1

Biotech Downstream Manager Jobs (NOW HIRING)

$75K - $95K/yr

Manage the development of SOPs to ensure all manufacturing operations comply with internal and ... Bachelor's degree in biology, Biotechnology, Chemical Engineering or related field plus 3 - 5 years ...

Showing results 41-60

Biotech Downstream Manager information

See salary details

$28.5K

$62.7K

$113.5K

How much do biotech downstream manager jobs pay per year?

As of Sep 13, 2026, the average yearly pay for biotech downstream manager in the United States is $62,661.00, according to ZipRecruiter salary data. Most workers in this role earn between $45,000.00 and $69,000.00 per year, depending on experience, location, and employer.

What is a biotech downstream manager?

Biotech Downstream Managers are professionals responsible for overseeing the purification and processing of biological products after the initial production phase (upstream processing) in biotechnology manufacturing. They manage teams, optimize processes, ensure product quality, and maintain compliance with regulatory standards. Their role is crucial in ensuring that biologics such as proteins, antibodies, or vaccines are safely and efficiently purified for use in pharmaceuticals, research, or other applications. They often collaborate with upstream managers, quality assurance teams, and regulatory bodies to achieve production goals. Strong technical knowledge and leadership skills are essential for success in this role.

What are some common challenges a biotech downstream manager faces when scaling up purification processes from lab to production scale?

A Biotech Downstream Manager often encounters challenges such as maintaining product quality and yield when transitioning purification protocols from lab-scale to large-scale manufacturing. Issues can arise with equipment compatibility, process reproducibility, and increased risk of contamination. Strong collaboration with upstream teams, process engineers, and quality assurance is essential to troubleshoot and optimize each stage. Additionally, ensuring compliance with regulatory standards while meeting production timelines requires careful planning and attention to detail.

What are the key skills and qualifications needed to thrive as a biotech downstream manager, and why are they important?

To thrive as a Biotech Downstream Manager, you need expertise in bioprocess engineering, protein purification, and a solid background in biology or chemical engineering, often supported by a relevant degree and experience in biomanufacturing. Familiarity with chromatography systems, filtration technologies, GMP regulations, and process control software is essential. Strong leadership, problem-solving, and communication skills help in managing teams and troubleshooting complex processes. These skills ensure efficient and compliant production of high-quality biopharmaceutical products, directly impacting product success and regulatory approval.

What are popular job titles related to Biotech Downstream Manager jobs?

For Biotech Downstream Manager jobs, the most frequently searched job titles are:

Infographic showing various Biotech Downstream Manager job openings in the United States as of September 2026, with employment types broken down into 86% Full Time, 13% Part Time, and 1% Contract. Highlights an 86% Physical, 2% Hybrid, and 12% Remote job distribution, with an average salary of $62,661 per year, or $30.1 per hour.

Scientist Downstream Processing - Columbia, MD

Columbia, MD โ€ข On-site

DSM
Marketingย โ€ขย 11 - 50 employees

$100K - $135K/yr

Full-time

Medical, Retirement, PTO

Posted 21 days ago


Key responsibilities

  • Design, execute, and analyze downstream processes at bench scale.

  • Drive opportunities to optimize existing processes at production scale, including scale down, scale up, and tech transfer.

  • Work closely with cross-functional teams to resolve complex bioprocess challenges and present data and conclusions to stakeholders.


Job description

Scientist, Downstream Process Development
Location: Columbia, MD
We are seeking a talented and motivated Scientist with expertise in Downstream Processing (DSP), ideally within the field of Biotechnology, to strengthen our research team at the Columbia Biotechnology research hub of dsm-firmenich. In this role, you will lead and contribute to the development of innovative biotechnological processes that enable production of ingredients and products used across a wide range of applications.
The Columbia site serves as the Center of Excellence for Lipids within dsm-firmenich. The successful candidate will bring experience with oil and lipid chemistry, emulsions, and separations technologies. We are looking for a natural communicator, orally and in writing, as well as a team player who can think, act, and discuss scientific concepts and discoveries across disciplines in a constructive and collaborative way. This role offers the opportunity to be innovative with an entrepreneurial way of working. In addition, you will have the opportunity to lead the planning and execution of complex science and research projects including reviews, reporting, and stakeholder management.
Key Responsibilities:
  • Scientific Excellence and Thought Leadership: Apply relevant scientific and engineering knowledge in separations processes to projects and interconnected processes with an eye towards enabling environmentally beneficial and cost competitive biobased solutions to global challenges around nutrition, health, and beauty.
  • Process Development and Optimization: Design, execute, and analyze downstream processes at bench scale. Drive opportunities to optimize existing processes at production scale, with a thorough understanding of scale down, scale up, and tech transfer.
  • Cross-functional collaboration: Work closely with Strain Improvement, Fermentation, Analytical, Manufacturing, and Quality to resolve complex bioprocess challenges. Visualize and present data and conclusions, convincing stakeholders to move solutions from the lab towards implementation.

We Offer:
  • A dynamic R&D environment where you can contribute to impactful innovations.
  • A diversity of exciting projects related to lipids, foods and products used everyday by millions of people.
  • A diverse, international, and interdisciplinary team of industry-leading researchers with a well-equipped research facility.
  • Supportive career development, with opportunities for both vertical and lateral growth.
  • The opportunity to be a part of a company both building upon and shaping a strong legacy through breakthrough industrial innovations and technology.

You Bring:
  • BS in Chemical Engineering, Biotechnology, Bioprocess Engineering, or related field with 5+ years of hands-on experience in industry. MS or PhD in applicable disciplines can be considered partially in lieu of industrial experience.
  • A proven track record on process and product innovation with demonstrated hands-on experience with lab and/or pilot scale bioprocessing recovery equipment.
  • Keen understanding of unit operations, M&E balances, and separation technologies, with experience developing DSP trains and interconnected modeling approaches thereof.
  • Understanding and experience applying statistics and DOE in development of experimental workplans; Six Sigma certification is a plus.
  • A strong sense of ownership, accountability, and motivation with good prioritization and organizational skills.
  • A collaborative spirit - you thrive in cross-functional, international teams and show initiative when contributing to project work.

The salary or hourly wage scale provided reflects the pay range dsm-firmenich expects to pay the successful candidate for the position. Individual pay offered will be based on the applicant's job-related skills, experience, relevant education, or training, and primary work location. This position is also eligible for bonuses and benefits, which are not included in the pay scale provided. Salary $100,000-$135,000.
In addition to base salary, we also offer a comprehensive total rewards package, inclusive of annual incentive pay, a retirement savings plan, health care coverage, paid time off, recognition programs and a broad range of other benefits. All benefits and incentives are subject to eligibility requirements.
About dsm-firmenich
At dsm-firmenich, we don't just meet expectations - we go beyond them.
Join our global team powered by science, creativity, and a shared purpose: to bring progress to life.
From elevating health to making fortified food and sustainable skincare, the impact of your work here will be felt by millions - every single day. Whether it's fragrance that helps you focus, alternative meat that's better for the planet, or reducing sugar without losing flavor, this is where you help shape the future of nutrition, health, and beauty for everyone, everywhere.
And while you're making a difference, we'll make sure you're growing too. With learning that never stops, a culture that lifts you up and the freedom to move across businesses, teams, and borders. Your voice matters here. And your ideas? They're essential to our future.
Because real progress only happens when we go beyond, together.
The application process
Interested in this position? Please apply online by uploading your resume in English.
Inclusion, belonging and equal opportunity statement
At dsm-firmenich, we believe being a force for good starts with the way we treat each other. When people feel supported, included, and free to be themselves, they do their best work - and that's exactly the kind of culture we're building. A place where opportunity is truly equal, authenticity is celebrated, and everyone has the chance to grow, contribute, and feel they belong.
We're proud to be an equal opportunity employer, and we're serious about making our hiring process as fair and inclusive as possible. From inclusive language and diverse interview panels to thoughtful sourcing, we're committed to reflecting the world we serve.
We welcome candidates from all backgrounds - no matter your gender, ethnicity, sexual orientation, or anything else that makes you, you.
And if you have a disability or need any support through the application process, we're here to help - just let us know what you need, and we'll do everything we can to make it work.
Agency statement
We're managing this search directly at dsm-firmenich. If you're applying as an individual, we'd love to hear from you. We're not accepting agency submissions or proposals involving fees or commissions for this role.