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Cell Therapy Msat Director Jobs (NOW HIRING)

Sana Biotechnology

Director, MSAT

Cambridge, MA · On-site

$200K - $250K/yr

As an MSAT Director, you will report to the Executive Director of MSAT and support manufacturing of ... Experience with key cell therapy equipment and unit operations to support phase 1 clinical trials ...

New

Sana Biotechnology

Director, MSAT

Cambridge, MA · On-site

$200K - $250K/yr

As an MSAT Director, you will report to the Executive Director of MSAT and support manufacturing of ... Experience with key cell therapy equipment and unit operations to support phase 1 clinical trials ...

New

Legend Biotech USA, Inc.

$83K - $104K/yr

Role OverviewLegend Biotech is seeking a detail-oriented and driven Associate Scientist to join our Global MSAT Automation team. This role combines cell therapy manufacturing studies with basic lab ...

Bayer

$22 - $24.50/hr

... Therapy Cell Culture, you are a subject matter expert (SME) responsible for the clinical ... MSAT) for new product introductions and ensure platform alignment; In this role, you act as the ...

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Cell Therapy Msat Director information

What does a Cell Therapy MSAT Director do?

A Cell Therapy MSAT (Manufacturing Science and Technology) Director oversees the transfer, scale-up, and technical support of cell therapy manufacturing processes. They lead teams responsible for ensuring that cell therapy products are produced efficiently, safely, and in compliance with regulatory standards. The role involves collaborating with R&D, quality, and production teams to resolve technical issues, implement process improvements, and support new product launches. Additionally, the MSAT Director ensures that manufacturing processes remain robust and capable of meeting clinical and commercial demands.

What are the main challenges a Cell Therapy MSAT Director faces when scaling up manufacturing processes from clinical to commercial production?

One of the primary challenges for a Cell Therapy MSAT Director is ensuring that the manufacturing processes developed at a clinical scale can be reliably and efficiently scaled up to meet commercial demand without compromising product quality or regulatory compliance. This often requires close collaboration with cross-functional teams, including R&D, Quality Assurance, and Operations, to troubleshoot issues such as process variability and raw material sourcing. Additionally, adapting to evolving regulatory requirements and implementing robust technology transfer protocols are critical for a successful scale-up. Staying ahead of these challenges is crucial for maintaining timelines and ensuring therapy availability for patients.

What are the key skills and qualifications needed to thrive as a Cell Therapy MSAT Director, and why are they important?

To thrive as a Cell Therapy MSAT Director, you need deep expertise in cell therapy process development, manufacturing sciences, and typically a graduate degree in biotechnology or a related field. Familiarity with GMP regulations, quality systems, and platforms like LIMS or MES, along with experience in leading technology transfers, is crucial. Exceptional leadership, problem-solving, and cross-functional communication skills set top candidates apart in this role. These abilities ensure the effective scale-up, compliance, and delivery of advanced cell therapies in a highly regulated, fast-evolving environment.

What are popular job titles related to Cell Therapy Msat Director jobs?

For Cell Therapy Msat Director jobs, the most frequently searched job titles are:

Infographic showing various Cell Therapy Msat Director job openings in the United States as of September 2026, with employment types broken down into 4% As Needed, 67% Full Time, 14% Part Time, and 15% Contract. Highlights an 78% Physical, 1% Hybrid, and 21% Remote job distribution.

Director, MSAT

Cambridge, MA • On-site

Sana Biotechnology
Biotechnology Research and Development • 51 - 200 employees
Learn more about Sana Biotechnologyexternal

$200K - $250K/yr

Full-time

Posted 2 days ago

New

Job description

About the role

Sana Biotechnology is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who are passionate about delivering the possible to patients, and who lead with the desire to work on novel ideas. As an MSAT Director, you will report to the Executive Director of MSAT and support manufacturing of Sana's stem cell-derived pancreatic islet cell program for persons with type 1 diabetes (SC451). You will lead an MSAT team responsible for the PSC seed train and differentiation to beta cells at an external partner. You will define and execute the technology transfer strategy in alignment with program timelines and provide your team with technical mentorship. Your team will provide technical coverage at an external manufacturing partner throughout the phase I manufacturing campaign including people-in-plant, executed batch record review, investigations, and batch summaries. You will collaborate with internal partners across Quality, External Manufacturing, and Supply Chain to complete batch disposition. You will draft applicable CMC sections of regulatory documents (IND module 3). 

What you'll do

  • Lead a team of 2-4 individuals supporting Phase I manufacturing of a PSC-derived pancreatic islet cell therapy product
  • Partner with CDMO technical team to achieve manufacturing readiness and address technical challenges
  • Oversee people-in-plant, manufacturing operator training, technical documentation, and process execution
  • Author CMC sections for regulatory filings (IND module 3) and other technical documents
  • Collaborate with Quality to close deviations, analyze manufacturing trends, and recommend process improvements
  • Lead investigations and troubleshoot process execution challenges including root cause analysis
  • Perform comparability studies in collaboration with Research and PD teams to assess technology transfer success
  • Engage in crucial conversations by providing and receiving feedback supporting the growth and development of team members
  • Demonstrate ability to engage and effectively influence team members across multidisciplinary teams while prioritizing multiple projects and meeting deadlines
  • Drive curiosity, scientific rigor and excellent problem-solving skills across a fast-paced performance driven environment
  • Innate ability to assess talent that will help grow the organization and add to Sana's culture

What we're looking for

  • BSc. in Chemical, Biological, or Biomedical Engineering plus 10 yrs or equivalent combination of education and work experience
  • >5 year experience supporting early phase cell therapy manufacturing including technology transfers
  • Well versed with cGMP requirements and working in a regulated environment, including experience as person-in-plan and/or GMP operator
  • Knowledge of PSC culture and differentiation biology to pancreatic islets
  • Experience managing a team of >3 direct reports
  • Detail-oriented with good problem-solving, technical writing and verbal communication skills
  • Ability to effectively work in multidisciplinary teams, meet deadlines, and prioritize multiple projects
  • Aptitude for working in a self-driven, performance/results-oriented, fast-paced matrix environment

What will separate you from the crowd

  • Experience with key cell therapy equipment and unit operations to support phase 1 clinical trials including cryopreservation
  • Working knowledge of statistical design of experiments (DoE) and RCA
  • Experience working in grade B / ISO 7 cleanroom
  • Understanding of analytical methods such as flow cytometry
  • Experience with cell therapy process closure and automation
  • Knowledge of single-use technologies as applicable to cell therapies
  • Familiar with data analysis tools such as R, Python, JMP and FlowJo software

What you should know

  • Travel to the manufacturing site ~25% of the time (Canada)
  • Some weekend work required
  • Lift up to 25 lbs
  • Work within a cleanroom environment
  • The base pay range for this position at commencement of employment is expected to be between $200,000 and $250,000/year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience

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