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Bioinformatics Engineer Jobs in Chicago, IL (NOW HIRING)

BiomeSense

Senior Bioinformatics Engineer

Chicago, IL · On-site

$125K - $200K/yr

Senior Bioinformatics Engineer Compensation: $125K - $200K base + 0.25% - 0.5% equity stock options About BiomeSense BiomeSense is a life sciences startup applying gut microbiome (GMB) technologies ...

micro1 AI

Bioinformatics Software Engineer

Naperville, IL · Remote

$80 - $110/hr

Analyze and interpret small-molecule and drug discovery datasets using advanced computational biology, bioinformatics, and cheminformatics methods. * Curate, annotate, and validate chemical and ...

micro1 AI

Bioinformatics Software Engineer

Joliet, IL · Remote

$80 - $110/hr

Analyze and interpret small-molecule and drug discovery datasets using advanced computational biology, bioinformatics, and cheminformatics methods. * Curate, annotate, and validate chemical and ...

micro1 AI

Bioinformatics Software Engineer

Elgin, IL · Remote

$80 - $110/hr

Analyze and interpret small-molecule and drug discovery datasets using advanced computational biology, bioinformatics, and cheminformatics methods. * Curate, annotate, and validate chemical and ...

micro1 AI

Bioinformatics Software Engineer

Chicago, IL · Remote

$80 - $110/hr

Analyze and interpret small-molecule and drug discovery datasets using advanced computational biology, bioinformatics, and cheminformatics methods. * Curate, annotate, and validate chemical and ...

micro1 AI

Bioinformatics Software Engineer

Aurora, IL · Remote

$80 - $110/hr

Analyze and interpret small-molecule and drug discovery datasets using advanced computational biology, bioinformatics, and cheminformatics methods. * Curate, annotate, and validate chemical and ...

Tempus

Bioinformatics Scientist

Chicago, IL · On-site +1

We are seeking a highly motivated and capable Bioinformatics Scientist to join our Liquid Biopsy ... engineers, and product managers to translate cutting-edge research into clinically actionable ...

micro1 AI

Digital Chemistry Specialist - Remote

Elgin, IL · Remote

$90 - $120/hr

Familiarity with software tools, databases, and programming languages commonly used in bioinformatics (e.g., Python, R, RDKit, KNIME). * Strong scientific communication skills, with the ability to ...

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All JobsBioinformatics Engineer JobsBioinformatics Engineer Jobs in Chicago, IL

Bioinformatics Engineer information

See Chicago, IL salary details

$44.3K

$135.1K

$245.9K

How much do bioinformatics engineer jobs pay per year?

As of Aug 17, 2026, the average yearly pay for bioinformatics engineer in Chicago, IL is $135,110.00, according to ZipRecruiter salary data. Most workers in this role earn between $99,000.00 and $161,900.00 per year, depending on experience, location, and employer.

What is a bioinformatics engineer?

A Bioinformatics Engineer is a professional who combines expertise in computer science, statistics, and biology to develop software tools and algorithms for analyzing biological data. They often work with large datasets such as genomic sequences, protein structures, and clinical information to help scientists make sense of complex biological systems. Their work is essential in fields like genomics, personalized medicine, and drug discovery, where managing and interpreting vast amounts of data is crucial. Bioinformatics Engineers may also collaborate with researchers to design experiments and interpret results, bridging the gap between biology and technology.

What are the key skills and qualifications needed to thrive as a bioinformatics engineer?

To thrive as a Bioinformatics Engineer, you need a strong background in biology, computer science, and statistics, often supported by a degree in bioinformatics or a related field. Experience with programming languages such as Python or R, familiarity with databases, and knowledge of tools like BLAST, Bioconductor, or next-generation sequencing (NGS) analysis platforms are typically required. Strong problem-solving, analytical thinking, and effective communication skills help you collaborate with interdisciplinary teams and convey complex findings. These skills and qualifications are essential for efficiently analyzing biological data, developing robust computational tools, and advancing research in genomics and life sciences.

What are some common challenges faced by bioinformatics engineers when integrating new data sources into existing pipelines?

Bioinformatics Engineers often encounter challenges such as data format inconsistencies, varying quality of datasets, and the need to ensure compatibility with existing analysis pipelines. Integrating new data sources may require custom scripts or tools for parsing and preprocessing, as well as thorough validation to maintain reproducibility and reliability of results. Collaboration with wet-lab scientists and software engineers is essential to clarify data requirements and streamline the integration process.

What is the difference between Bioinformatics Engineer vs Bioinformatics Analyst?

AspectBioinformatics EngineerBioinformatics Analyst
Required CredentialsBachelor's or Master's in Bioinformatics, Computer Science, or related fields; programming skillsBachelor's or Master's in Bioinformatics, Biology, or related fields; data analysis skills
Work EnvironmentResearch labs, biotech companies, pharmaceutical firmsResearch institutions, healthcare organizations, biotech companies
Employer & Industry UsageDevelops tools, pipelines, and software for biological data analysisInterprets data, performs statistical analysis, and reports findings

While both roles require a background in bioinformatics and involve working with biological data, Bioinformatics Engineers focus on developing software and tools, whereas Bioinformatics Analysts primarily analyze and interpret data to support research and decision-making.

What does a bioinformatics engineer do?

A bioinformatics engineer develops and applies computational tools and algorithms to analyze biological data, such as genetic sequences and molecular structures. They often work with programming languages like Python or R, utilize databases, and collaborate with biologists to interpret data for research or medical purposes.
More about Bioinformatics Engineer jobs

What are the most commonly searched types of Bioinformatics Engineer jobs in Chicago, IL?

The most popular types of Bioinformatics Engineer jobs in Chicago, IL are:

What are popular job titles related to Bioinformatics Engineer jobs in Chicago, IL?

For Bioinformatics Engineer jobs in Chicago, IL, the most frequently searched job titles are:

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The top searched job categories for Bioinformatics Engineer jobs in Chicago, IL are:

Bioinformatics Engineer jobs near you
Infographic showing various Bioinformatics Engineer job openings in Chicago, IL as of August 2026, with employment types broken down into 91% Full Time, 5% Part Time, and 4% Contract. Highlights an 86% Physical, 6% Hybrid, and 8% Remote job distribution, with an average salary of $135,110 per year, or $65 per hour.

Senior Bioinformatics Engineer

BiomeSense

Chicago, IL • On-site

$125K - $200K/yr

Full-time

Re-posted 27 days ago

Job description

Senior Bioinformatics Engineer
Compensation: $125K – $200K base +  0.25% - 0.5% equity stock options
About BiomeSense
BiomeSense is a life sciences startup applying gut microbiome (GMB) technologies (GutLab, MetaBiome) to advance personalized medicine. We partner with UCSF, UCSD, NIH & the University of Chicago & are backed by LabCorp Ventures, Bluestein Ventures, Seerave Foundation & Emil Capital Partners.
Position
Help build our MetaBiome platform, a software solution for collecting, curating & analyzing longitudinal GMB & health data at scale. Own the infra, pipelines & analytical workflows that turn raw sequencing data into intelligence, with room to grow into a platform leader.
Responsibilities:
  • Bioinformatics Architecture & Infrastructure - design, implement & maintain auditable backend for GMB data from raw shotgun metagenomic sequencing
  • Data Engineering – build & maintain cloud infra: databases, distributed computing workflows & REST endpoints for microbial sequence & clinical metadata
  • Statistical Analysis – Lead design, execution & documentation of reproducible computational experiments end-to-end
  • Methods Development – Develop & implement novel analytical methodologies & algorithms informed by experimental findings & validated via rigorous evaluation
  • Frontend / Backend Development – Design & implement robust data ingestion interfaces leveraging APIs & clinical ontologies, following best practices

Qualifications
Required
  • B.S. /M.S. /PhD in Computational Biology, Bioinformatics or a related field with 3+ yrs industry experience (biotech start-up ideal)
  • Proficiency in Python & JavaScript & experience in production-quality software
  • PostgreSQL or other relational SQL database proficiency
  • Familiarity with clinical ontologies (SNOMED, ICD-11, ATC, LOINC)
  • Familiarity with AWS & best practices in computer security
  • Proficiency with modern frontend web technologies
  • Excellent communication; translates complex scientific concepts to diverse stakeholders
  • Strong ownership mindset & the ability to execute in fast-moving environments
  • Expertise in bioinformatics pipelines, QC & reproducibility

Preferred
  • NGS data experience
  • Familiarity with longitudinal / repeated-measures biological datasets & GMB-specific challenges (compositional data, variability, confounders)
  • Experience integrating ontologies / standardized vocabularies
  • Exposure to cloud infrastructure, workflow orchestration or containerization
  • Interest in AI/ML for large biological datasets

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