Bioinformatics Data Engineer Jobs in Colorado (NOW HIRING)

Job Summary:
Eli Lilly and Company is a global healthcare leader headquartered in Indianapolis, Indiana, dedicated to making life better for people around the world. They are seeking Data Architects to design and build the data infrastructure that enables AI-native drug discovery, focusing on creating schemas, ontologies, data models, and platform architectures that transform scientific data into actionable insights.
Responsibilities:
• Design and implement data models, schemas, and ontologies for chemical, biological, and automation-generated data that serve discovery workflows across the portfolio.
• Define and maintain controlled vocabularies, metadata standards, and FAIR-compliant data frameworks in partnership with Preparedness4Insight.
• Implement semantic data standards (RDF, OWL, SPARQL) and ontology engineering practices to create interoperable, machine-readable scientific data.
• Design and implement data lakehouse architecture using modern platforms (Databricks, Snowflake, or equivalent), including data storage patterns, partitioning strategies, and query optimization.
• Build and optimize ETL/ELT pipelines using Spark, dbt, or similar tools to transform raw scientific data into analytical and ML-ready formats.
• Implement real-time and streaming data integration (Kafka, Kinesis, event-driven patterns) connecting LIMS, instruments, and lab automation systems to the data infrastructure.
• Design and implement knowledge graphs (Neo4j, Amazon Neptune, TigerGraph) that capture molecular, target, pathway, and experimental relationships across the discovery landscape.
• Architect specialized data solutions: array databases (TileDB) for genomics/imaging, document stores (MongoDB) for experimental records, and vector databases for embedding-based retrieval supporting ML and RAG workflows.
• Build query and traversal patterns that enable scientists and AI agents to ask relational questions across the entire data landscape.
• Partner with scientific software engineers to ensure data architectures are implementable, performant, and well-documented.
• Collaborate with Methods4Insight to design data structures that support analytical model training, deployment, and evaluation.
• Work with Tech@Lilly to define scaling strategies, ensure enterprise compliance, and transition data architectures to production-grade management.
• Contribute to build-versus-buy-versus-adopt decisions by evaluating commercial and open-source data platforms against Data Foundry requirements.
Qualifications:
Required:
• B.S. or M.S. in Computer Science, Data Science, Bioinformatics, Computational Biology, Information Science, or related STEM field; Ph.D. valued for ontology and knowledge graph roles.
• B.S. with 7+ years and M.S. with 5+ years of data architecture, data engineering, or scientific informatics' experience.
• SQL skills and experience in multiple database paradigms (relational, graph, document, columnar, key-value).
• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.
Preferred:
• Expertise in at least one of: data modeling/ontologies, data platform engineering (Databricks, Snowflake, Spark), or graph/specialized databases (Neo4j, Neptune, MongoDB).
• Familiarity with cloud platforms (AWS, Azure, or GCP) and modern data integration patterns.
• Understanding of scientific data types and experimental workflows in life sciences or pharma (chemical, biological, HTE data).
• Strong communication skills with ability to translate data architecture concepts for both technical and scientific audiences.
• Pharmaceutical or biotech research industry experience, particularly in discovery data management or research informatics.
• Experience with semantic web technologies: RDF, OWL, SPARQL, Protégé, or equivalent ontology engineering tools.
• Hands-on experience with graph databases (Neo4j, Neptune, TigerGraph) and knowledge graph design patterns for scientific data.
• Data lakehouse architecture experience: Databricks (Delta Lake, Unity Catalog), Snowflake, or equivalent; ETL/ELT with Spark, dbt.
• Experience with streaming/real-time data platforms (Kafka, Kinesis, Flink) and event-driven architectures.
• Familiarity with LIMS, ELN systems (e.g., Benchling), and laboratory instrument data integration.
• Experience with vector databases (Pinecone, Weaviate, pgvector) and embedding-based retrieval for ML/RAG applications.
• Array database experience (TileDB, Zarr) for genomics, imaging, or high-dimensional scientific data.
• Experience with bioinformatics data formats (FASTA, BAM/CRAM, VCF) and biological sequence databases; familiarity with NGS data pipelines and proteomics data management.
• FAIR data principles implementation experience and Data Readiness Level frameworks.
• Scientific data standards and controlled vocabularies in chemistry (InChI, SMILES) or biology (Gene Ontology, UniProt, pathway databases such as Reactome or KEGG).
Company:
We're a medicine company turning science into healing to make life better for people around the world. Founded in 1876, the company is headquartered in Indianapolis, USA, with a team of 10001+ employees. The company is currently Late Stage.