ZipRecruiter

Log In

1

Bioreactor Upstream Scientist Jobs (NOW HIRING)

Lonza

R&D Upstream Scientist/Engineer

Bend, OR · On-site

R&D Upstream Scientist/Engineer Bend, OR Today, Lonza is a global leader in life sciences operating ... Completing experiments in a mammalian bioreactor setting * Applying knowledge of biological ...

Lonza

R&D Upstream Scientist/Engineer

Bend, OR · On-site

R&D Upstream Scientist/Engineer Bend, OR Today, Lonza is a global leader in life sciences operating ... Completing experiments in a mammalian bioreactor setting * Applying knowledge of biological ...

Legend Biotech USA, Inc.

Conduct systematic media optimization, feeding strategy evaluation, and bioreactor process control ... Serve as the upstream scientific lead within Vector Biology, providing authoritative technical ...

Lonza

R&D Upstream Scientist/Engineer

Bend, OR · On-site

As a R&D Upstream Scientist/Engineer at Lonza, you will join a dynamic and ambitious team dedicated ... Completing experiments in a mammalian bioreactor setting Applying knowledge of biological, chemical ...

Legend Biotech USA, Inc.

$104K - $132K/yr

Role OverviewThe Senior Scientist, Lentivirus Upstream Process Development, will be a core ... Support the establishment and validation of bioreactor scale-up and scale-down models to ensure ...

next page

Showing results 1-20

All JobsBusiness JobsSales JobsMedical Sales Associate JobsBioreactor Upstream Scientist Jobs

Bioreactor Upstream Scientist information

See salary details

$42.5K

$94.4K

$153K

How much do bioreactor upstream scientist jobs pay per year?

As of Sep 10, 2026, the average yearly pay for bioreactor upstream scientist in the United States is $94,420.00, according to ZipRecruiter salary data. Most workers in this role earn between $59,000.00 and $119,000.00 per year, depending on experience, location, and employer.

What are popular job titles related to Bioreactor Upstream Scientist jobs?

For Bioreactor Upstream Scientist jobs, the most frequently searched job titles are:

Infographic showing various Bioreactor Upstream Scientist job openings in the United States as of August 2026, with employment types broken down into 2% Internship, 1% As Needed, 86% Full Time, 6% Part Time, and 5% Contract. Highlights an 88% Physical, 3% Hybrid, and 9% Remote job distribution, with an average salary of $94,420 per year, or $45.4 per hour.

Scientist II, Upstream Development for Protein Development and Manufacturing

San Carlos, CA

Vaxcyte
Biotechnology Research and Development • 51 - 200 employees
Learn more about Vaxcyteexternal

$146K - $171K/yr

Full-time

Re-posted 12 days ago

Key responsibilities

  • Contribute to the development and characterization of upstream fermentation processes.

  • Serve as a primary technical contributor to bioreactor setup, monitoring, harvest, and maintenance activities.

  • Develop, test, and implement recipe scripting for fed-batch fermentation feeding controls.

Job description

Summary:

Vaxcyte is seeking a talented and experienced Scientist II, to join the Upstream Process Development group within the Protein Development and CMC team. This is an exciting opportunity to join an outstanding team pursuing bacterial fermentation development at Vaxcyte.

The successful candidate will have the following skills and qualities:

  • A skilled upstream scientist with expertise in developing and characterizing bacterial fermentation processes for protein production.
  • Hands-on experience operating and maintaining bioreactors, including Ambr 250, at laboratory scale.
  • Experience with pilot scale fermentation and recovery equipment is a plus.
  • Skillful in analyzing and presenting data for process improvements, troubleshooting, and optimization.
  • An exceptional team player who works seamlessly with others, speaks up, and remains focused on achieving the best results to achieve company goals.
  • An experienced scientist who works with growing independence, collaborates across functional teams, and mentors junior colleagues.
  • Strong organizational and planning skills.
Essential Functions:
  • Contribute significantly to the development and characterization of upstream fermentation processes.
  • Serve as a primary technical contributor to operational activities related to bioreactor set-up, monitoring, harvest, and maintenance.
  • Develop, test, and implement recipe scripting for fed-batch fermentation feeding controls.
  • Provide engineering support for design, implementation, and qualification of scale-down models.
  • Author SOPs (standard operating procedure), process flow diagrams and batch records.
  • Analyze and present fermentation data at internal project meetings. Participate in upstream database management and documentation in electronic notebooks.
  • Collaborate with Downstream Process Development, Pilot Plant, MSAT, or Analytical Development as needed.
  • Provide guidance or mentorship to junior team members.
Requirements: 
  • PhD with 2-5 years, MS with 7 years, or BA/BS with a minimum of 10 years of relevant Pharma/Biotech industry experience. Other combinations of education and/or experience may be considered.
  • Strong scientific background and hands-on experience with fermentation and/or primary recovery unit operations.
  • Good understanding in fundamentals of bioreactor design, operation and controls.
  • Strong knowledge of aseptic techniques
  • Mechanical and technical knowledge of primary recovery unit operations such as homogenization, centrifugation, and depth filtration, is a plus
  • Understanding of fermentation scale up and development of scale down models
  • Familiarity with DoE (Design of Experiments) principles and software.
  • Familiarity with regulatory requirements of biotherapeutics. Late-stage process characterization experience is a plus.
Reports to: Senior Scientist, Upstream Development and Manufacturing
 
Location: San Carlos, CA
 
Work Arrangement (may be adjusted based on business needs, job responsibilities, or changes to company policy): 
Onsite (5 days per week onsite)
 
Compensation:
The compensation package will be competitive and includes comprehensive benefits and an equity component.
 
Salary Range: $146,000 - $171,000
Vaxcyte logo

About Vaxcyte

Sourced by ZipRecruiter

Industry

Biotechnology research and development

Company size

51 - 200 Employees

Headquarters location

San Carlos, CA, US

Year founded

2013

View All Vaxcyte Jobs

Apply