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Bioreactor Process Engineer Jobs (NOW HIRING)

Legend Biotech USA, Inc.

... engineering.Experience with bioreactor operations (up to 50 L preferred) and familiarity with downstream processing operations including clarification, chromatographic purification, and tangential ...

Legend Biotech USA, Inc.

$104K - $132K/yr

... bioreactor scale-up and scale-down models to ensure process comparability and predictability ... Working knowledge in engineering modeling, mass transfer, and bioprocess optimization.Strong ...

PBS Biotech Inc

Service Engineer II

Moorpark, CA · On-site

$74K - $116K/yr

... PBS bioreactor product as well as resolving any technical issues that may occur on the PBS ... Support customer complaint investigations and product feedback processes by gathering field data ...

PBS Biotech

Field Service Engineer II

Camarillo, CA · On-site

$74K - $116K/yr

At PBS Biotech, we develop innovative bioreactor solutions that support customers working at the ... Support customer complaint investigations and product feedback processes by gathering field data ...

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Bioreactor Process Engineer information

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How much do bioreactor process engineer jobs pay per year?

As of Sep 11, 2026, the average yearly pay for bioreactor process engineer in the United States is $92,018.00, according to ZipRecruiter salary data. Most workers in this role earn between $74,500.00 and $103,000.00 per year, depending on experience, location, and employer.

What does a bioreactor process engineer do?

A Bioreactor Process Engineer designs, operates, and optimizes bioreactor systems used for growing cells or microorganisms in industries like pharmaceuticals, biotechnology, and food production. Their responsibilities include selecting appropriate bioreactor technologies, monitoring process parameters, troubleshooting issues, and ensuring product quality and safety. They also work on process scale-up and ensure compliance with regulatory standards. This role often requires collaboration with scientists, production staff, and quality assurance teams.

What are the key skills and qualifications needed to thrive as a bioreactor process engineer?

To thrive as a Bioreactor Process Engineer, you need a strong background in chemical or biochemical engineering, microbiology, and process optimization, typically supported by a relevant engineering degree. Familiarity with bioreactor control systems, process analytical technology (PAT), and regulatory standards such as cGMP is essential, and certifications like Six Sigma or specialized bioprocessing training are advantageous. Problem-solving, attention to detail, and effective collaboration with cross-functional teams are crucial soft skills for excelling in this role. These competencies ensure efficient, safe, and compliant bioprocess operations, directly impacting product quality and manufacturing success.

What are some common challenges faced by bioreactor process engineers during scale-up from laboratory to production batches?

Bioreactor Process Engineers often encounter challenges when scaling up processes, such as maintaining consistent cell growth and product yield, ensuring adequate mixing and oxygen transfer, and controlling parameters like pH and temperature across larger volumes. Equipment limitations and differences in hydrodynamics between small and large reactors can also impact process performance. Effective communication with cross-functional teams, such as quality assurance and operations, is crucial to address these challenges and ensure a successful scale-up.

What is the difference between Bioreactor Process Engineer vs Fermentation Engineer?

AspectBioreactor Process EngineerFermentation Engineer
Required CredentialsBachelor's/Master's in Bioengineering, Chemical Engineering, or related fields; experience with bioreactor systemsBachelor's/Master's in Microbiology, Biotechnology, or related fields; knowledge of fermentation processes
Work EnvironmentBiotech or pharmaceutical manufacturing facilities, R&D labsFood, beverage, or biotech fermentation facilities, labs
Employer & Industry UsageUsed in biotech, pharma, and bioprocessing industriesCommon in food, beverage, and biotech sectors

The main difference is that a Bioreactor Process Engineer focuses on designing, optimizing, and maintaining bioreactor systems for various bioprocesses, while a Fermentation Engineer specializes in fermentation processes, often within food and beverage industries. Both roles require similar technical skills and work environments but differ in their specific applications and industry focus.

What are popular job titles related to Bioreactor Process Engineer jobs?

For Bioreactor Process Engineer jobs, the most frequently searched job titles are:

Infographic showing various Bioreactor Process Engineer job openings in the United States as of September 2026, with employment types broken down into 1% As Needed, 76% Full Time, 19% Part Time, 3% Contract, and 1% Nights. Highlights an 90% Physical, 2% Hybrid, and 8% Remote job distribution, with an average salary of $92,018 per year, or $44.2 per hour.

Upstream Process Development Associate I/II

Durham, NC • On-site

KBI Biopharma, Inc.
Biotechnology Research and Development • 1 - 5K employees
Learn more about KBI Biopharma, Inc.external

$50K - $70K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Re-posted 8 days ago

KBI Biopharma rating

6.3

Company rating: 6.3 out of 10

Based on 7 frontline employees who took The Breakroom Quiz

Job description

Position Summary:
KBI Biopharma seeks to fill a role for Upstream Cell Culture Process Development Associate. This person will lead and assist in cell culture and harvest projects for mammalian cell lines (mainly CHO variants) in support of process development, scale-up, and technology transfer to cGMP manufacturing.
Position Responsibilities:
  • Assist the team in the set-up, operation, and associated analysis of cell culture and bioreactor processes including bioreactor preparation, autoclaving, inoculation, sampling, feeding, data entry, and data analysis for shake flask and various scale bioreactors (ambr15, ambr250, 3 L & 15 L glass bioreactors, 50 L and 200 L Xcellerex single-use bioreactors).
  • Lead in maintaining and monitoring process development experiments in shake flasks and bioreactors. Required to perform calculations for growth rate, specific productivity, and bioreactor agitation and gassing scale up/scale down.
  • Perform data entry and plotting, generate presentations and support writing of technical reports using MS Office (Excel, PowerPoint and Word).
  • Maintain detailed batch sheets and data binders with shake flask and bioreactor test results following good documentation practices (GDP).
  • Assist in data analysis using statistical software like Design Expert (DOE), JMP, etc. and help with writing technical documents and reports.
  • Maintains a cell culture-specific project plan, including raw materials and equipment availability, in preparation of laboratory and pilot- scale runs.
  • Serves as a participant on process development teams and coaches junior individuals on cell culture techniques.
  • If necessary, interacts with client to present data, provide responses to client queries and help take projects from start to finish, either independently or in teams of 2-3 individuals.
  • Assist in process transfer from process development to manufacturing.
  • Experience in medium development will be a plus

Position Requirements:
  • Bachelor's and 1-3+ years' experience, or master's degree and 2+ years' experience in Chemical Engineering, Biotechnology or related area.
  • Working knowledge of mammalian cell culture.
  • Advanced ability with Microsoft Office (Excel, PowerPoint and Word).
  • Demonstrates ability to work both independently and as a member of a team.
  • Excellent customer service skills and the ability to meet strict client deadlines.
  • Flexibility of hours to support cell culture processes over weekends (2-4 weekend days per month) and holidays. Weekend and holiday hours are compensated as a premium in addition to base salary.

Salary: $50,000-$70,000
Salary range provided per current averages and expectations. The salary and job title for this opening will be based on the selected candidate's qualifications and experience and may be outside this range. KBI has a robust total rewards strategy which includes an annual bonus structure for all employees, medical, dental, and vision coverage, paid PTO and holidays, Sabbatical program, 401K matching with 100% vesting in 60 days and employee recognition programs.
KBI Biopharma, Inc. is an EEO/AA employer and actively seeks to diversify its work force. Therefore, all qualified applicants, regardless of race, color, national origin, religion, gender, gender identity, sexual orientation, age, disability or veteran status, are strongly encouraged to apply.
I understand that neither the completion of this application nor any other part of my consideration for employment establishes any obligation for KBI Biopharma, Inc. to hire me. If I am hired, I understand that either KBI Biopharma, Inc. or I can terminate my employment at any time and for any reason, with or without cause and without prior notice. I understand that no representative of KBI Biopharma, Inc. has the authority to make any assurance to the contrary.
I attest with my signature below that I have given to KBI Biopharma, Inc. true and complete information on this application. No requested information has been concealed. I authorize KBI Biopharma, Inc. to contact references provided for employment reference checks. If any information I have provided is untrue, or if I have concealed material information, I understand that this will constitute cause for the denial of employment or immediate dismissal.

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