The job duties of a registered nurse who works with botox, or a Botox RN, involve administering cosmetic treatments or services to patients. Their responsibilities may include providing information to the patient and helping them choose a course of treatment. The duties of a Botox RN are to administer an injection and communicate with a client to ensure that they do not have adverse reactions. A Botox RN can work in a variety of settings, such as a cosmetic clinic, a dermatology clinic, or providing client services in a spa or beauty facility alongside an esthetician.