML ...

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How much do computational biophysics jobs pay per hour?

As of Jul 26, 2026, the average hourly pay for computational biophysics in the United States is $54.93, according to ZipRecruiter salary data. Most workers in this role earn between $46.88 and $73.56 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in the Computational Biophysics position, and why are they important?

To excel in Computational Biophysics, you generally need advanced knowledge in physics, biology, and mathematics, with a graduate degree (often a Ph.D.) in a related field. Expertise in scientific programming languages (such as Python, C++, or MATLAB), experience with molecular modeling software (e.g., GROMACS, NAMD), and familiarity with high-performance computing environments are essential. Strong analytical thinking, attention to detail, and effective collaboration skills distinguish top performers. These competencies enable professionals to develop and interpret complex simulations, solve biological problems, and contribute significantly to interdisciplinary research teams.

What is a Computational Biophysics job?

A Computational Biophysics job involves using theoretical models, simulations, and computational tools to study biological systems at a molecular or biophysical level. Professionals in this field apply physics, mathematics, and computer science to analyze biomolecular structures, dynamics, and interactions. They work in academia, pharmaceutical companies, or biotech industries, contributing to drug discovery, protein modeling, and materials science. Strong skills in programming, statistical analysis, and molecular dynamics simulations are essential.

What jobs pay $500,000 a year in the US?

In the field of computational biophysics, high-paying roles such as senior research scientists, principal investigators, or industry executives can reach or exceed $500,000 annually, especially with extensive experience, advanced degrees, and leadership responsibilities. These positions often require specialized skills in modeling, simulation, and data analysis, and may include bonuses or stock options in industry settings.

What jobs can I do with a biophysics degree?

A biophysics degree prepares individuals for roles such as computational biophysicist, research scientist, or biomedical data analyst. These jobs often involve using modeling, simulation, and data analysis tools to study biological systems, and may require knowledge of programming languages like Python or MATLAB. Opportunities exist in academia, healthcare, pharmaceuticals, and biotech industries.

What biology jobs pay over $100k?

In computational biophysics, roles such as senior research scientist, bioinformatics director, and computational biologist often have salaries exceeding $100,000 annually. These positions typically require advanced degrees, experience with modeling software, and expertise in data analysis, often within research institutions or biotech companies.

What is computational biophysics?

Computational biophysics is a field that applies computational methods and simulations to study biological systems at the molecular and cellular levels. Professionals in this area often use tools like molecular dynamics software and require knowledge of physics, biology, and programming to analyze complex biological data and model biological processes.

What types of projects or problems do Computational Biophysicists typically work on?

Computational Biophysicists are often engaged in projects such as simulating molecular dynamics, investigating protein folding, drug binding, or membrane behavior, and developing models to understand biological systems at the atomic or molecular level. They frequently collaborate with experimental scientists to interpret data and validate computational predictions, making teamwork and communication skills vital. Typical daily tasks may include running large-scale simulations, analyzing data, writing code for custom analysis, and preparing reports or scientific publications. This role offers diverse challenges and opportunities to contribute to advancements in areas like drug discovery, structural biology, and materials science.

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Computational Biophysics jobs near you
Infographic showing various Computational Biophysics job openings in the United States as of July 2026, with employment types broken down into 3% Internship, 1% As Needed, 85% Full Time, 9% Part Time, and 2% Contract. Highlights an 95% Physical, 1% Hybrid, and 4% Remote job distribution, with an average salary of $114,249 per year, or $54.9 per hour.
Technical Development Principal Scientist - Computational Biophysics

Technical Development Principal Scientist - Computational Biophysics

Genentech, Inc.

South San Francisco, CA • On-site

$120K - $224K/yr

Full-time

This job post has expired 2 days ago. Applications are no longer accepted.

Genentech rating

8.8

Company rating: 8.8 out of 10

Based on 22 frontline employees who took The Breakroom Quiz

11th of 86 rated pharmaceutical

Job description

A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Roche!
As part of Pharma Technical Development (PTD) our organization is committed to deliver the Pharma ambitions by bringing game-changing therapies from clinical phase I into the market to serve every patient, every day. Our core business is to develop safe, innovative and effective drugs using cutting edge technologies for manufacturing process (Drug Substance and Drug Product), clinical supply, formulation, device, packaging, and analytical development.
As an integrated partner within the drug development ecosystem, Global Biologics Pharmaceutical Development is dedicated to effectively developing innovative and patient-centered parenteral drug products including Formulation and Process Development, and Drug Delivery Systems.
The Opportunity
Are you passionate about Computational Biophysics of proteins and looking for a meaningful role? We seek a creative, highly motivated scientist with a background in computational biophysics to join the Pharmaceutical Development Department in US-Pharma Technology Development.
The Scientist will focus on evaluating, developing and employing a variety of in silico methods and workflows to support the development of biologics.
Our unique focus on physics-based simulations, specifically Molecular Dynamics, allows us to help develop and deliver better medicines by reducing problem spaces even in the absence of sizable datasets to learn from. Over the past several years, we have had great success establishing a highly scalable Molecular Dynamics platform, complete with dedicated supercomputing infrastructure.
The ideal candidate will be passionate about and capable of developing cutting-edge computational methods and physics-based simulation techniques to broaden our mechanistic understanding of physico-chemical stability of complex molecular formats and protein drug products. For this position, the chosen individual would independently design, execute and analyze in silico experiments and then inform and collaborate with other scientists and engineers to determine paths forward for drug development.
Who You Are
Requirements
  • Ph.D. in Computational Bioengineering, Biophysics, Computational Chemistry, Physics, Computer Science, Mathematics, or equivalent experience.
  • Extensive in silico expertise with at least one widely used molecular modeling and Molecular dynamics simulation package (e.g., AMBER, GROMACS, NAMD, Rosetta).
  • Familiarity with MOE, Schrodinger, docking tools, homology modeling, quantum mechanics, and structural rendering tools.
  • Familiarity with high-performance scientific computing and proficiency in at least one modern programming language (e.g., Python, Bash scripting, C).
  • Demonstrated ability to independently design, execute, and analyze in silico experiments.
  • Effective verbal and written communication skills, with proven experience collaborating in multi-disciplinary teams.
  • Ability to contribute insightful critical analysis beyond one's specific field of expertise within a scientifically diverse organization.
  • Experience in biologics pharmaceutical development is a plus, but not required.

Relocation benefits are available for this job posting.
The expected salary range for this position based on the primary location of South San Francisco, CA is $120,800 - 224,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

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About Genentech

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A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

Industry

Scientific research and development services

Company size

10,000+ Employees

Headquarters location

South San Francisco, CA, US

Year founded

1976

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