ZipRecruiter

Log In

1

Chemical Downstream Process Engineering Director Jobs

KBI BioPharma Inc.

This may include upstream activities such as cell culture and harvest, and/or downstream processes ... Bachelor's in chemical engineering, Biochemical Engineering, or related field 10+ years of ...

previous pagenext page

Showing results 21-40

All JobsChemical Downstream Process Engineering JobsChemical Downstream Process Engineering Director Jobs

Chemical Downstream Process Engineering Director information

See salary details

$45.5K

$101.3K

$162K

How much do chemical downstream process engineering director jobs pay per year?

As of Sep 11, 2026, the average yearly pay for chemical downstream process engineering director in the United States is $101,323.00, according to ZipRecruiter salary data. Most workers in this role earn between $82,500.00 and $114,500.00 per year, depending on experience, location, and employer.

What does a chemical downstream process engineering director do?

A Chemical Downstream Process Engineering Director oversees the design, optimization, and management of processes that refine, separate, and purify chemical products after initial production. They lead engineering teams, ensure regulatory compliance, and implement best practices for safety, efficiency, and product quality. This role also involves strategic planning, budget management, and collaboration with other departments to drive continuous improvement in downstream operations. Their expertise is critical in industries such as petrochemicals, pharmaceuticals, and food processing.

What are the key skills and qualifications needed to thrive as a chemical downstream process engineering director?

To thrive as a Chemical Downstream Process Engineering Director, you need deep expertise in chemical engineering, process optimization, and leadership, typically supported by an advanced engineering degree and extensive industry experience. Familiarity with process simulation software (e.g., Aspen Plus), quality management systems, and relevant safety certifications is crucial. Exceptional problem-solving, project management, and communication skills help drive cross-functional collaboration and innovation. These abilities ensure efficient, safe operations and strategic advancement of downstream processing within the organization.

What are some common challenges faced by a chemical downstream process engineering director when leading cross-functional teams?

As a Chemical Downstream Process Engineering Director, a key challenge is aligning the goals and timelines of diverse teams, including R&D, operations, and quality assurance. Balancing innovation with regulatory compliance and cost efficiency often requires strong communication and negotiation skills. Additionally, adapting to shifting priorities in a fast-paced production environment and ensuring team members are equipped with the latest process knowledge are ongoing responsibilities. Successfully navigating these challenges ensures smooth scale-up from development to commercial production and fosters a collaborative team culture.

What are popular job titles related to Chemical Downstream Process Engineering Director jobs?

For Chemical Downstream Process Engineering Director jobs, the most frequently searched job titles are:

Infographic showing various Chemical Downstream Process Engineering Director job openings in the United States as of September 2026, with employment types broken down into 1% As Needed, 76% Full Time, 19% Part Time, 3% Contract, and 1% Nights. Highlights an 90% Physical, 2% Hybrid, and 8% Remote job distribution, with an average salary of $101,323 per year, or $48.7 per hour.

Associate Director/Director, Downstream Processing

San Diego, CA • On-site

Debut Biotech
1 - 10 employees
Learn more about Debut Biotechexternal

Full-time

Re-posted 7 days ago

Job description

About Debut
Debut is the unconventional innovation lab spearheading the next generation of big business. Only Debut has a scalable, integrated, climate-positive creation model powered by biotechnology that puts human wellbeing at the center of everything we do-setting the new standard for profitable business and a new pace for an ever-changing world. Our hybrid biotechnology approaches unlock latent markets, providing access to sustainably produced, natural ingredients with health benefits that cannot be obtained through other methods. We are committed to traversing the entire process, from ingredient discovery to the scaling of these products, for consumer markets. If you are passionate, enjoy fast-paced innovation and collaborative teams, then Debut is for you.
Associate Director/Director, Downstream Processing
Summary
The Associate Director/Director, Downstream Processing (DSP) will lead the strategy, development, and execution of downstream purification processes for products made through precision fermentation, with a focus on small molecules for use as cosmetic active ingredients. This individual will serve as the organization's subject matter expert in downstream processing, guiding a team of scientists and engineers through process development at bench, pilot, and manufacturing scale. The candidate will also own the technical relationship with external Contract Development Manufacturing Organization (CDMO) and Contract Manufacturing Organization (CMO) partners, from proposal review through tech transfer and commercial scale-up to manufacturing support.
This is a hands-on leadership role that requires deep technical expertise in downstream unit operations, strong cross-functional collaboration skills, and the ability to translate laboratory-scale processes into robust, cost-effective, and scalable manufacturing solutions.
Essential Functions
  • Direct the development of downstream purification processes for fermentation-derived products, from bench scale (grams) through pilot scale (kilograms) to manufacturing scale (tons per year).
  • Provide hands-on technical expertise across downstream unit operations, including centrifugation, filtration (dead-end and tangential flow), distillation, precipitation, adsorption chromatography (HIC, IEX), liquid/liquid extraction, crystallization, and drying.
  • Establish and maintain a flexible, efficient downstream processing laboratory equipped for rapid process development, troubleshooting, and technology transfer.
  • Evaluate and manage CDMO and CMO partnerships, including authoring requests for proposals, reviewing vendor proposals, and conducting site visits and inspections.
  • Serve as the primary technical point of contact for external manufacturing partners during scale-up and manufacturing phases.
  • Author and lead technology transfer packages to CDMO and CMO partners.
  • Serve as project manager for CDMO and CMO scale-up projects, ensuring timelines, budgets, and quality standards are met.
  • Provide experimental, modeling and statistical capabilities to ensure successful process transfer and robustness at scale
  • Identify, specify, and oversee the purchase of scale-relevant downstream processing equipment for external manufacturing partners.
  • Partner with quality, regulatory, and supply chain teams to ensure downstream processes meet all applicable standards.
  • Communicate technical progress, risks, and recommendations to senior leadership.
  • Lead and mentor a team of downstream process development scientists and engineers
  • Set the technical direction and strategic priorities for the Downstream Processing function.
  • Define and track key performance indicators for the team, including yield, purity, scalability, and cost.
  • Collaborate closely with upstream process development and strain engineering leads to align on integrated process development strategies.

Education and Experience
  • PhD + 10 years of experience; OR Master's Degree + 16 years of experience; OR Bachelors Degree + 18 years of experience.
  • Significant experience in downstream process development for fermentation-derived products, with demonstrated expertise across lab, pilot, and manufacturing scales.
  • Demonstrated expertise in downstream unit operations, including centrifugation, filtration, distillation, precipitation, chromatography, liquid/liquid extraction, crystallization, and drying.
  • Experience managing or leading technical teams, including mentoring scientists and engineers.
  • Proven experience authoring and executing technology transfers to CDMO or CMO partners.
  • Experience serving as a technical project manager for external scale-up or manufacturing projects.
  • Strong written and verbal communication skills, with the ability to convey technical information to both technical and non-technical stakeholders.
  • Experience evaluating and selecting CDMO or CMO partners, including RFP authorship and site audits.
  • Familiarity with mass balance review and master batch record oversight.
  • Experience specifying and procuring scale-relevant process equipment.
  • Background in microbial (bacterial and yeast) fermentation DSP processes, of both hydrophobic and hydrophilic target compounds.

Travel Requirements
This role requires travel of approximately 20% to support CDMO and CMO site visits, inspections, technology transfer activities, and on-site collaboration during scale-up and manufacturing phases. Travel may include both domestic and international destinations, depending on the location of manufacturing partners.
Essential Physical Characteristics
The physical characteristics described here are representative of those that must be met by an employee to successfully perform the essential functions of this position. Reasonable accommodations may be made to enable qualified individuals with disabilities to perform the essential functions of a job, on a case-by-case basis.
  • Continuous upward and downward flexion of the neck.
  • Frequent: sitting, repetitive use of hands to operate computers, printers and copiers.
  • Frequently uses hands to feel objects or control tools (e.g. pipetting). Laboratory operations require dexterity and care to perform studies as required.
  • Occasional: walking, standing, climbing stairs, bending and twisting of neck, bending and twisting of waist, squatting, simple grasping, reaching above and below shoulder level, and occasional lifting and carrying of files or material weighing up to 50 pounds.
  • Must be willing to work with biohazardous agents (up to BSL2) and chemicals.
  • The R&D laboratory will result in exposure to hot and cold temperatures, noise, fumes, limited dust, and oily coolants.
  • The performance of this position will present exposure to an industrial environment and requires support and compliance with the published Company PPE policy including but not limited to the use of personal protective equipment such as safety glasses with side shields, appropriate attire, safety shoes, hard hat, hearing protection, etc.

Condition of Employment
As part of Debut's pre-employment process, prospective candidates will undergo a background check prior to beginning employment. Additional types of background investigations may be conducted based on the job-related activities of the position.
Debut is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.
Salary: $150,000-$180,000

Apply