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Bioinformatics Jobs in Portland, OR (NOW HIRING)

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Bioinformatics information

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$63.3K

$100.5K

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How much do bioinformatics jobs pay per year?

As of Jul 27, 2026, the average yearly pay for bioinformatics in Portland, OR is $100,514.00, according to ZipRecruiter salary data. Most workers in this role earn between $71,800.00 and $137,800.00 per year, depending on experience, location, and employer.

What are typical day-to-day responsibilities for someone working in bioinformatics?

A typical day in bioinformatics often involves analyzing large biological datasets, such as genomic or proteomic sequences, using specialized software and programming languages. You might spend time developing or modifying algorithms, visualizing complex data, and applying statistical methods to interpret research findings. Collaborating closely with biologists, data scientists, and clinicians is common to ensure that computational results are aligned with biological questions. Bioinformatics professionals are also expected to document their work, present findings, and stay updated with new tools and advances in the field, making for a dynamic and engaging work environment.

What is a Bioinformatics job?

A Bioinformatics job involves using computational tools and techniques to analyze biological data, such as genomic sequences, protein structures, and clinical information. Professionals in this field work at the intersection of biology, computer science, and statistics to develop algorithms, databases, and software for processing large-scale biological data. Bioinformaticians are employed in academia, pharmaceutical companies, healthcare, and biotechnology sectors to assist with research, drug discovery, and personalized medicine. Key skills include programming, data analysis, and a strong understanding of molecular biology.

What are the key skills and qualifications needed to thrive in the Bioinformatics position, and why are they important?

To thrive in bioinformatics, you need expertise in biological sciences, strong programming skills (such as Python, R, or Perl), and a solid understanding of statistics, typically supported by a degree in bioinformatics, computational biology, or a related field. Familiarity with bioinformatics databases, software tools (like BLAST, Bioconductor, or Galaxy), and experience with next-generation sequencing data analysis are highly valued. Analytical thinking, problem-solving abilities, and effective communication are essential soft skills for collaborating in interdisciplinary research environments. These skills are crucial for accurately interpreting complex biological data, developing useful computational solutions, and successfully contributing to scientific advancements.

What are the most commonly searched types of Bioinformatics jobs in Portland, OR? The most popular types of Bioinformatics jobs in Portland, OR are:
What are popular job titles related to Bioinformatics jobs in Portland, OR? For Bioinformatics jobs in Portland, OR, the most frequently searched job titles are:
What job categories do people searching Bioinformatics jobs in Portland, OR look for? The top searched job categories for Bioinformatics jobs in Portland, OR are:
What cities near Portland, OR are hiring for Bioinformatics jobs? Cities near Portland, OR with the most Bioinformatics job openings:
Bioinformatics jobs near you
Infographic showing various Bioinformatics job openings in Portland, OR as of July 2026, with employment types broken down into 80% Full Time, and 20% Part Time. Highlights an 60% In-person, and 40% Remote job distribution, with an average salary of $100,514 per year, or $48.3 per hour.

Bioinformatics Scientist - Gene Regulation & Cellular Reprogramming

e184

Portland, OR • On-site

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 2 days ago

Job description

About us

e184 Repro is a biotechnology research company with the mission of advancing in vitro gametogenesis to solve one of biology's most profound challenges: returning the fundamental right to procreate.

We work at the frontier of cutting-edge technology, integrating cellular reprogramming, machine learning-guided optimization, multi-omics analysis, and automated experimental workflows to enable gamete development for individuals facing reproductive challenges.

Role overview

As a Bioinformatics Scientist with a cellular reprogramming background, you will lead computational analysis of multi-modal genomics data (scRNA-seq, ATAC-seq) to identify transcription factor combinations driving desired cell state conversion. This role focuses on gene regulatory network inference, differential analysis of single-cell transcriptomics, and computational prioritization of TF cocktails for cellular reprogramming, requiring deep expertise in multi-platform scRNA-seq analysis and transcriptional regulation biology. You will collaborate closely with wet lab teams to translate computational predictions into experimental designs, while also exploring hybrid approaches that integrate foundation model insights into our reprogramming pipeline.

What youll do

  • Lead end-to-end TF discovery for cellular reprogramming - from multi-platform single-cell genomics analysis (scRNA-seq, ATAC-seq) through GRN inference, differential analysis, and trajectory mapping - to nominate the regulators that flip cell fate.

  • Crack the combinatorial code of reprogramming by ranking TF cocktails as actionable combinations and decoding pooled perturbation and CRISPRa screens at single-cell resolution.

  • Read regulatory grammar straight off the chromatin - accessibility, motifs, synergy, repression - and build the data backbone that harmonizes modalities and platforms into something we can actually model on.

  • Sit shoulder-to-shoulder with wet lab teammates, closing the loop between predictions and screens: ingest fresh NGS readouts, retrain, re-prioritize, and pick the next experiment that teaches the model the most.

Core requirements

  • PhD in Bioinformatics, Computational Biology, or related quantitative field (or MS with 5+ years relevant industry experience);

  • Demonstrated track record applying computational TF ranking and GRN inference to cellular reprogramming problems, transdifferentiation, directed differentiation, or iPSC systems;

  • Multi-platform single-cell RNA-seq expertise: hands-on analysis from at least two different platforms, including platform-specific troubleshooting and quality control;

  • Multi-modal genomics proficiency: ChIP-seq, CUT&RUN, or ATAC-seq analysis including peak calling, differential accessibility, and TF motif enrichment;

  • Hands-on experience with established GRN inference methods to nominate or rank regulators of cell state, beyond literature-curated lists;

  • Experience analyzing pooled perturbation screens (CRISPRa, CRISPR knockout, or barcoded TF overexpression) with single-cell or bulk readouts;

  • Working knowledge of trajectory inference and pseudotime methods for mapping cell state transitions;

  • Strong programming skills in Python and R, with proficiency in Scanpy/Seurat and statistical analysis for high-dimensional data;

  • Comfortable working in a modern computational environment: cloud platforms, workflow managers, containerization, and collaborative version control;

  • Strong publication record and demonstrated cross-functional collaboration with experimental biologists.

Youll stand out with

  • Direct experience nominating or validating TF cocktails that successfully induced a cell state conversion (published or in preparation).

  • Experience with dynamical systems modeling for cell state transitions, or inverse problem approaches for TF combination ranking.

  • Background in advanced trajectory inference (optimal transport, GRN dynamics over pseudotime), Bayesian genomics, multi-omics integration, or cross-species comparative regulatory genomics.

  • Familiarity with transformer architectures in genomics and interest in hybrid classical/ML approaches to gene regulation.

Why e184?

  • Unrivaled impact: Your work directly enables technology that transforms human fertility and reproductive medicine.

  • Full-spectrum growth: Gain exposure to the entire lifecycle of discovery. From screening to mechanistic validation.

  • Best of both worlds: Experience the creative chaos of an early-stage startup with the stability of a well-capitalized company.

  • Elite collaboration: Work alongside a world-class team who are as driven as you are.

What we offer

  • Competitive salary + equity participation is considered

  • State-of-the-art facility in Portland metro area

  • Comprehensive Medical, Dental, Vision, and 401(k) with company match

  • 20 days PTO + 11 paid holidays

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
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